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Method for preparing medicine-carrying wound dressing based on supercritical fluid technology

A supercritical fluid and wound dressing technology, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of excessive organic solvent content, denaturation and inactivation of protein drugs, and large amount of organic solvents, so as to achieve low solvent residue and drug The effect of less loss and mild operating conditions

Inactive Publication Date: 2013-08-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is simple to operate, there are some shortcomings and deficiencies, such as a large amount of organic solvent, excessive residual organic solvent content in the product, and the need for subsequent product purification processes, etc., which can easily cause denaturation and inactivation of protein drugs.
With the improvement of living standards, people's requirements for clinical efficacy and safety are getting higher and higher, and this method is obviously difficult to meet the needs of society.

Method used

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  • Method for preparing medicine-carrying wound dressing based on supercritical fluid technology
  • Method for preparing medicine-carrying wound dressing based on supercritical fluid technology
  • Method for preparing medicine-carrying wound dressing based on supercritical fluid technology

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preparation example Construction

[0017] The preparation method of drug-loaded wound dressing based on supercritical fluid technology comprises the following steps:

[0018] 1) Dissolve chitosan in acetic acid aqueous solution to form a chitosan solution with a mass volume ratio of 1 to 5%, and mix the chitosan solution with a cellulose sodium sulfate aqueous solution with a mass volume ratio of 1 to 5% to form chitosan A polyelectrolyte solution with a mass ratio of 1:2 to 2:1 to cellulose sodium sulfate, take the polyelectrolyte solution, stir for 1 to 5 minutes, and freeze-dry to obtain a composite material wound dressing;

[0019] 2) Wrap the composite wound dressing in filter paper and place it in the autoclave of the supercritical fluid drug loading system. The drug is pre-filled in the autoclave, and the drug is not in direct contact with the composite wound dressing;

[0020] 3) Introduce carbon dioxide into the autoclave, and the carbon dioxide reaches a supercritical state under the conditions of a t...

Embodiment 1

[0023] Example 1: Preparation of chitosan / cellulose sodium sulfate composite wound dressing loaded with ibuprofen

[0024] First, chitosan (122mpa.s, deacetylation degree 90%) is dissolved in acetic acid aqueous solution to form a chitosan solution with a mass volume ratio of 1%, and the chitosan solution is mixed with cellulose sodium sulfate with a mass volume ratio of 1%. (substitution degree 0.2) aqueous solution is mixed to form a polyelectrolyte solution with a mass ratio of chitosan and cellulose sodium sulfate of 1:1, and the polyelectrolyte solution is stirred with a stirrer for 1 min, and the obtained polyelectrolyte solution is freeze-dried to obtain chitosan / Cellulose Sodium Sulfate Composite Wound Dressing. The prepared composite wound dressing was wrapped in filter paper and placed in an autoclave. 2 g of ibuprofen was placed in the autoclave in advance, and the ibuprofen did not directly contact with the composite wound dressing. Use the cooling tank to coo...

Embodiment 2

[0029] Example 2: Preparation of chitosan / cellulose sodium sulfate composite wound dressing loaded with ibuprofen

[0030] First, chitosan (186mpa.s, deacetylation degree 95%) is dissolved in acetic acid aqueous solution to form a chitosan solution with a mass volume ratio of 3%, and the chitosan solution is mixed with cellulose sodium sulfate with a mass volume ratio of 5%. (substitution degree 0.2) aqueous solution was mixed to form a polyelectrolyte solution with a mass ratio of chitosan and cellulose sodium sulfate of 1:2, and the polyelectrolyte solution was stirred with a stirrer for 5 minutes, and the obtained polyelectrolyte solution was freeze-dried to obtain chitosan / Cellulose sodium sulfate composite wound dressing. The prepared composite wound dressing was wrapped in filter paper and placed in an autoclave. 2 g of ibuprofen was placed in the autoclave in advance, and the ibuprofen did not directly contact with the composite wound dressing. Use the cooling tank ...

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Abstract

The invention discloses a method for preparing a medicine-carrying wound dressing based on a supercritical fluid technology. The method comprises the steps of mixing and stirring a chitosan acetic acid water solution with a cellulose sodium sulfate solution, freezing and drying to form a composite wound dressing; coating the composite wound dressing into a filter paper to be put into a high-voltage kettle of a supercritical fluid medicine-carrying system; putting the medicine into the high-voltage kettle in advance, preventing the medicine from directly contacting the composite wound dressing, leading supercritical carbon dioxide to fully act on the composite wound dressing; dipping the medicine into the composite wound dressing; and forming the medicine-carrying wound dressing after decompressing because of dissolving of the supercritical carbon dioxide on the medicine. The method has the advantages of mild operation condition, simple operation process, stable process and no organic solvent residue, and can be applied to treatment of burns and scalds and deep wounds.

Description

technical field [0001] The invention relates to a method for preparing a drug-loaded wound dressing based on supercritical fluid technology. Background technique [0002] In the clinical treatment of wounds such as acute trauma and burns, it is very necessary to select a suitable wound dressing in time to treat the wound surface. Traditional wound dressings, such as cotton gauze, have no effect on promoting wound healing, have limited ability to manage exudate, and tend to adhere to new tissue, causing secondary trauma. In recent years, biocompatible polymers have become more and more widely used in clinical medicine. Using biocompatible polymers as a matrix and loading bacteriostatic drugs as wound dressings has many benefits. For example, drug-loaded wound dressings have bacteriostatic properties. , can prevent bacterial infection; the polymer has certain hygroscopicity, which can remove the exudate from the wound surface in time; it has controllable water vapor permeatio...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 关怡新唐川杜哲沈煜斌姚善泾朱自强
Owner ZHEJIANG UNIV
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