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Binuclear zinc complex and preparation method and applications thereof

A zinc complex and coordination technology, applied in zinc organic compounds, drug combinations, antitumor drugs, etc., can solve the problem that the number of bases specifically recognized by natural nucleases cannot meet the rapid growth, and achieve good bonding and The effect of cutting effect, good anticancer activity, and simple preparation method

Inactive Publication Date: 2013-07-24
NANKAI UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, the variety, quantity, price and number of bases specifically recognized by natural nucleases are far from meeting the needs of rapid growth

Method used

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  • Binuclear zinc complex and preparation method and applications thereof
  • Binuclear zinc complex and preparation method and applications thereof
  • Binuclear zinc complex and preparation method and applications thereof

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Embodiment Construction

[0021] The present invention is described in detail as follows with reference to embodiment:

[0022] Synthesis of the main ligand L xHClO4:

[0023] Dissolve 5.83g (35.5mmol) of 2-chloromethylpyridine hydrochloride in 7mL of distilled water and keep stirring, slowly add 1.48g (7.46mmol) of 4,4'-diaminodiphenylmethane in 15mL of ethanol solution, wait After the two were mixed evenly, 2.37g (59.3mmol) NaOH 7mL aqueous solution was slowly dropped into the system, reacted at room temperature and protected from light for two weeks, stopped stirring, the solution was layered, and the lower layer was a black-red oily substance. The above reaction solution was extracted with 3x20mL dichloromethane, the organic layer solution was collected, dried with anhydrous MgSO4 for 1 hour, and the solvent was removed by rotary evaporation to obtain a red oil, which was dissolved in 80mL of absolute ethanol, and then slowly added dropwise to concentrated Perchloric acid produces yellow-brown L·x...

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Abstract

The invention relates to a binuclear zinc complex and a preparation method and applications thereof. The chemical formula of the binuclear zinc complex is [Zn2L(OAc)2(CH3OH)4](ClO4)2, wherein L is 4,4'-bis(N,N-bis(pyridine-2-methyl)) diaminodiphenyl methane, and OAC is acetate radical. The compound crystal belongs to a monoclinic system, the space group is C2 / c, and the crystal cell parameter beta is 117.93(3) degrees. The target compound is prepared by reaction between the ligand L.xHClO4 and zinc acetate. A plurality of spectrographic methods represent and discover that the compound has stronger bonding effect on the CT-DNA; agarose electrophoresis experiment verifies that the compound has obvious cutting effect on Pbr322 DNA; and the MTT experiment verifies that the compound has better anti-cancer activity to HeLa cells, so that the binuclear zinc complex can be used as potential anti-cancer drugs. The preparation method is simple and reliable.

Description

technical field [0001] The invention relates to a binuclear zinc complex, a preparation method and its application, in particular to the application of the binuclear zinc complex in the fields of chemical nucleases and anticancer drugs. Background technique [0002] In recent years, the incidence of cancer has been on the rise, and the treatment of cancer is particularly urgent. Therefore, the development of new and effective anticancer drugs is a very urgent and important topic in the world today. In the late 1960s, the discovery and clinical application of cisplatin’s anti-tumor effect opened up a new field of metal complex anti-tumor drug research. Metal complexes with toxicity and antitumor activity are constantly being synthesized. [0003] Carcinogenesis is the mutation of normal cells to cancer cells, and from a chemical point of view, it is the canceration of nuclear DNA; therefore, the technology of DNA positioning break and recombination is the core technology of ...

Claims

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Application Information

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IPC IPC(8): C07F3/06A61P35/00
Inventor 高春艳田金磊汪碧微阎世平
Owner NANKAI UNIV
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