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Flomoxef sodium composition freeze-dried powder for injection

A technology for using fluoroox cephalosporin sodium and fluorooxycephate sodium is applied in the field of freeze-dried powder injection of fluorooxycephate sodium composition, which can solve the problem of no chitosan-containing nanoparticles and the like, achieve easy portability and transportation, biological The effect of high utilization and safety guarantee

Inactive Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no pharmaceutical dosage form containing chitosan nanoparticles clinically at present.

Method used

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  • Flomoxef sodium composition freeze-dried powder for injection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 fluoxetal sodium composition freeze-dried powder for injection (with 1000)

[0025] 1. Prescription

[0026] Fluoxetal Sodium 200g

[0027] Chitosan Nanoparticles 100g

[0028] Water for injection 2000mL

[0029] 2. Preparation process

[0030] (1) Weigh 200 g of fluoxetal sodium and 100 g of chitosan nanoparticles, slowly add 1500 mL of 70° C. water for injection, and stir until dissolved while adding.

[0031] (2) Use buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate to adjust the pH to 4.5, add water for injection to the resulting solution to the full amount, then add 0.1 g of activated carbon and stir for 30 minutes, filter the activated carbon, and then pass the liquid through 0.45 μm and Filter through a 0.22μm microporous membrane, detect the content of the intermediate, and calculate the filling amount according to 0.2g per bottle.

[0032] (3) Fill according to the test requirements, put it into a f...

Embodiment 2

[0033] The preparation (with 1000) of fluoxetal sodium composition lyophilized powder for injection of embodiment 2

[0034] 1. Prescription

[0035] Fluoxetin Sodium 500g

[0036] Chitosan Nanoparticles 250g

[0037] Water for injection 2000mL

[0038] 2. Preparation process

[0039] (1) Weigh 500 g of fluoxetal sodium and 250 g of chitosan nanoparticles, slowly add 1500 mL of 70° C. water for injection, and stir until dissolved while adding.

[0040] (2) Use buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate to adjust the pH to 4.5, add water for injection to the resulting solution to the full amount, then add 0.1 g of activated carbon and stir for 30 minutes, filter out the activated carbon, and then pass the liquid through 0.45 μm and Filter through a 0.22μm microporous membrane, detect the content of the intermediate, and calculate the filling amount according to 0.1g per bottle.

[0041] (3) Fill according to the test requirements, put it in...

Embodiment 3

[0042] The preparation of embodiment 3 fluoxetal sodium composition freeze-dried powder for injection (with 1000)

[0043] 1. Prescription

[0044] Fluoxetal Sodium 200g

[0045] Chitosan Nanoparticles 100g

[0046] Water for injection 2000mL

[0047] 2. Preparation process

[0048] (1) Weigh 200 g of fluoxetal sodium and 100 g of chitosan nanoparticles, slowly add 1500 mL of 70° C. water for injection, and stir until dissolved while adding.

[0049] (2) Use buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate to adjust the pH to 4.5, add water for injection to the resulting solution to the full amount, then add 0.1 g of activated carbon and stir for 30 minutes, filter out the activated carbon, and then pass the liquid through 0.45 μm and Filter through a 0.22 μm microporous membrane, detect the content of the intermediate, and calculate the filling amount according to 40 mg per bottle.

[0050] (3) Fill according to the test requirements, put it in...

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Abstract

The invention provides a flomoxef sodium composition freeze-dried powder for injection, and belongs to the field of medicine and medicine preparation technology. The flomoxef sodium composition freeze-dried powder comprises following raw material ingredients, by weight, 50 to 500 parts of flomoxef, 25 to 250 parts of chitosan nanoparticle, and 2000 parts of injection water. The flomoxef sodium composition is prepared by mixing flomoxef sodium with chitosan nanoparticle at an appropriate ratio, and is made into freeze-dried powder injection to be used as a novel antibacterial medicine in clinic. Advantages of the flomoxef sodium composition freeze-dried powder are that: (1) production technology is advanced, the flomoxef sodium composition freeze-dried powder is stable, and storage life is long; (2) effect is realized quickly, and antimicrobial activity is increased because of synergistic effect; (3) bioavailability is high, and half-life period is long; (4) the flomoxef sodium composition freeze-dried powder is safe for application, curative effect is accurate, and quality is controllable; and (5) dosage is accurate, and application is convenient.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a freeze-dried powder injection of fluoxefor sodium composition for injection. Background technique: [0002] Fluoxefor sodium is a white to pale yellow-white powder. Odorless, easily soluble in water or methanol, soluble in ethanol or absolute ethanol, almost insoluble in ether. The antibacterial spectrum mainly includes Staphylococcus aureus, Streptococcus (except Enterococcus), Streptococcus pneumoniae, Peptostreptococcus, catarrhalis, Neisseria gonorrhoeae, Escherichia coli, Klebsiella, Proteus, Haemophilus influenzae and Bacteroides etc. This product is an Oxycephem antibiotic with a broad antibacterial spectrum, and has high antibacterial activity against Gram-positive cocci (except Enterococcus) and most Enterobacteriaceae bacteria. [0003] Intravenous infusion of 0.5g, 1g or 2g of this product lasted for 1 hour, the highest blood concentratio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/36A61K31/5365A61K31/722A61P31/04
Inventor 汪六一汪金灿吴函峰
Owner HAINAN WEI KANG PHARMA QIANSHAN