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High-yield co-production method of D-gluconic acid-delta-lactone, mannose and mannitol

A technology of gluconic acid and mannose, applied in chemical instruments and methods, monosaccharides, sugar derivatives, etc., can solve problems such as increasing production process costs, and achieve the effects of improving yield and improving economic benefits

Active Publication Date: 2013-11-13
QINGDAO BRIGHT MOON SEAWEED GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent CN 1528728A discloses a mixture of epimerized glucose-mannose sugar liquid through a chromatographic separation device to obtain a mannose-rich component and a glucose-rich component, and the grape-rich component is repeatedly epimerized. The mannose-rich component is hydrogenated to produce mannitol, which improves the yield of mannitol to glucose, but consumes a lot of steam, which increases the cost of the production process

Method used

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  • High-yield co-production method of D-gluconic acid-delta-lactone, mannose and mannitol

Examples

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Embodiment 1

[0026] The method for high yield co-production of D-glucono-δ-lactone, mannose and mannitol described in this embodiment comprises the following steps, such as figure 1 Shown:

[0027] 1. Dissolve 5.5 kg of crystalline glucose monohydrate (contains one crystal water molecule, 5 kg of dry matter) in 4.5 kg of deionized water to obtain a solution with a concentration of 50%, add hydrochloric acid to adjust the pH to 3.0, and add catalyst ammonium molybdate 5 g, carried out epimerization reaction at 110 ° C for 1 hour, and then desalted and refined by ion exchange resin to obtain a mannose content of 30.5% in the heterogeneous mixture.

[0028] 2. Send the above-mentioned heterogeneous mixed solution into a chromatographic separation device to obtain a mannose-rich component and a glucose-rich component; the mass percentage concentration of mannose and glucose in the mannose-rich component is 17% , wherein the content of mannose in the total sugar is 72%, the concentration in th...

Embodiment 2

[0035] The method for high yield co-production of D-glucono-δ-lactone, mannose and mannitol described in this example comprises the following steps:

[0036] 1. Dissolve 5.5 kg of crystalline glucose monohydrate (containing one crystalline water molecule, 5 kg of dry matter) in 5 kg of deionized water to obtain a solution with a concentration of 47.6%, add hydrochloric acid to adjust the pH to 3.5, and add catalyst ammonium molybdate 5 g was subjected to epimerization at 115°C for 1 hour, and then desalted and refined by ion exchange resin to obtain a mannose content of 30.2% in the heterogeneous mixture.

[0037]2. Desalting and refining the above-mentioned heterogeneous mixed solution through ion exchange resin into a chromatographic separation device to obtain a mannose-rich component and a glucose-rich component; the mannose-rich glucose content in the mannose-rich component The mass percentage concentration is 17%, the content of mannose in the total sugar is 73%, the mas...

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Abstract

The invention discloses a high-yield co-production method of D-gluconic acid-delta-lactone, mannose and mannitol, which comprises the following steps of: firstly, epimerizing glucose into mannose; separating to obtain a glucose-rich component and a mannose-rich component; adding glucose oxidase into the mannose-rich component to obtain a mixed solution of gluconic acid and glucose mannose; separating the mixed solution to obtain a glucose mannose solution and a gluconic acid solution; further preparing D-gluconic acid-delta-lactone from the gluconic acid solution; further preparing a mannose crystal from the glucose mannose solution; performing a hydrogenation reaction of the mother solution to obtain a mixed solution containing sorbitol and mannitol; and performing crystallization and centrifugal separation to obtain a mannitol crystal. The method disclosed by the invention increases the content of mannose in liquid glucose, reduces the content of oligosaccharide in the liquid glucose, and obtains a new byproduct, namely D-gluconic acid-delta-lactone; and mannitol is produced through hydrogenation of a mother solution after the mannose crystallization, so that the increase of oligosaccharide content caused by repeated separation and concentration of the mother solution is avoided.

Description

technical field [0001] The invention belongs to the field of preparation of organic compounds, in particular to a method for co-producing D-glucono-δ-lactone, mannose and mannitol with high yield. Background technique [0002] D-glucono-δ-lactone is currently mainly obtained from gluconate as a starting material, which is obtained by acidification or cationic resin exchange, concentration, and crystallization, which will produce a large amount of waste residue and a large amount of waste water. Patent CN 101607952A discloses a method for preparing D-glucono-δ-lactone from glucose, which uses hydrogen peroxide oxidation followed by electrodialysis separation, which has the advantages of low energy consumption and high yield. [0003] The industrial production of crystalline mannose mainly includes plant extraction and chromatographic separation after glucose epimerization to obtain high mannose components, which are crystallized by organic solvents. Glucose and mannose are c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/02C07H1/00C07H1/06C07C31/26C07C29/141C12P17/06
Inventor 纪伟王暖升尹宗美陈华
Owner QINGDAO BRIGHT MOON SEAWEED GROUP
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