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Preparation method of fluorescent gold nanocluster functionalized with fluorescent probe folic acid

A technology of fluorescent gold nanometer and probe folic acid, applied in fluorescence/phosphorescence, chemical instruments and methods, nanotechnology for materials and surface science, etc., can solve the problems of low sensitivity and poor reproducibility, and achieve high sensitivity, The effect of low detection limit and simple method

Active Publication Date: 2016-04-20
蚌埠格识知识产权运营有限公司
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Problems solved by technology

[0003] For the detection of metal ions, the traditional methods of inductively coupled plasma (ICP) and atomic absorption spectrometry are very effective, but they require a large number of samples in addition to large instruments.
In addition, there is a method of colorimetric determination using a complexing agent and a colored complex with ions, but its sensitivity is low and the reproducibility is poor, so it is rarely used now
In recent years, the use of organic fluorescent molecules as detection probes to detect heavy metal ions has achieved good results, but organic fluorescent molecular probe technology is applied to the detection of transition metals and heavy metal ions, which can realize in situ detection, but many fluorescent probes usually It has a good detection effect in organic solvents, but has certain limitations in aqueous solutions

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  • Preparation method of fluorescent gold nanocluster functionalized with fluorescent probe folic acid
  • Preparation method of fluorescent gold nanocluster functionalized with fluorescent probe folic acid
  • Preparation method of fluorescent gold nanocluster functionalized with fluorescent probe folic acid

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Embodiment Construction

[0024] Below in conjunction with specific embodiment, further illustrate the present invention.

[0025] A method for preparing fluorescent gold nanoclusters functionalized with fluorescent probe folic acid, characterized in that it comprises the following steps:

[0026] First, mix 1-5mL of 30mM chloroauric acid solution with 20-50mL of water and heat it to 70-100°C. Under the condition of magnetic stirring, add 2-5mL of 0.2-1% folic acid aqueous solution to make the color of the mixed solution change from pale to The yellow color gradually turns to dark brown. After the reaction proceeds for about 10-30 minutes, the mixed solution is cooled to room temperature, centrifuged at about 6000-8000 rpm for about 10 minutes, and the supernatant obtained is fluorescent gold nanoclusters.

[0027] The prepared fluorescent gold nanoclusters exhibit blue light emission under the ultraviolet light source, and its fluorescence spectrum is excited at a wavelength of 275nm, and the fluoresc...

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Abstract

The invention provides a method for synthesizing a folic acid functionalized fluorogold nano-cluster by using folic acid as a reducing agent. The size of the folic acid functionalized fluorogold nano-cluster is 3-7 nanometers, and radiates blue light under an ultraviolet source; that a method for detecting heavy metal mercury ions by using the folic acid functionalized fluorogold nano-cluster as a fluorescent probe is researched, the result shows that the folic acid functionalized fluorogold nano-cluster has high sensitivity and selectivity for the mercury ions, can be used as the fluorescent probe to detect the mercury ions, and meanwhile, has relatively good environmental suitability. In addition, the method for synthesizing the folic acid functionalized fluorogold nano-cluster adopts a simple one-step green synthesis route, so that the method provided by the invention has the characteristics that the cost is low, the synthetic method is simple, and the operation is easy. The method for detecting the mercury ions by using the folic acid functionalized fluorogold nano-cluster as the detection probe is simple in operation, and can quickly and quantitatively detect mercury with the heavy metal ions.

Description

technical field [0001] The invention belongs to the technical field of nanometer detection, and in particular relates to a method for synthesizing fluorescent gold nanoclusters. Background technique [0002] Heavy metal pollution refers to environmental pollution caused by heavy metals or their compounds. Among heavy metal ions, mercury is a highly toxic but ubiquitous pollutant in nature. Mercury pollution can cause serious damage to the brain, nervous system, endocrine system, and kidneys. Water-soluble divalent mercury ion (Hg 2+ ) is one of the most common and stable forms of mercury pollutants, which is the main way of water environment and soil pollution. It is mainly caused by human factors such as mining, exhaust gas discharge, sewage irrigation and use of heavy metal products. Inorganic mercury can be converted to methylmercury by bacteria in the environment, and this form of mercury contamination can be passed on or accumulated in higher organic organisms throu...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/58G01N21/64B82Y20/00B82Y30/00B82Y40/00
Inventor 柴芳苏东悦王春刚吴晓彤杨馨夏清冬
Owner 蚌埠格识知识产权运营有限公司
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