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Preparation method for porous nano-composite support material of bone tissue engineering

A bone tissue engineering and nano-composite technology, applied in the field of biomedical composite materials, can solve the problems that cannot meet the requirements of artificial bone, collagen and hydroxyapatite cannot be used as structural materials, etc., to improve biomechanical properties and facilitate adhesion Attachment growth and vascularization, and the effect of improving the toughness of the material

Inactive Publication Date: 2014-01-01
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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Problems solved by technology

However, because the bone itself is a natural nanocomposite material with high toughness and hardness, it is mainly composed of nanoscale sheet-like hydroxyapatite crystals dispersed in the bone collagen skeleton, and bone collagen and hydroxyapatite themselves are both It cannot be used as a structural material, so the artificial bone with Nano-HA as a single component still cannot meet the requirements of an ideal artificial bone

Method used

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  • Preparation method for porous nano-composite support material of bone tissue engineering
  • Preparation method for porous nano-composite support material of bone tissue engineering
  • Preparation method for porous nano-composite support material of bone tissue engineering

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Embodiment Construction

[0023] Preferred specific embodiments of the present invention are provided below to help further illustrate the present invention, but the protection scope of the present invention is not limited to these examples.

[0024] The technical scheme of the preparation method of the porous nanocomposite bone tissue engineering scaffold material in this embodiment is as follows:

[0025] 1. Synthesis of Nano-HA by sol-flocculation method.

[0026] 2. PLLA was synthesized by ring-opening polymerization.

[0027] 3. The porous nanocomposite scaffold material was synthesized by low temperature rapid prototyping technology.

[0028] Wherein, the synthetic method of described Nano-HA is as follows:

[0029] The aqueous solution of calcium nitrate and ammonium phosphate is chemically synthesized. During the synthesis process, a certain amount of ammonia water is added to adjust the pH value of the solution to 8-13. Add a dispersant and stir to make the precipitation complete. Then, the ...

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Abstract

The invention relates to biomedical composites, particularly to a preparation method for a porous nano-composite support material of bone tissue engineering. The scheme of the invention is that the preparation method comprises the following steps: mixing Nano-HA ((Hydroxy-apatite) and PLLA (Polylactic acid) materials at the temperature of 50-70 DEG C, carrying out ultrasonic oscillation, and then performing electromagnetic stirring until the NAno-HA is uniformly and completely dispersed to obtain gel; transferring the gel to the environment with the temperature of minus 5 DEG C to minus 3 DEG C to be subjected to low-temperature formation, and filling biological materials, so as to obtain the porous nano-composite support material of the bone tissue engineering. According to the method, provided by the invention, a three-dimensional porous Nano-HA / PLLA artificial bone can be prepared through the combination of the Nano-HA and the PLLA; the three-dimensional porous artificial bone support material integrates the advantages of both the Nano-HA and the PLLA, the flexibility, biodegradability and biomechanical property are improved, adhesion growth and vascularization of bone cells can be better facilitated, and the healing speed and effect of bone defect parts with transplanted artificial bones are greatly improved.

Description

technical field [0001] The invention relates to a biomedical composite material, in particular to a preparation method of a porous nanocomposite bone tissue engineering scaffold material. Background technique [0002] The research and development of bone tissue engineering provides a new idea for the repair and treatment of clinical bone defects, and gradually arouses the interest of researchers. Among them, the three-dimensional porous scaffold material is an important basis for bone tissue engineering. It not only acts as a support to maintain the shape of the original tissue, but also acts as a template, providing a place for cells to lodge, grow, differentiate and proliferate, thereby Guides the regeneration of damaged tissue and controls the structure of the regenerated tissue. However, the research and application of bone tissue engineering scaffolds still face many problems, such as uncontrollable degradation of materials in vivo, low cell reproduction efficiency, in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/18A61L27/56A61L27/58
Inventor 王大平黄江鸿熊建义朱伟民刘建全尤微段莉张巨峰陈洁琳
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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