Omeprazole nano emulsion and preparation method thereof
An omeprazole and nanoemulsion technology, applied in the field of omeprazole nanoemulsion and its preparation, can solve the problems of low bioavailability, poor water solubility, inconvenient storage and the like, and achieves simple preparation process, convenient operation and moderate price Effect
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Embodiment 1
[0042] A kind of omeprazole nanoemulsion, is made up of following raw material:
[0043] Omeprazole API 5g
[0044] soybean oil 160g
[0045] Tween-80 250g
[0046] 1,2 propylene glycol 110g
[0047] Water for injection 475g
[0048] Total 1000g
[0049] The preparation method of above-mentioned omeprazole nanoemulsion is as follows:
[0050] (1) At room temperature, weigh the omeprazole raw material according to the formula ratio and dissolve it in 1,2 propylene glycol, then add Tween-80 and soybean oil in the formula amount, mix well and set aside;
[0051] (2) Use the formulated amount of water for injection as the water phase. Slowly add water for injection into the system at room temperature while stirring continuously until a clear and transparent liquid is formed, that is, the particle size is 10-100 nanometers, and the appearance is clear and uniform. Omeprazole nanoemulsion.
Embodiment 2
[0053] A kind of omeprazole nanoemulsion, is made up of following raw material:
[0054] Omeprazole API 10g
[0055] Ethyl Oleate 200g
[0056] Castor oil polyoxyethylene ether (EL-40) 170g
[0057] PEG-400 185g
[0058] Water for injection 435g
[0059] Total 1000g
[0060] The preparation method of above-mentioned omeprazole nanoemulsion is as follows:
[0061] (1) At room temperature, weigh the omeprazole raw material according to the formula ratio and dissolve it in PEG-400 first, then add castor oil polyoxyethylene ether (EL-40) and ethyl oleate in the formula amount, mix uniform spare;
[0062] (2) Use the water for injection of the formula amount as the water phase, slowly add the above water for injection into the system at room temperature, and keep stirring until a clear and transparent liquid is formed, that is, the particle size is 10-100 nanometers, and the appearance is clear. Uniform omeprazole nanoemulsion.
Embodiment 3
[0064] A kind of omeprazole nanoemulsion, is made up of following raw material:
[0065] Omeprazole API 1g
[0066] Isopropyl myristate (IPM) 240g
[0067] Polyoxyethylene ether hydrogenated castor oil (RH-40) 280g
[0068] PEG-600 135g
[0069] Water for injection 344g
[0070] Total 1000g
[0071] The preparation method of above-mentioned omeprazole nanoemulsion is as follows:
[0072] (1) At room temperature, weigh the omeprazole raw material according to the formula ratio, dissolve it in PEG-600 first, and add the formula amount of polyoxyethylene ether hydrogenated castor oil (RH-40) and isopropyl myristate (IPM), mix well and set aside;
[0073] (2) Use the formulated amount of water for injection as the water phase. Slowly add the above-mentioned water for injection into the system at room temperature while stirring continuously until a clear and transparent liquid is formed, that is, to obtain a particle size of 10-100 nanometers and a clear appearance. Uniform ...
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