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A kind of preparation method of cefuroxime sodium

A technology for cefuroxime sodium and cefuroxime acid, which is applied in the field of drug synthesis, can solve the problems that cefuroxime sodium crystal particles are not very uniform, the stability needs to be further improved, and the particle size is difficult to control, and the crystallinity of the product is good. , the yield is improved, the effect of easy production control

Active Publication Date: 2016-08-03
珠海保税区丽珠合成制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cefuroxime sodium crystal particles prepared by this method are not very uniform and the particle size is difficult to control, the crystallinity is poor, and the stability needs to be further improved.

Method used

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  • A kind of preparation method of cefuroxime sodium
  • A kind of preparation method of cefuroxime sodium
  • A kind of preparation method of cefuroxime sodium

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Embodiment 1

[0038] This embodiment is the method for preparing cefuroxime sodium provided by the present invention, and the specific process flow chart is shown in Figure 6 , the method includes the following steps:

[0039] 1) Prepare sodium ion solution (sodium acetate and sodium lactate):

[0040] 100ml of ethanol, 10ml of water, 4g of sodium acetate, 11.2g of sodium lactate, dissolved for later use.

[0041] 2) Preparation of acid solution:

[0042] 40g of cefuroxime acid, 300ml of acetone + 10ml of water, dissolve, add 2.8g of activated carbon, stir for 20 minutes, wash the carbon with 40ml of acetone + 2.4ml of water, and set aside the filtrate.

[0043] 3) Crystallization:

[0044] Prepare 200ml of ethanol, add the sodium ion solution and acid solution to the ethanol dropwise at the same time, the dropwise addition is completed in about 30 minutes, and the temperature is controlled at 27-29°C.

[0045] 4) Lotion:

[0046] First wash with a mixed solution of 80ml of absolute e...

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Abstract

The invention provides a preparation method of cefuroxlme sodium. The preparation method of cefuroxlme sodium comprises the following steps of: 1) preparing a cefuroxlme acid solution; and 2) preparing a sodium ion liquid, and adding the cefuroxlme acid solution prepared in the step 1) and the sodium ion liquid prepared in the step 2) into a crystal solvent at the same time for crystallization. Crystal obtained by the preparation method is uniform in particle and high in crystallinity, and stability is also improved.

Description

technical field [0001] The invention belongs to the technical field of drug synthesis, and relates to a preparation method of cephalosporin antibiotics, in particular to a preparation method of cefuroxime sodium. Background technique [0002] Cefuroxime sodium (also known as cefuroxime sodium) is the sodium salt of cefuroxime, and its molecular structure is as follows: [0003] [0004] Cefuroxime sodium belongs to the second-generation cephalosporin antibiotic drug, which has a broad antibacterial spectrum and is effective against most Gram-negative bacteria, including Haemophilus influenzae, Neisseria gonorrhoeae, meningococcus, Escherichia coli, Klebsiella , Proteus mirabilis, Enterobacter, Citrobacter, Salmonella, Shigella, and certain indole-positive denatured bacilli. The antibacterial spectrum against gram-positive bacteria is similar to that of cephalexin, mainly including staphylococci and streptococci. [0005] Cefuroxime sodium is relatively stable to β-lacta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/34
Inventor 宋世丘王一霖张新亚黄滔肖鸿
Owner 珠海保税区丽珠合成制药有限公司