Naphthoyl amine derivative, and preparation method and application thereof

A technology for naphthylcarboxamide and derivatives, applied in the field of naphthylcarboxamide derivatives, can solve the problems of low yield, unsuitable industrial production, high price, etc., achieve high yield, simple and easy control of the reaction process, and reduce reaction cost Effect
CN103288728AInactive Publication Date: 2013-09-11HUAQIAO UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAQIAO UNIVERSITY
Publication Date
2013-09-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a naphthoyl amine derivative, and a preparation method and an application of the same. The naphthoyl amine derivative is N-(3- trifluoromethyl phenyl)-6-[(7- chloroquinoline-4-oxo) phenolic ether]-2- naphthoyl amine; the N-(3- trifluoromethyl phenyl)-6-[(7- chloroquinoline-4-oxo) phenolic ether]-2- naphthoyl amine can be used as protein kinase inhibitor and histone deacetylase inhibitor, and can be used for treating diseases caused by protein kinase dysregulation. The naphthoyl amine derivative can effectively treat the diseases caused by protein kinase dysregulation, and has the advantages of high bioavailability, obvious antitumor activity and low toxicity; moreover, the naphthoyl amine derivative is low in preparation reaction cost and higher in yield, the reaction process is simple and easy to control, so that the naphthoyl amine derivative is suitable for industrial production.
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Description

【Technical field】

[0001] The present invention relates to a kind of naphthyl carboxamide derivative, its preparation method and application. 【Background technique】

[0002] Protein kinases are a class of enzymes that catalyze the phosphorylation of proteins, particularly on specific tyrosine, serine, and threonine residues in proteins. Protein kinases play key roles in regulating many cellular physiological processes, including metabolism, cell proliferation, cell differentiation, cell survival, immune response, and angiogenesis. Many diseases are associated with abnormal cellular responses regulated by protein kinases. These diseases include inflammation, autoimmune diseases, cancer, neurological and neurodegenerative diseases, cardiovascular diseases, metabolic diseases, allergies, asthma and hormone-related diseases (Tan, S-L, 2006, J. Immunol, 176: 2872- 2879; A.eaal.2006, J.Immunol.177:1886-1893; Salek-Ardakani, S.etal.2005, J.Immunol.175:7635-7641; Kim, J.et al.2004,...

Claims

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