Multifunctional medical biological bone cement

Abstract

The invention discloses multifunctional medical biological bone cement. The multifunctional medical biological bone cement is prepared from the following raw materials in percentage by mass: 5%-15% of polyacrylic acid microspheres, 20% of bioactive glass, 64.9%-74.9% of calcium phosphate bone cement and 0.1% of nanometer alendronate sodium microspheres, wherein the sum of the mass percentages of the raw materials is 100%. The multifunctional medical biological bone cement has the function of water absorption self-expansion; the using amount of the bone cement can be reduced, and further the leakage of the bone cement is reduced; the multifunctional medical biological bone cement has relatively good tissue compatibility, can be used for inducing the formation of new bones and enhancing the strength of vertebral bodies, is degradable in vivo without in vivo foreign matter residues; and meanwhile, the controlled-release alendronate sodium has the effects of resisting osteoporosis, reducing the absorption of bones and furthering enhancing the vertebral bodies. Therefore, the multifunctional medical biological bone cement has the advantages of little consumption, promotion of bone formation and bone absorption resistance when applied to vertebroplasty.

Description

technical field [0001] The invention relates to a medical biological filling material, in particular to a multifunctional medical biological bone cement, which is especially suitable for repairing vertebral body compression fractures or bone defects under the condition of osteoporosis. Background technique [0002] As the worldwide population ages, the number of osteoporotic vertebral compression fractures (OVCF) caused by osteoporosis continues to increase. What's more serious is that the kyphosis deformity caused by the fracture changes the trunk line, which increases the risk of vertebral fractures in adjacent segments, forming a vicious cycle of "fracture-deformation-re-fracture", which seriously affects the physical and mental health of the elderly and quality of life. [0003] Percutaneous vertebroplasty and percutaneous kyphoplasty are classic minimally invasive surgical procedures widely used in the treatment of vertebral compression fractures. Their common purpose ...

AI Technical Summary

Problems solved by technology

[0004] At present, the most commonly used biological material for vertebroplasty is polymethyl methacrylate (PMMA) bone cement, which is widely used in clinic because of its good operability, biocompatibility, chemical stability and good mechanical properties. , but the function of PMMA bone cement is single, it only relies on its mechanical strength to restore the height of the vertebral body to play a supporting role, and the elastic modulus of PMMA bone cement is high, which changes the stress distribution between vertebral bodies and easily leads to refracture of adjacent vertebral bodies; and in It is non-degradable and absorbed in the body, and remains in the body for life; at the same time, excessive heat production and possible leakage of PMMA bone cement in clinical applications cause damage to the nerve tissue around the injured site; in addition, PMMA bone cement has no anti-osteoporosis effect, neither Promote the formation of new bone without inhibiting bone resorption, so the etiology of osteoporotic vertebral compression fractures cannot be fundamentally resolved

[0005] At present, there are no new bone cement materials that can locally inhibit bone resorption, anti-osteoporosis, and treat vertebral compression fractures at home and abroad.

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