Production method of polylactic acid-trimethylene carbonate nano-fiber film

A technology of methyl carbonate and nanofibers, which is applied in fiber treatment, spinning solution preparation, textiles and papermaking, etc. It can solve the problems of low shape transition temperature, low shape recovery rate, low shape recovery rate of polylactic acid, and unsuitability. To achieve the effect of solving stress shielding

Inactive Publication Date: 2013-11-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still few reports on the preparation of scaffolds with nanofibrous structures using SMP combined with electrospinning technology and the study of their growth behavior on osteoblasts.
[0005] Polylactic acid has excellent biocompatibility, biodegradability, good mechanical properties and shape memory effect, however, its shape transition temperature is high, about 60 ° C, it is not suitable for human body, and the shape of pure polylactic acid The recovery rate is low, so it needs to be copolymerized with other monomers to obtain a shape memory material with a low shape transition temperature and high shape recovery rate, polylactic acid and polyglycolic acid (PGA), polyethylene oxide (PEO), poly Polymers such as ethylene glycol (PEG) and trimethylene carbonate (TMC) can be block copolymerized to obtain shape memory materials, the purpose of which is to achieve an adjustable glass transition temperature of the material (that is, directly affect the shape deformation Adjustable temperature range), adjustable degradation speed, and improved mechanical properties

Method used

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  • Production method of polylactic acid-trimethylene carbonate nano-fiber film
  • Production method of polylactic acid-trimethylene carbonate nano-fiber film
  • Production method of polylactic acid-trimethylene carbonate nano-fiber film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Dissolve 0.2 g of PDLLA-PTMC (DLLA:TMC=50:50, molar ratio) in 0.7 g of DMF and 0.9 g of DCM with an electronic analytical balance, and stir until completely dissolved to obtain the final PDLLA-PTMC PDLLA-PTMC / DMF / CH at a concentration of 11.1% (w / w) 2 CL 2 spinning solution.

[0032] (2) Use a 10mL syringe and a needle with an inner diameter of 1.2mm to extract PDLLA-PTMC / DMF / CH 2 CL 2 The spinning solution was fixed on the electrospinning device for electrospinning. The parameters were: the injection rate of the spinning solution was 2mL / h, the voltage was 15kV, the receiving distance was 15cm, the ambient temperature was 23°C, and the ambient relative humidity was 40%. Aluminum foil was used as the receiving device, and the fiber membrane was spun for 2 hours. The collected fiber membrane was dried in a vacuum oven for 24 hours to obtain a PDLLA-PTMC (50:50) shape memory fiber membrane with a fiber structure.

[0033] The scanning electron micrograph of the PD...

Embodiment 2

[0035] (1) Weigh 0.4g of PDLLA-PTMC (DLLA:TMC=70:30, molar ratio) and dissolve it in 0.8g of DMF and 0.8g of DCM with an electronic analytical balance, and stir until completely dissolved to obtain the final PDLLA-PTMC PDLLA-PTMC / DMF / CH at a concentration of 20% (w / w) 2 CL 2 spinning solution.

[0036] (2) Use a 10mL syringe and a needle with an inner diameter of 1.2mm to extract PDLLA-PTMC / DMF / CH2 CL 2 The spinning solution is fixed on the electrospinning device for electrospinning. The parameters are: the injection rate of the spinning solution is 1.5mL / h, the voltage is 14kV, the receiving distance is 20cm, the ambient temperature is 26°C, and the ambient relative humidity is 45%. . Aluminum foil was used as the receiving device, and the fiber membrane was spun for 2 hours. The collected fiber membrane was dried in a vacuum oven for 24 hours to obtain a PDLLA-PTMC (70:30) shape memory fiber membrane with a fiber structure.

[0037] The scanning electron micrograph of th...

Embodiment 3

[0039] (1) Weigh 0.45g of PDLLA-PTMC (DLLA:TMC=80:20, molar ratio) with an electronic analytical balance and dissolve it in 0.5g of DMF and 1.1g of DCM, and stir until completely dissolved to obtain the final PDLLA-PTMC PDLLA-PTMC / DMF / CH at a concentration of 21.9% (w / w) 2 CL 2 spinning solution.

[0040] (2) Use a 10mL syringe and a needle with an inner diameter of 1.2mm to extract PDLLA-PTMC / DMF / CH 2 CL 2 The spinning solution was fixed on the electrospinning device for electrospinning. The parameters were: the injection rate of the spinning solution was 2mL / h, the voltage was 16kV, the receiving distance was 16cm, the ambient temperature was 25°C, and the ambient relative humidity was 46%. Aluminum foil was used as the receiving device, spinning for 2 hours, and the collected fiber membrane was dried in a vacuum oven for 24 hours to obtain a PDLLA-PTMC (80:20) shape memory fiber membrane with a fiber structure.

[0041] The scanning electron micrograph of the PDLLA-PTMC...

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Abstract

The invention relates to a production method of polylactic acid-trimethylene carbonate nano-fiber film. The method includes: dissolving PDLLA-PTMC (poly-DL-lactic acid and poly trimethylene carbonate) into organic solvent to obtain spinning dope, performing electrospinning, collecting fiber film, and vacuum-drying to obtain the polylactic acid and trimethylene carbonate nano-fiber film. The PDLLA-PTMC is 10%-25%w/w in the spinning dope in terms of concentration. The produced nano-fiber film is shape memory film featuring imitated natural extracellular matrix, and can provide cells with an ideal microenvironment for growth, proliferation and differentiation.

Description

technical field [0001] The invention belongs to the field of preparation of shape memory polymer materials, in particular to a preparation method of polylactic acid-trimethylene carbonate nanofiber film. Background technique [0002] Bone injury is the most common type of tissue injury. At present, there are many methods for repairing bone tissue injury, but for large bone injury, bone transplantation is the best treatment method. In recent years, the development of tissue engineering has changed the development concept of bone graft materials, and the concept of tissue engineered bone triggered by it has expanded the field of bone graft materials. However, the currently developed rigid bone materials and flexible materials that can be applied to bone tissue repair have some problems. For example, the elastic modulus of rigid bone tissue repair materials is much larger than that of normal bone, so that it bears most of the bone during the fixation process. stress, resulting...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H3/005D04H3/16D01D1/02D01D5/00
Inventor 张彦中包敏袁卉华周祺惠董文娄向新
Owner DONGHUA UNIV
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