Method for preparing polypeptide copolymer porous nanofiber by using electrostatic spinning

A technology of electrospinning and nanofibers, which is applied in the direction of spinning solution preparation, single-component copolyamide artificial filament, fiber treatment, etc., can solve problems such as constraints and poor cell adhesion performance, and achieve good biophase Capacitance, effect of promoting cell adhesion and growth
CN103590133AInactive Publication Date: 2014-02-19EAST CHINA UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
EAST CHINA UNIV OF SCI & TECH
Publication Date
2014-02-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for preparing polypeptide copolymer porous nanofiber by using electrostatic spinning. The method comprises the following steps: firstly, carrying out hydrophilic modification on a hydrophobic polypeptide homopolymer to prepare a poly(gamma-benzyl L-glutamate-hydroxyethyl glutamine) or poly(gamma-benzyl L-glutamine)-g-polyethylene glycol grafted copolymer; secondly, preparing a compound solvent by using solvents with different volatilization properties, and then preparing into a spinning solution; thirdly, spinning by using a high voltage electrostatic spinning method; and finally, placing spun yarns into a vacuum drying chamber and drying for more than 3 hours at room temperature to obtain the porous nanofiber with high specific surface area. A cytotoxicity test indicates that the prepared porous nanofiber with high specific surface area is free of cytotoxicity and good in biocompatibility, can be used as a porous scaffold for cell growth, has the function of promoting cell migration and amplification and has a relatively good application value in the aspect of preparation of scaffolds for tissue engineering; besides, the polypeptide copolymer porous nanofiber has an application prospect in the fields of medical dressing, medicine released control, artificial organs, sewage treatment and the like.
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Description

technical field

[0001] The invention relates to the technical field of preparation of functional fibers, in particular to a method for preparing porous nanofibers of polypeptide copolymers by electrospinning. Background technique

[0002] After the 1990s, with the continuous development of nanotechnology, electrospinning has become one of the main methods for preparing nanofibers. Electrospinning is a method in which a polymer solution or melt is sprayed and stretched under electrostatic action to obtain nano or micron fibers. The materials that can be used for electrospinning are very wide, including most synthetic polymers and some natural polymer materials, such as chitosan and gelatin. Synthetic polypeptides are a class of excellent biodegradable materials. They have no toxic side effects on organisms, have the same main chain structure as natural proteins, and have good biocompatibility. They are widely used in drug sustained release and medical adhesives. and other b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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