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Method for preparing ketose by utilizing aldose

A technology of aldose and ketose, applied in the field of preparing ketose from aldose, achieving important application value, easy industrialization, and easy separation

Active Publication Date: 2013-09-11
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Tewari Y. et al. calculated the equilibrium yield of glucose isomerization from enzyme catalysis to 57% (90°C)-62% (110°C), and none of the above methods exceeded the theoretical equilibrium yield of glucose isomerization

Method used

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  • Method for preparing ketose by utilizing aldose
  • Method for preparing ketose by utilizing aldose
  • Method for preparing ketose by utilizing aldose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1, prepare fructose by glucose

[0046] Add 0.5g of glucose, 1.0g of H-Beta (silicon-alumina ratio of 50) and 50mL of methanol in sequence into a 350mL pressure-resistant tube, seal the pressure-resistant tube, stir and rapidly heat to 90°C for 15 hours to obtain fructoside. Cool the pressure tube, change it to a condensing device and add 100ml of water, stir and rapidly heat to 90°C, recover the methanol solvent, and perform in-situ hydrolysis to generate fructoside. After hydrolysis for 12 hours, cool to room temperature and filter. The conversion rate of glucose in the filtrate is 95% and the yield of fructose is 81%.

[0047] The catalyst used in this example was washed 3 times with water, dried overnight in an oven at 140°C, and reused without further treatment. Experiments were carried out according to the above-mentioned steps, and the conversion rate of glucose was 90%, and the yield of fructose was 76%.

Embodiment 2

[0048] Embodiment 2, fructose is prepared by glucose

[0049] Add 0.5g of glucose, 0.5g of H-Beta (silicon-aluminum ratio of 50) and 50mL of acetonitrile in sequence into a 350mL pressure-resistant tube, seal the pressure-resistant tube, stir and rapidly heat to 90°C for 15 hours to obtain fructoside. Cool the pressure tube, change it to a condensing device and add 100ml of water, stir and rapidly heat to 90°C, recover the solvent, and perform in-situ hydrolysis to generate fructoside. After hydrolysis for 6 hours, it was cooled to room temperature and filtered. The conversion rate of glucose and fructose in the filtrate was detected to be 87% and 66% respectively.

[0050] The catalyst used in this example was washed 3 times with water, dried overnight in an oven at 140°C, and then reused without any other treatment. Experiments were carried out according to the above-mentioned steps, and the conversion rate of glucose was 84%, and the yield of fructose was 62%.

Embodiment 3

[0051] Embodiment 3, fructose is prepared by glucose

[0052] Add 0.5g of glucose, 2.5g of H-Beta (silicon-aluminum ratio of 50) and 50mL of acetone in sequence into a 350mL pressure-resistant tube, seal the pressure-resistant tube, stir and rapidly heat to 90°C for 15 hours to obtain fructoside. Cool the pressure tube, change it to a condensing device and add 100ml of water, stir and rapidly heat to 90°C, recover the solvent, and perform in-situ hydrolysis to generate fructoside. After hydrolysis for 24 hours, cool to room temperature and filter. The conversion rate of glucose in the filtrate is 93% and the yield of fructose is 55%.

[0053] The catalyst used in this example was washed 3 times with water, dried overnight in an oven at 140°C, and reused without any other treatment. Experiments were carried out according to the above-mentioned steps, and the conversion rate of glucose was 89%, and the yield of fructose was 53%.

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Abstract

The invention discloses a method for preparing ketose by utilizing aldose. The method for preparing ketose by utilizing aldose comprises the following steps of: in an organic solvent, carrying out isomerization reaction on aldose under the catalytic action of a molecular sieve based catalyst to obtain glucoside; and carrying out in-situ hydrolysis on the glucoside under the catalytic action of water and the molecular sieve based catalyst to obtain ketose. The invention provides a method for producing ketose by taking low-cost and high-efficiency aldose as a raw material. The method for preparing ketose by utilizing aldose has the advantages that reaction conditions are mild, activity is high, and recovery rates of the catalyst and the solvent are high; the amount of byproducts is low, and yield of a target product is 81%; a molecular sieve and alcohol are respectively taken as the catalyst and the solvent, and economic and environmental costs are low; a heterogeneous catalysis system is adopted, products and the catalyst can be easily separated, aftertreatment is simple, and industrialization is easy to realize.

Description

technical field [0001] The present invention relates to a method for preparing ketose from aldose. Background technique [0002] The isomerization of glucose to fructose is not only the main reaction to generate high fructose syrup, but also a crucial step in the biomass conversion process. Fructose can not only be easily hydrolyzed into fructose, but also an important intermediate that can generate important chemicals such as methyl lactate and methyl levulinate. [0003] Traditionally, the main catalysts for glucose isomerization are enzymes, alkalis, and Lewis acids. The details are as follows: [0004] 1. Enzyme catalysis. Enzyme catalyzed this reaction can obtain high conversion rate and selectivity, such as Bhosale S. et al. obtained 50% glucose, 42% fructose (84% selectivity) and 8 % other sugars. In the existing high fructose syrup production process, most of the glucose isomerization fructose reactions are catalyzed by glucose isomerase. However, enzymes have t...

Claims

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Application Information

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IPC IPC(8): C07H3/02C07H1/00C07C49/17C07C45/42C07B41/06
Inventor 刘海超李腾刘玥
Owner PEKING UNIV
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