Unlock instant, AI-driven research and patent intelligence for your innovation.

Thiol-containing compounds for the removal of elements from tissues and formulations therefor

By forming stable covalent bonds between the new sulfur-containing chelating agent ligands and heavy metals, it solves the problems of unstable heavy metal treatment and toxic release in the existing technology, achieves safe excretion under various environmental conditions, and significantly improves the treatment effect. .

Inactive Publication Date: 2013-12-11
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, such chelators would have low or no measurable toxicity themselves to mammals not exposed to heavy metals

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0158] This example illustrates the synthesis of a non-limiting embodiment of AB9 by the following scheme:

[0159]

[0160] Will be obtained from Sigma-Aldrich 0.78 g of L-cysteine ​​hydrochloride (5.0 mmol) was dissolved in 100 mL of deionized water. 1.02 grams of triethylamine (10mmol, 1.4mL) (hereinafter referred to as "TEA") and obtained from TCI 0.5 g of isophthaloyl dichloride (2.5 mmol) were each dissolved in Acros Organics 20 mL of tetrahydrofuran (hereinafter referred to as "THF"). TEA dissolved in THF was slowly added to a deionized aqueous solution of L-cysteine ​​hydrochloride, which was placed in a flask under N 2 Stir under airflow. After stirring for 5 to 10 minutes, isophthaloyl chloride dissolved in THF was slowly added to the flask. As the reaction progressed, the color of the reaction mixture turned pale yellow. The reaction mixture was stirred for an additional 16 to 18 hours. At the end of 16 to 18 hours, the aqueous layer was extracted with ...

Embodiment 2

[0162] This example illustrates the synthesis of a non-limiting embodiment of MEAB9 by the following scheme:

[0163]

[0164] Dissolve 2.75 g of L-cysteine ​​methyl ester hydrochloride (15 mmol) in 150 mL of CHCl 3 middle. Dissolve 1.52 g of TEA (15 mmol, 2.07 mL) in 25 mL of CHCl 3 middle. Dissolve 1.0 g of isophthaloyl chloride (5 mmol) in 40 mL of CHCl 3 middle. The TEA solution and the isophthaloyl chloride solution were slowly added to the L-cysteine ​​methyl ester hydrochloride solution. The reaction was stirred for 24 hours. The reaction solution was then filtered, and the filtrate was washed with 200 mL of 10% Omnitrace Wash with hydrochloric acid three times. After washing, CHCl 3 layer was filtered again and subjected to anhydrous Na 2 SO 4 dry. CHCl was then removed under vacuum 3 , the product was obtained as a highly viscous oily liquid. The oily liquid was redissolved in CHCl 3 and then remove CHCl under vacuum 3 . This process was repeated t...

Embodiment 3

[0166] This example illustrates the synthesis of a non-limiting embodiment of EEAB9 by the following scheme:

[0167]

[0168] Dissolve 2.72 g of L-cysteine ​​ethyl ester hydrochloride (15 mmol) in 150 mL of CHCl 3 middle. Dissolve 1.48 g of TEA (15 mmol, 2.02 mL) in 25 mL of CHCl 3 middle. Dissolve 1 g of isophthaloyl chloride (5 mmol) in 40 mL of CHCl 3 middle. The TEA solution and the isophthaloyl chloride solution were slowly added to the L-cysteine ​​ethyl ester hydrochloride solution. The reaction was stirred for 24 hours. Then filter the reaction solution, the filtrate with 1.5L 20% Omnitrace Hydrochloric acid cleaning. After washing, CHCl 3 layer was filtered again and subjected to anhydrous Na 2 SO 4 dry. CHCl was then removed under vacuum 3 , the product was obtained as a highly viscous oily liquid. The oily liquid was redissolved in CHCl 3 and then remove CHCl under vacuum 3 . This process was repeated twice, and the resulting white solid was was...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and / or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The ligands are of the general structure: where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of U.S. Patent Application No. 12 / 892,464, filed September 28, 2010, which is a continuation-in-part of International Patent Application No. PCT / US10 / 50512, filed September 28, 2010 , the entire disclosure of which is incorporated herein in its entirety. technical field [0003] The present invention relates to compounds for covalent bonding to various metals and main group elements, and more particularly to sulfur-containing ligands and their use for the removal of pollutants from solids, liquids and gases. Background technique [0004] Heavy metal and main group element pollution is an existing and growing worldwide problem. Over the past few decades, federal and state governments have enacted environmental regulations to protect the quality of surface and groundwater from contamination. In response to the requirements of these environmental regulations, a variety of produ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/16A61K31/095A61K9/20A61K9/16A61K9/06
CPCA61K31/198A61K31/216A61K31/695A61K31/795B01D53/64B01D2253/106B01D2253/25B01D2257/602B01D2258/0283B01D2258/0291C07F7/1804A61P39/02A61P39/04A61P43/00
Owner UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com