Preparation of cucurbitacin compounds and application of cucurbitacin compounds to medicines

A technology of cucurbitacins and compounds, which is applied in the field of medicine, can solve the problems of NGF being expensive, having a large relative molecular weight, and not being able to pass through the blood-brain barrier, and achieve significant nerve growth factor-mimicking activity, easy access, new drugs for prevention and treatment The effect of development
CN103360451AInactive Publication Date: 2013-10-23ZHEJIANG UNIV +1
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2013-10-23
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides a preparation method of cucurbitacin compounds, which comprises the following steps: pulverizing and leaching traditional Chinese medicine muskmelon pedicel, carrying out solvent partitioning on the crude leaching sample with a methanol water solution and n-hexane, concentrating, respectively separating the concentrate with a normal-phase silica gel chromatographic column, and purifying by high performance liquid chromatography to obtain the purified cucurbitacin compounds. The cucurbitacin compounds obtained in the invention have obvious quasi-nerve growth factor activity, and can be applied to preparation of medicines for preventing senile dementia and other neurodegenerative diseases and especially to preparation of medicines for treating Alzheimer's disease and other neurodegenerative diseases. The invention develops pharmaceutical application of effective component cucurbitacin compounds. The raw material-traditional Chinese medicine muskmelon pedicel has wide sources and is convenient to take; and the preparation method is simple and can easily implement industrial production. The structural general formula is disclosed in the specification.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation method of cucurbitacin compounds and their application in the preparation of drugs for preventing and treating neurodegenerative diseases such as senile dementia. Background technique

[0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system that occurs in the early and old age and is characterized by progressive dementia and abnormal mental behavior. It is second only to heart disease, tumor and stroke among the causes of death in the elderly. fourth place. According to the 2010 report of the International Alzheimer's Association, there were 35.56 million Alzheimer's patients in the world in 2010, and it is expected to increase to 65.69 million by 2030, and 115 million by 2050. The cost of dementia reached $604 billion in 2010 and continues to increase at an alarming rate. As China's society is gradually aging, Alzheimer's disease...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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