Preparation method for enteric plant cellulose hard hollow capsules

A plant cellulose and hollow capsule technology, which is applied in capsule delivery, medical preparations of non-active ingredients, and pharmaceutical formulas, etc., can solve problems such as large water content differences, high water loss, and prolonged drying and molding processes, and achieve molecular Stable structure, sufficient dissolution rate and thorough dissolution effect

Active Publication Date: 2013-10-02
SHAOXING KANGKE CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although gelatin has good properties in the preparation of hollow capsules, the source is limited, and with the frequent occurrence of mad cow disease, foot-and-mouth disease, bird flu and other diseases, the quality problems of gelatin capsules themselves have caused consumers to question and worry
[0003] At present, the following problems are prone to occur in the production process of plant-based hollow capsules: if the raw material of the product has low water content (more solids), the raw material will have poor fluidity and poor homogeneity. Inconsistent and low qualified rate of finished products
If the water content of the product raw materials is increased, the fluidity of the raw materials will be improved, the drying and molding process of the product will be longer, and the power consumption will increase. Moreover, due to the loss of water, the uncertainty of product molding will increase, which will also affect the qualified rate of finished products.
The empty capsules prepared by the existing production process have the disadvantages of different wall thicknesses, large differences in water content, low pass rate, and high energy consumption, and the traditional gelatin empty capsules disintegrate and release within 10 minutes in gastric acid, but the capsules The contents in it are irritating to the stomach, or unstable in case of acid, and need to be disintegrated in the intestine to exert curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Production of transparent colorless enteric-coated cellulose hard hollow capsules

[0022] Take 70 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 30 parts of hypromellose (that is, 30% of the total mass of all ingredients) and slowly add it to the water, stir evenly, and wait until When the liquid temperature drops to about 60°C, add 0.5% (mass ratio) sodium lauryl sulfate and 2% (mass ratio) sodium alginate, and continue stirring. When the temperature of the solution drops below 60°C, stop stirring. Let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven. The temperature of the oven is controlled at 50-70°C and the relative humidity is 40-60%. Coating for the first time, after the coating material is dried, then coating for the second time, then demoulding, cutting, following the conventional hard capsule production proces...

Embodiment 2

[0023] Embodiment 2: Production of colorless transparent enteric-coated cellulose hard hollow capsules

[0024] Take 75 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 25 parts of hypromellose (that is, 25% of the total mass of all ingredients), slowly add it to the water, stir evenly, and wait for When the liquid temperature drops to about 60°C, add 0.3% sodium lauryl sulfate, 0.2% Tween-80 (polysorbate-80), and 1.5% agar, and continue stirring until the solution temperature drops below 60°C , stop stirring, let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven. The temperature of the oven is controlled at 50-70°C and the relative humidity is 40-60%. After 3-4 hours , the first coating is carried out first, and the coating material is dried, and then the second coating is carried out, and then demoulding, cutting, and following the convention...

Embodiment 3

[0025] Example 3: Production of colored light-shielding enteric-coated cellulose hard hollow capsules

[0026] Take 75 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 25 parts of hypromellose (that is, 25% of the total mass of all ingredients), slowly add it to the water, stir evenly, and wait for When the liquid temperature drops to about 60°C, add 0.3% sodium lauryl sulfate, 2% Tween-80 (polysorbate-80), 1.5% agar, 0.3% pigment, 1% titanium dioxide, Continue to stir, when the temperature of the solution drops below 60°C, stop stirring, let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven, the temperature of the oven is controlled at 50-70°C, and the relative humidity is at 40-60%, after 3-4 hours, the first coating is carried out first, and the coating material is dried, and then the second coating is carried out, and then demoulding, cutti...

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PUM

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Abstract

The invention provides a preparation method for hard hollow capsules from enteric plant cellulose derivatives and belongs to the technical field of pharmaceutic adjuvants. Plant cellulose is prepared from plant derivatives such as pine, purified cotton and the like. Colorless and transparent hard hollow capsules, colored hard hollow capsules, shading hard hollow capsules and the like can be prepared though the preparation method. The preparation method comprises steps of mixing of plant cellulose, surfactants, coagulant aids, coloring agents and water, molding, drying, coating and the like. The plant cellulose hard hollow capsules are advantaged by stable performances, low water content, environmental protection and safety. The plant cellulose hard hollow capsules can be filled by all kinds of contents.

Description

technical field [0001] The invention relates to a preparation method of an enteric-coated vegetable cellulose hard hollow capsule, which belongs to the technical field of pharmaceutical auxiliary material processing. Background technique [0002] The hard hollow capsule shell is the main outer packaging material for filling medicine and health food, and it is taken into the body together with the endocytosis, which reduces the trouble of entrance and increases the curative effect. Traditional gelatin capsules use gelatin hydrolyzed from animal skin and bone as the main raw material. Although gelatin has good properties when preparing hollow capsules, the source is limited, and with the frequent occurrence of diseases such as mad cow disease, foot-and-mouth disease, and bird flu, the quality problems of gelatin capsules themselves have caused consumers to question and worry. [0003] At present, the following problems are prone to occur in the production process of plant-bas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38
Inventor 俞三愈俞愈俞学文
Owner SHAOXING KANGKE CAPSULE
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