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Porous nano-ceramic constructed by hydroxyapatite nanorods or sheets and preparation method thereof

A technology of hydroxyapatite and nano-ceramics, which is applied in the fields of porous nano-ceramics, preparation of porous nano-ceramics, bioceramics and its preparation, and can solve the problem that calcium phosphate porous bioceramics cannot be produced on a large scale, limit the use of porous bioceramics, increase the The risk of large ceramic implantation and other issues can be improved to achieve the effect of improving in vivo degradability, improving biological performance, and avoiding mechanical strength

Inactive Publication Date: 2013-08-07
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the mechanical properties of calcium phosphate porous bioceramics prepared by microwave sintering are much lower than those of traditional calcium phosphate bioceramics, which increases the risk of implantation of the ceramics. In addition, another huge defect of this method is the use of Calcium phosphate porous bioceramics prepared by microwave sintering cannot be produced on a large scale
This also limits the use of such porous bioceramics

Method used

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  • Porous nano-ceramic constructed by hydroxyapatite nanorods or sheets and preparation method thereof
  • Porous nano-ceramic constructed by hydroxyapatite nanorods or sheets and preparation method thereof
  • Porous nano-ceramic constructed by hydroxyapatite nanorods or sheets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The traditional porous ceramics containing tricalcium phosphate used in this example are as figure 1 As shown in the SEM photos, the composition ratio of tricalcium phosphate in its chemical composition containing tricalcium phosphate accounts for 40%.

[0037] A concentration of 0.2 mol / L ethylenediaminetetraacetic acid aqueous solution was mixed with a concentration of 0.2 mol / L of Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4Mix the aqueous solution to obtain a mixed aqueous solution, use hydrochloric acid and sodium hydroxide to control the pH value of the mixed aqueous solution to 8, and then add tricalcium phosphate containing 40% tricalcium phosphate and hydroxyapatite dual-phase porous ceramics together with the obtained mixed aqueous solution In the hydrothermal reaction kettle, the hydrothermal reaction is carried out at a temperature of 150° C., and the reaction time is 24 hours, and the porous nano-biological ceramics constructed of hydroxyapatite nanorods are...

Embodiment 2

[0039] The traditional porous ceramics containing tricalcium phosphate used in this embodiment has a chemical composition of 100% tricalcium phosphate.

[0040] A concentration of 0.5 mol / L ethylenediaminetetraacetic acid aqueous solution was mixed with a concentration of 0.5 mol / L of Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The aqueous solution is mixed to obtain a mixed aqueous solution, and the pH value of the mixed aqueous solution is regulated by hydrochloric acid and sodium hydroxide, and then the porous ceramics containing 100% tricalcium phosphate and the obtained mixed aqueous solution are added together in a hydrothermal reaction kettle, and the temperature is The hydrothermal reaction is carried out at 120° C. for 48 hours to obtain porous nano-biological ceramics constructed of hydroxyapatite nanorods. Wherein, the diameter of the hydroxyapatite nanorod is 600 nanometers, and the length is 1200 nanometers. Such as figure 2 Shown is the SEM image of the porous...

Embodiment 3

[0042] The traditional porous ceramics containing tricalcium phosphate used in this embodiment, wherein the composition ratio of tricalcium phosphate accounts for 60%.

[0043] A concentration of 0.3 mol / liter ethylenediaminetetraacetic acid aqueous solution was mixed with a concentration of 0.4 mol / liter of Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The aqueous solution is mixed to obtain a mixed aqueous solution, and the pH value of the mixed aqueous solution is controlled by hydrochloric acid and sodium hydroxide to 12, and then tricalcium phosphate containing 60% tricalcium phosphate and hydroxyl-deficient apatite dual-phase porous ceramics and the resulting mixed aqueous solution Put them together into a hydrothermal reaction kettle, carry out a hydrothermal reaction at a temperature of 180° C., and have a reaction time of 4 hours to obtain a porous nano-biological ceramic constructed of hydroxyapatite nanorods. Wherein, the diameter of the hydroxyapatite nanorod is 50 n...

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Abstract

The invention relates to porous nano-ceramic constructed by hydroxyapatite nanorods or sheets and a preparation method thereof, belonging to the technical field of biological materials. The method comprises the following steps: performing nanocrystallization on porous ceramic containing tricalcium phosphate by using a hydrothermal method, namely mixing an ethylenediaminetetraacetic acid water solution with the concentration of 0-0.5mol / L and a water solution of Ca(NO3)2.4H2O and (NH4)2HPO4 with the concentration of 0-0.5mol / L and the molar ratio of Ca: P of 1.67 to get a mixed water solution; regulating the pH value by using hydrochloric acid and sodium hydroxide; and further adding the porous ceramic containing tricalcium phosphate and the mixed water solution into a hydrothermal reaction kettle for reaction, and controlling temperature and time to get the porous nano-ceramic constituted by the hydroxyapatite nanorods or nano-sheets. Compared with traditional calcium phosphate porous ceramic, the porous nano-ceramic constructed according to the invention has the advantages of higher biological activity and improved degradability; and the preparation method is simple, high in repeatability and capable of realizing large-scale production.

Description

technical field [0001] The invention relates to a bioceramic and its preparation technology, in particular to a porous nanoceramic constructed of hydroxyapatite nanorods or hydroxyapatite nanosheets, and a method for preparing the porous nanoceramic, belonging to biomaterial technology field. Background technique [0002] The preparation of calcium phosphate into bioceramics with porous structure has been widely used clinically as a filling material for repairing hard tissue defects. The reason why calcium phosphate porous bioceramics can be applied to hard tissue repair is that they have similar inorganic chemical composition to bone, and these calcium phosphate porous bioceramics have been proved to have good biocompatibility and osteoconductivity. However, due to the constraints of the preparation method, most of the current traditional calcium phosphate porous bioceramics are constructed from calcium phosphate particles with a diameter greater than 1 micron. The calciu...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622C04B38/00B82Y40/00
Inventor 洪友良陈莹
Owner SICHUAN UNIV
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