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Allantoin preparation and application thereof

A technology of allantoin and preparations, which is applied in the direction of antidote, pill delivery, capsule delivery, etc. It can solve the problems of insignificant effect of antiallergic drugs, large side effects, and insignificant effects of diseases, so as to improve people's health and reduce production costs. low and improve people's health

Active Publication Date: 2013-11-27
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0052] In order to solve the problem of insignificant effects and large side effects of current antiallergic drugs and the problem that free radical drugs enter the human body unstable and have no obvious effect on diseases caused by free radicals, the present invention provides an allantoin preparation, which has an antiallergic effect Obviously, no side effects and stable in the human body are not easy to be destroyed, and have obvious effects on diseases caused by free radicals

Method used

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  • Allantoin preparation and application thereof
  • Allantoin preparation and application thereof
  • Allantoin preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0068] Embodiment 1 (based on 1000g)

[0069] Preparation of allantoin tablets

[0070] Prescription composition: allantoin 500.0g, starch 180.0g, dextrin 300.0g, tartaric acid 10.0g, 50% ethanol 200-400ml, magnesium stearate 10.0g, 5000 tablets (allantoin content 0.1g / tablet);

[0071] Preparation method: Weigh 500.0g of allantoin powder, 280.0g of starch, and 300.0g of dextrin and mix evenly, dissolve 10.0g of tartaric acid in 200-400ml of ethanol with a concentration of 50%, and then add the prepared tartaric acid solution to the powder at one time, When adding, the dispersion surface should be large, mixed evenly, made into soft materials according to conventional pharmaceutical methods, passed through 18-20 mesh sieves to make wet granules, dried at 60°C, and raised to 70°C when nearly dry, accelerated drying, moisture control of dry granules When the weight is less than 1.5%, sieve the granules with the same mesh when making wet granules, sieve out the fine powder in th...

Embodiment 2

[0082] Preparation of allantoin oral solution (based on 1000g)

[0083] Prescription composition: allantoin 2g, sodium bicarbonate 1g, citric acid 1g, distilled water added to 1000ml (g);

[0084] Preparation method: Dissolve 2 g of allantoin, 1 g of sodium bicarbonate and 1 g of citric acid in 1000 ml (g) of distilled water, stir well, finely filter, sub-package, and sterilize with radiation to obtain allantoin oral liquid, which can also be used externally ;

[0085] Usage: Take orally, 10-20ml each time, 3 times a day, or scrub the affected part of the skin 3 times a day, according to the clinical disease diagnosis based on the standard of cure and improvement (the second edition compiled by the Ministry of Health of the General Logistics Department of the Chinese People's Liberation Army) treatment time 1- After 8 weeks, the cure means that the rash has disappeared by 98%, the marked effect means that the rash has disappeared by 60%, and the effective means that the rash ...

Embodiment 3

[0091] Preparation of allantoin effervescent capsules (based on 1000g)

[0092] Prescription composition: allantoin 500g, sodium bicarbonate 100g, citric acid 100g, lactose 300g;

[0093] Preparation method: Dry allantoin and sodium bicarbonate at a temperature of 60°C for 2 hours, and citric acid (citric acid) at a temperature of 105°C for 1 hour, respectively grind and pass through a 100-mesh sieve. Thoroughly mix bursin, sodium bicarbonate, citric acid and lactose, grind them evenly, pass through a 100-mesh sieve, and pack 5,000 No. 3 hollow capsules;

[0094] Take it orally or take it after brewing, 1 capsule each time, 3 times a day, according to the clinical disease diagnosis based on the standard of cure and improvement (the second edition compiled by the Ministry of Health of the General Logistics Department of the Chinese People's Liberation Army), the treatment time is 1-4 weeks, and the curative effect statistics See the table below:

[0095]

[0096] Typical c...

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Abstract

The invention relates to an allantoin preparation. The allantoin preparation is an allantoin tablet, allantoin capsule, allantoin oral liquid or allantoin nasal drop which contains allantoin and auxiliary materials and is prepared by the conventional preparation method, wherein the auxiliary materials are starch, dextrin, tartaric acid, ethanol with concentration of 50 percent, magnesium stearate, lactose, distilled water and a sodium bicarbonate antioxidant enhancer or lemon antioxidant enhancer; every 1,000 g of allantoin preparation comprises 2-500 g of allantoin and 500-998 g of auxiliary materials. The invention also relates to anti-allergic application of the allantoin preparation in preparation of anti-allergic medicaments and application in preparation of free radical scavenging medicaments; the allantoin preparation has an obvious anti-allergic effect, has no side effects, is stable and not damaged easily in human bodies and has an obvious effect on diseases caused by free radicals.

Description

technical field [0001] The invention relates to an allantoin medicine and its use, in particular to the use of allantoin in the preparation of anti-allergic and anti-oxidation medicines. Background technique [0002] Allantoin is widely found in tobacco seeds, sugar beet, wheat germ, urine film fluid and other animal and plant kingdoms. The chemical name of allantoin is 1-ureido-diazolanedione-[2,4], and its structural formula is: [0003] [0004] Pure allantoin is a white odorless and tasteless crystalline powder, soluble in hot water, hot alcohol and dilute sodium hydroxide solution, slightly soluble in warm water and alcohol, hardly soluble in organic solvents such as ether and chloroform, it is non-toxic and non-irritating Sexual, non-allergic, once known as anti-irritants. [0005] In medicine: Allantoin has physiological functions such as promoting cell growth, accelerating wound healing, and softening keratin. It is a good healing agent and anti-ulcer agent for s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/20A61K9/08A61K31/4166A61P37/08A61P39/06A61P11/02A61P11/06A61P11/00A61P35/02A61P9/10A61P19/02
CPCA61K9/0007A61K9/0043A61K9/0095A61K9/2059A61K9/4858A61K31/4166A61K47/02A61K47/12
Inventor 许可许博然
Owner 许可