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Pharmaceutical composition for facilitating feces excretion and clearing bowels

A composition and drug technology, applied in the field of laxative and bowel cleansing pharmaceutical compositions, can solve the problems of abdominal distension, allergies, frequent diarrhea and other adverse reactions, low intestinal infection rate, high intestinal cleansing rate, etc., to achieve effective Conducive to clinical treatment of constipation, low intestinal infection rate, and high intestinal cleansing effect

Active Publication Date: 2014-01-22
STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the many adverse reactions such as nausea, vomiting, abdominal pain, abdominal distension, allergies, frequent diarrhea, etc. that exist in the existing pharmaceutical composition containing polyethylene glycol for laxative and bowel cleansing, and to reduce the recurrence rate of constipation. High, with the disadvantages of producing a large number of air bubbles for bowel cleansing, high intestinal lumen infection rate, long time to complete bowel cleansing, and poor compliance, a drug combination containing polyethylene glycol for laxative and bowel cleansing is provided Adverse reactions such as nausea, vomiting, abdominal pain, abdominal distension, allergies, frequent diarrhea, etc. are few after administration of the composition, the recurrence rate of constipation is low, no air bubbles are produced when used for bowel cleansing, the intestinal cleansing rate is high, and the intestinal cavity infection rate is low And the time required to complete bowel cleansing is short, and the compliance rate is high

Method used

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  • Pharmaceutical composition for facilitating feces excretion and clearing bowels
  • Pharmaceutical composition for facilitating feces excretion and clearing bowels
  • Pharmaceutical composition for facilitating feces excretion and clearing bowels

Examples

Experimental program
Comparison scheme
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preparation Embodiment 1

[0031] Present embodiment illustrates powder dosage form of the present invention, and formula is as follows:

[0032]

[0033] The preparation method is as follows:

[0034] 1) Pulverize polyethylene glycol 4000 and pass through a 60-mesh sieve to obtain polyethylene glycol 4000 fine particles with a particle size (D90) of 250 μm for use;

[0035] 2) Mix the electrolyte according to the ratio of sodium bicarbonate, potassium chloride and sodium chloride in the formula, crush it, and pass it through a 100-mesh sieve to obtain electrolyte fine particles with a particle size (D90) of 150 μm for use;

[0036] 3) Grinding the fructo-oligosaccharide and passing it through a 100-mesh sieve to obtain fine granules of fructo-oligosaccharide with a particle size (D90) of 150 μm for later use;

[0037] 4) Weigh polyethylene glycol 4000 fine particles, electrolyte fine particles and fructooligosaccharide fine particles respectively according to the formula;

[0038] 5) Mix the weigh...

preparation Embodiment 2-8

[0041] This example illustrates the powder dosage form of the present invention, and the powder of the present invention is prepared according to the formula shown in Table 1 and according to the method of Preparation Example 1.

[0042] Table 1

[0043]

preparation Embodiment 9

[0045] Present embodiment illustrates granule of the present invention, and formula is as follows:

[0046]

[0047] According to the above formula and according to the method of preparation example 1 step 1)-5), the mixed fine particles of fructooligosaccharide polyethylene glycol electrolyte are obtained, and 95% ethanol aqueous solution is sprayed on it, and the dosage is relative to the fructooligosaccharide polyethylene glycol electrolyte. 10% by weight of the total amount of mixed fine particles of alcohol electrolyte, made into soft materials, then granulated with a 40-mesh sieve, boiled and dried in a fluidized bed at 10°C-60°C for 20 minutes, and granulated with a 40-mesh sieve to obtain a particle size (D90) is 380 μm polyethylene glycol electrolyte particles containing fructooligosaccharides, and the obtained particles are divided into 1000 bags and sealed to obtain the finished product.

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Abstract

The invention provides a pharmaceutical composition for facilitating feces excretion and clearing bowels. The composition comprises polyethyleneglycol and fructooligosaccharide in a weight ratio of 0.656:1-5.250:1, and optionally comprises one or more alkali earth metal salts capable of maintaining osmotic pressure and electrolyte balance. The pharmaceutical composition has greatly lower polyethyleneglycol content and comprises fructooligosaccharide; and thus, the pharmaceutical composition reduces the untoward effects, such as nausea, vomit, bellyache, abdominal distention, allergy, frequent diarrhea and the like, and has the advantages of low recurrence rate when being used for treating constipation, low bubble generate tendency, high cleanness of intestinal tracts, low intestinal cavity infection rate, short time required by cleaning the intestinal tracts, and high compliance rate when being used for clearing the bowels, thereby being beneficial to clinical treatment of constipation and preoperative intestinal tract cleaning preparation.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for laxative and bowel cleansing. Background technique [0002] Polyethylene Glycol (PEG) is a high molecular polymer obtained by polymerization of ethylene oxide. It has the effect of laxative and bowel cleansing clinically. The specific mechanism of action is: after polyethylene glycol enters the body through oral administration, it binds and fixes the inherent water molecules in the intestinal cavity through hydrogen bonds, increases the water content of the feces, increases the volume and weight of the feces, softens the feces, and promotes the stool in the intestinal cavity. It can improve constipation, restore stool volume and weight to normal, and promote the final completion of defecation, thereby improving constipation symptoms; at the same time, because its laxative and bowel cleansing effects are physical effects, therefore, polyethylene gly...

Claims

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Application Information

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IPC IPC(8): A61K31/765A61P1/10A61K31/702
Inventor 谭剑平李艳梅常坦然蒋立新周志文
Owner STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD