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Method for preparing 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule and prepared microcapsule

A slow-release, microcapsule technology, applied in the field of pesticides, can solve the problems of difficult transportation, easy stratification, single dosage form of thiophanate copper, and achieve the effect of reducing tedious work and stable storage.

Active Publication Date: 2013-07-31
TOBACCO RES INST CHIN AGRI SCI ACAD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing dosage form of thiazolyl copper is relatively simple, which is 20% suspension concentrate
The disadvantages of this dosage form are: the application method is single, mostly spraying treatment, poor controllability, and is greatly affected by the natural environment. If it is washed by rain after the application, the efficacy of the drug will be affected; the effect of the drug is limited to a short period of time after application. Due to the growth and metabolism of plants, the drug cannot act on the target for a long time; the preparation is easy to stratify during storage, which affects the dispersibility of the active ingredients of the drug in the liquid; it is not easy to transport and other shortcomings

Method used

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  • Method for preparing 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule and prepared microcapsule

Examples

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preparation example Construction

[0038] The present invention also provides a preparation method of the above-mentioned thiazolyl copper sustained-release microcapsules, which comprises the following steps:

[0039] The first step is the preparation of the prepolymer, dissolving the isocyanate derivatives in cyclohexanone, adding a chain extender, heating and reacting to obtain the prepolymer;

[0040] In the second step, the preparation of the emulsion, the prepolymer prepared in the first step is dissolved in water, and stirred until the prepolymer is completely dissolved to form a mixed solution, and the mixed solution of the capsule core is added and emulsified to prepare an emulsion. The mixed solution of the capsule core is It is obtained by stirring and mixing thiabyl copper, capsule core solvent and co-solvent;

[0041] The third step is to polymerize the capsule wall, mix the urea-formaldehyde resin prepared by polycondensation of urea and formaldehyde solution with the emulsion prepared in the secon...

Embodiment 1

[0056] In a 500mL container, dissolve 20g of hexamethyl diisocyanate in 60g of cyclohexanone, place the container in an oil bath, and stir magnetically at a speed of 400r / min. 18 g of 1,4-butanediol was added to the reaction vessel, and the reaction was continued for 20 hours. Afterwards, the reaction mixture was distilled at 100° C. for 6 hours to distill off excess cyclohexanone, water, and hexamethyl diisocyanate, leaving a light yellow, viscous prepolymer.

[0057] Take another 500mL container, dissolve 40g of prepolymer in 250mL of water, stir magnetically until the prepolymer is completely dissolved, add 5g of Thiobacterium copper, 20g of methyl soyate and 4g of geminipyrrolidone, and mix evenly, and emulsify at high speed The machine emulsifies at a speed of 10000r / min for 20 minutes to form an O / W emulsion.

[0058] Add 20g of urea and 25g of formaldehyde solution with a mass percent concentration of 37% to the emulsion to form a mixed solution. The temperature is slo...

Embodiment 2

[0060] In a 500ml container, dissolve 30 g of hexamethyl diisocyanate in 50 g of cyclohexanone, place the container in an oil bath, and stir magnetically at a speed of 1200 r / min. After reacting for 0.5 hours, 5 g of ethylene glycol was added to the reaction vessel at a rate of 5 mg / s, and the reaction continued for 40 hours. Afterwards, the reaction mixture was distilled at 100° C. for 5 hours to distill off excess cyclohexanone, water, and hexamethyl diisocyanate, leaving a light yellow, viscous prepolymer.

[0061] Take another 500ml container, dissolve 60g of prepolymer in 250mL of water, stir until the prepolymer is completely dissolved, add 10g of capsule core mixed liquid Thiobacterium copper, 20g of coco fatty acid methyl ester and 1g of lauryl alcohol ester into the capsule core The mixture is mixed evenly, emulsified by a high-speed emulsifier at a speed of 30000r / min for 10 minutes to form an O / W emulsion.

[0062] Add 30g of urea and 35g of formaldehyde solution w...

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Abstract

The invention provides a 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule which comprises a capsule core and a capsule wall. The capsule core comprises 2-amino-5-thiol-1, 3, 4-thiadiazole copper, capsule core solvent and co-solvent. Components of the capsule wall comprise urea, formaldehyde solution and performed polymers. The 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule is prepared in an emulsion polymerization mode. The 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule has the advantages that in the process of application, inert ingredients, such as a wetting agent, do not need to be added, long-time action on a target object can be achieved; the problem that after the microcapsule application, due to ultraviolet light, illumination and raining, decomposition is affected is solved; after the application of the 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule, the capsule core automatically releases the agents as time goes by, and tedious work, such as manual mist spray, in the process of production is reduced; under the environment of normal temperature and normal pressure, the microcapsule is stable in storage.

Description

technical field [0001] The invention relates to the technical field of pesticides, in particular to a slow-release microcapsule of thimethinate copper used as a plant protection fungicide. Background technique [0002] With the enhancement of human awareness of environmental protection, functional, labor-saving, safe and low-consumption formulations have become the development direction of pesticide formulations at home and abroad. Microcapsules are a kind of controlled-release preparations, which wrap pesticides with polymer membranes and process them into tiny spheres with a diameter of several microns to hundreds of microns. The main features of this type of agent are: 1. It exerts the drug effect at the point of action for a long time and has a long duration; 2. The dosage is small, which reduces the toxicity and irritation to humans and animals, reduces the toxicity to fish, and reduces the drug damage; 3. Reduces Decomposition, loss and volatilization of pharmaceutica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/28A01N43/824A01P1/00A01P3/00
Inventor 冯超孔凡玉王凤龙张成省王静徐茜张玉芹陈志厚林勇
Owner TOBACCO RES INST CHIN AGRI SCI ACAD
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