Fuyanping vaginal expansion suppository and its preparation method and detection method

The technology of vaginal expansion suppository and expansion suppository is applied in the directions of suppository delivery, pharmaceutical formulations, material inspection products, etc., which can solve the problems of poor solubility, difficult cleaning, and splintering of traditional Chinese medicine compositions, achieve fast drug release speed, and avoid secondary infection. , the effect of increasing stability

The technology of vaginal expansion suppository and expansion suppository is applied in the directions of suppository delivery, pharmaceutical formulations, material inspection products, etc., which can solve the problems of poor solubility, difficult cleaning, and splintering of traditional Chinese medicine compositions, achieve fast drug release speed, and avoid secondary infection. , the effect of increasing stability

CN103494873BActive Publication Date: 2016-04-20哈尔滨田美药业股份有限公司
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  • Fuyanping vaginal expansion suppository and its preparation method and detection method
  • Fuyanping vaginal expansion suppository and its preparation method and detection method
  • Fuyanping vaginal expansion suppository and its preparation method and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109]

[0110] Preparation:

[0111] 1) Preparation of drug-containing matrix:

[0112] a. Putting Poloxamer, Tween 65 and glycerol triabietate in a water bath for heating and melting to obtain a melt;

[0113] b. the preparation of Chinese medicine composition:

[0114] Ⅰ. Weigh the Sophora flavescens and Bitterwood in the prescribed amount, crush them, and decoct them in water three times. The amount of water added for the first time is 10 times of the total weight of Sophora Sophorae and Bitterwood, and boiled for 3 hours. The amount of water added for the second time is 5 times the total weight of bitter wood, decoct for 2 hours, add water for the third time 3 times the total weight of flavescens and bitter wood, decoct for 1.5 hours, combine the decoction liquid, filter, concentrate the filtrate to a thick paste, and spray dry it into powder;

[0115] Ⅱ. Take the Fructus Cnidii of prescription quantity, pulverize, add 75% ethanol and reflux to extract twice, the am...

Embodiment 2

[0121]

[0122] Preparation:

[0123] 1) Preparation of drug-containing matrix:

[0124] a. placing polyoxyethylene monostearate and glycerol trilaurate in a water bath for heating and melting to obtain a melt;

[0125] b. the preparation of Chinese medicine composition:

[0126] Ⅰ. Weigh the Sophora flavescens and Bitterwood in the prescribed amount, crush them, and decoct them in water three times. The amount of water added for the first time is 10 times of the total weight of Sophora Sophorae and Bitterwood, and boiled for 3 hours. The amount of water added for the second time is 5 times the total weight of bitter wood, decoct for 2 hours, add water for the third time 3 times the total weight of flavescens and bitter wood, decoct for 1.5 hours, combine the decoction liquid, filter, concentrate the filtrate to a thick paste, and spray dry it into powder;

[0127] Ⅱ. Take the Fructus Cnidii of prescription quantity, pulverize, add 75% ethanol and reflux to extract twice...

Embodiment 3

[0134]

[0135] Preparation method: Prepare 100 torpedo-shaped suppositories according to the method described in Example 2, each weighing about 5.0 g.

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Abstract

The invention relates to a Fuyanping vaginal expansion suppository and a preparation method and a detection method thereof. The expansion suppository includes a drug-containing matrix and an expansion carrier formed by a Chinese medicine composition and a matrix; the Chinese medicine composition includes Sophora flavescens, bitter wood, etc. 9 raw materials, and cockscomb and loofah are also added in the Chinese medicine composition, and the Fuyanping vaginal expansion suppository made has a good curative effect on gynecological diseases such as trichomonal vaginitis; the Chinese medicine composition The drug-containing microemulsion is made with polyoxyethylene 40 hydrogenated castor oil, potassium stearate and ethylene glycol monooleate, which can improve the solubility of the traditional Chinese medicine composition, thereby improving the bioavailability of Fuyanping vaginal expansion suppository; Making the expansion plug into a hollow expansion plug can improve its stability; the meglumine can also improve the stability of the drug-containing microemulsion; and the Fuyanping vaginal expansion plug adopts six original leading technologies, which can prevent The medicinal liquid flows out, has high stability, long-lasting curative effect, and prevents secondary infection and other beneficial effects.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Fuyanping vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Fuyanping preparation composed of sophora flavescens, cnidium fruit, bitter wood, dried alum, nacre powder, borneol, menthol, berberine hydrochloride and boric acid has the effects of clearing away heat and detoxification, drying dampness and stopping belt, killing insects and relieving itching, It is generally used for leukorrhea, vulva itching, excessive leukorrhea, yellowish smell, and genital itching caused by hot and humid betting; vaginitis and vulvitis caused by trichomonas, mold, and bacteria see the above symptoms. [0003] At present, Fuyanping preparations commonly used clinically include Fuyanping Capsules, Fuyanping Vaginal Effervescent Tablets, Fuyanping Suppositories and other dosage forms. Among them, Fuyanping Vaginal Effervescent Tab...

Claims

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Application Information

Patent Timeline
20 Apr 2016
Publication
CN103494873B
IPC
A61K36/489; A61K47/14; A61K47/44; A61K47/34; A61K47/42; A61K47/26; A61K9/02; A61P15/02; A61P15/00; A61P31/02; A61P33/02; G01N33/15; G01N5/04; A61K31/045; A61K31/4375; A61K33/06; A61K35/618; A61K33/22; A61K47/10
Inventors
邱学良; 邱明世