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Ammonium glycyrrhizinate compound and pharmaceutical composition containing ammonium glycyrrhizinate

A monoammonium glycyrrhizinate compound technology, applied in the field of medicine, can solve the problems of poor solubility in hot water and poor water solubility, and achieve the effect of good resolubility, high solubility and easy dissolution

Inactive Publication Date: 2014-03-05
弘和制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Yet the water solubility of monoammonium glycyrrhizinate adopted in the preparation in the prior art is relatively poor, only dissolves in hot water, is more difficult to dissolve in hot water

Method used

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  • Ammonium glycyrrhizinate compound and pharmaceutical composition containing ammonium glycyrrhizinate
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  • Ammonium glycyrrhizinate compound and pharmaceutical composition containing ammonium glycyrrhizinate

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Effect test

Embodiment 1

[0039] Embodiment 1, the preparation of monoammonium glycyrrhizinate compound

[0040] Take monoammonium glycyrrhizinate (C 42 h 65 NO 16 2H 2O) 50g of raw material drug, add N,N-dimethylformamide / ethanol mixed solvent, wherein the ratio of monoammonium glycyrrhizinate raw material drug to mixed solvent is 1g:6ml, N,N-dimethylformamide in the mixed solvent The volume ratio of formamide to ethanol is 1:3, then add 0.10g of activated carbon, stir for adsorption, filter for decarbonization and sterilization to obtain a clear solution. Reflux at 45°C for 2 hours, cool down to 30°C, keep warm, and add chloroform dropwise at a stirring rate of 25r / min. The volume ratio of the chloroform to the mixed solvent is 3:1. After the dropwise addition, continue to keep warm and stir After 20 min, the stirring was stopped, the temperature was lowered to 0°C, and the mixture was allowed to stand at this temperature for 2 hours, filtered, washed with ethanol three times, and dried under red...

Embodiment 2

[0042] Embodiment 2, the preparation of monoammonium glycyrrhizinate compound

[0043] Take monoammonium glycyrrhizinate (C 42 h 65 NO 16 2H 2 O) 50g of raw material drug, add N,N-dimethylformamide / ethanol mixed solvent, wherein the ratio of monoammonium glycyrrhizinate raw material drug to mixed solvent is 1g:10ml, N,N-dimethylformamide in the mixed solvent The volume ratio of formamide to ethanol is 1:5, then add 0.10 g of activated carbon, stir for adsorption, filter for decarbonization and sterilization, and obtain a clear solution. Reflux at 50°C for 3 hours, cool down to 40°C, keep warm, and add chloroform dropwise at a stirring rate of 30r / min, the volume ratio of chloroform to mixed solvent is 7:1, continue to keep warm and stir after the dropwise addition After 30 minutes, the stirring was stopped, the temperature was lowered to 5°C, and the mixture was allowed to stand at this temperature for 6 hours, filtered, washed with ethanol three times, and dried under red...

Embodiment 3

[0045] Embodiment 3, the preparation of monoammonium glycyrrhizinate compound

[0046] Take monoammonium glycyrrhizinate (C 42 h 65 NO 16 2H 2 O) 50g of raw material medicine, add N,N-dimethylformamide / ethanol mixed solvent, wherein the dosage ratio of monoammonium glycyrrhizinate raw material medicine and mixed solvent is 1g:8ml, N,N-dimethylformamide in mixed solvent The volume ratio of formamide to ethanol is 1:4, then add 0.10g of activated carbon, stir for adsorption, and filter to decarbonize and sterilize to obtain a clear solution. Reflux at 47°C for 2.5h, cool down to 34°C, keep warm, and add chloroform dropwise at a stirring rate of 28r / min. The volume ratio of chloroform to mixed solvent is 5:1, and keep warm after the dropwise addition Stir for 25 minutes, then stop stirring, cool down to 2°C, let stand at this temperature for 3 hours, filter, wash with ethanol three times, and dry under reduced pressure for 3 hours to obtain the obtained product.

[0047] The...

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Abstract

The invention belongs to the technical field of a medicine, and particularly relates to an ammonium glycyrrhizinate compound and a pharmaceutical composition containing the ammonium glycyrrhizinate compound. The ammonium glycyrrhizinate compound disclosed by the invention is crystal, and is determined by a powder X-ray diffraction measurement method, the molecular formula is C42H65NO16.2H2O; an X-ray powder diffraction pattern represented by a diffraction angle of 2theta+ / -0.2 degrees is shown in the figure 1. The pharmaceutical composition provided by the invention contains the ammonium glycyrrhizinate compound disclosed by the invention, cysteine hydrochloride and pharmaceutical acceptable auxiliary materials, and preferably comprises the following components in parts by weight: 1-200 parts of ammonium glycyrrhizinate, 1-200 parts of cysteine hydrochloride, 1-1,000 parts of sodium chloride, 1-200 parts of anhydrous sodium sulfite and 1-100 parts of edetate disodium. The ammonium glycyrrhizinate compound disclosed by the invention has good solubility in water, and is fast in dissolution rate, good in redissolution ability, and convenient to use, and the medication safety of a sufferer is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a monoammonium glycyrrhizinate compound and a pharmaceutical composition containing monoammonium glycyrrhizinate. Background technique [0002] Hepatitis is a common and frequently-occurring disease. According to incomplete statistics, hepatitis patients and virus carriers account for 10% of the total population in my country. Among them, viral hepatitis is the main type, and viral hepatitis can be divided into: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Chronic hepatitis can be divided into two categories: persistent hepatitis and active hepatitis: [0003] (1) Persistent hepatitis: The course of anicteric hepatitis persists for more than half a year, which is persistent hepatitis. The course of the disease is mild, with mild fatigue and gastrointestinal symptoms, dull pain in the liver area, swelling in mild cases, and mild abnormality or re...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/704A61P1/16A61P29/00A61K31/198
Inventor 郑建勇苏大明田慧
Owner 弘和制药有限公司
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