Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof

The technology of vaginal expansion suppository and Baicaofu is applied in the field of Baicaofuyanqing vaginal expansion suppository and its preparation, and can solve the problems of easily polluted clothes, no expansion effect of cotton sliver, great change in melting time, etc., and avoid secondary problems. Effects of infection, expansion of administration area, and improvement of compliance

Active Publication Date: 2014-01-22
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The soft capsule suppository improves the stability of the suppository, and the effervescent suppository improves the curative effect of the suppository on the deeper part of the vagina; in the prior art, there are many kinds of Chinese medicinal materials in the Baicaofuyanqing suppository, and after being made into a preparation, the traditional Chinese medicine The release of the material is unstable, which affects the curative effect of the suppository; in addition, the traditional Baicaofuyanqing suppository releases the drug quickly, and the effective administration time is short, and there are "peaks and valleys"; the tampon in the suppository has no swelling effect, or has no swelling effect It is not easy to clean, and it is easy to contaminate clothes; the quality control method is unreliable, which leads to technical problems such as large changes in content, stability, and melting time limit between batches in the actual production process

Method used

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  • Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof
  • Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof
  • Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111]

[0112] Preparation:

[0113] 1) Preparation of drug-containing matrix:

[0114] a. Place glycerol tristearate, propylene glycol stearate, and tallow tallow in a water bath for heating and melting to obtain a melt;

[0115] b. the preparation of Chinese medicine composition:

[0116] I weigh the flavescens of the prescribed amount, crush it, add water to decoct three times, the first water consumption is 15 times of the weight of flavescens, decoct for 2 hours, and the second water consumption is 5 times of the weight of flavescens, decoct for 2 hours , the third water consumption is 5 times of the weight of Sophora flavescens, decoct for 1 hour, combine the decoction, filter, the filtrate is concentrated to a clear paste with a temperature of 25 °C and a relative density of 1.08; add 50% ethanol, and the amount of ethanol used is 10 times the weight of the clear paste, let it stand for precipitation, take the supernatant to recover ethanol, concentrate to a thick...

Embodiment 2

[0124]

[0125] Preparation method: make 100 bullet-shaped suppositories according to the method in Example 1, each weighing about 4.2g.

Embodiment 3

[0127]

[0128] 1) Preparation of drug-containing matrix:

[0129] a. placing lauric triglycerides, mixed fatty acid glycerides and cocoa butter in a water bath for heating and melting to obtain a melt;

[0130] b. the preparation of Chinese medicine composition:

[0131] I weigh the Sophora flavescens of the prescribed amount, crush it, add water and decoct three times, the first water consumption is 10 times the weight of Sophora flavescens, decoct for 3 hours, and the second water consumption is 10 times the weight of Sophora flavescens, decoct for 1 hour , the third water consumption is 5 times of the weight of Sophora flavescens, decocted for 1 hour, combined the decoction, filtered, and the filtrate was concentrated to a clear paste with a temperature of 25 °C and a relative density of 1.10; adding 90% ethanol, the amount of ethanol used was The thick paste with a relative density of 1.35 is 105% of the weight of the clear paste, and the thick paste is passed through...

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Abstract

The invention relates to a Baicao expandable vaginal suppository for clearing gynecologic inflammation, and a preparation method and a detection method thereof. The expandable suppository comprises a traditional Chinese medicine composition, a matrix and an expansion carrier. The traditional Chinese medicine composition and the matrix form a medicine-containing matrix, which is coated on the surface of the expansion carrier. The traditional Chinese medicine composition is prepared from sophora root, the tuber of stemona, Fructus Cnidii, agrimony, Folium Callicarpae Formosanae, alum, borneol, camphor and boric acid; and the medicine-containing matrix includes an acidifier and hydrogenated lecithin, which cooperate to promote absorption of the traditional Chinese medicine composition. The expandable vaginal suppository is prepared into an osmotic pump expandable vaginal suppository, which has the function of zero level slow release, so as to fully play the therapeutic effect of the expandable suppository. And the Baicao expandable vaginal suppository employs seven unique technologies, and has the beneficial effects of prevention of outflow liquid, high stability, lasting effect and prevention of secondary infection.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Baicaofuyanqing vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Baicao Fuyanqing Suppository (also known as Baixian Fuyanqing Suppository), recorded in the "National Compilation of Chinese Patent Medicine Standards Surgical Gynecology Subvolume", consists of Sophora flavescens 640g, Baibu 320g, Cnidium 320g, Agrimony 320g, Zizhu It is prepared from 320g of leaves, 10g of alum, 5g of borneol, 10g of camphor, 60g of boric acid, 2600g of glycerin and 950g of gelatin. The curative effect of Baicao Fuyan Qing Suppository has been clinically proven for many years. It has the functions of clearing heat and detoxifying, killing insects and relieving itching, removing blood stasis and astringent. It is widely used in fungal vaginitis, bacterial vaginosis, trichomonas vaginitis and cervical erosion. [0003] The prio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/02A61K47/32A61K47/24A61K47/36A61K47/12A61P15/02A61P15/00A61P31/04A61P31/10A61P33/02G01N33/15G01N30/02G01G17/00A61K33/06A61K33/22A61K31/125A61K31/045
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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