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Pour-on preparation for resisting dermatophyte and preparation method of pour-on preparation

A technology for dermatophytes and pouring agents, applied in the directions of antifungal agents, anti-inflammatory agents, skin diseases, etc., can solve the problems of complex compound process and high cost, and achieve simple preparation process, long lasting effect and convenient administration. Effect

Active Publication Date: 2014-03-19
SICHUAN AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gallnut is often used together with other traditional Chinese medicines to treat skin ringworm. The compound process is complicated and the cost is high

Method used

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  • Pour-on preparation for resisting dermatophyte and preparation method of pour-on preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 0.56g gallic gall extract and dissolve it in 30ml of 1,2-propanediol, then add 2ml of azone, 1ml of Tween-80, 67ml of 90% ethanol in succession, and mix well; then divide the finished product Sealed in vials, about 5~20ml per bottle. After testing, the properties of this pouring agent are off-white, transparent and slightly viscous liquid, and the pH, loading capacity and microbial limit are all qualified.

Embodiment 2

[0030] Dissolve 1.67g of Galla Chinese medicinal extract in 40ml of 1,2-propanediol, then add 4ml of azone, 0.5ml of Tween-80, 55.5ml of 90% ethanol in succession, and mix well; then the finished product Packed in vials and sealed, about 5~20ml per bottle. After testing, the properties of this pouring agent are off-white, transparent and slightly viscous liquid, and the pH, loading capacity and microbial limit are all qualified.

Embodiment 3

[0032] Take 5g of Galla Chinese medicinal extract and dissolve it in 50ml of 1,2-propylene glycol, then add 6ml of azone, 2ml of Tween-80, and 42ml of 90% ethanol in succession, and mix well; then distribute the finished product in Sealed in vials, about 5~20ml per bottle. After testing, the properties of this pouring agent are off-white, transparent and slightly viscous liquid, and the pH, loading capacity and microbial limit are all qualified.

[0033] 1, the pouring agent that embodiment 1-embodiment 3 makes has carried out following anti-dermatophyte drug efficacy test:

[0034] The test temperature was 20°C, repeated 3 times, and the concentration of 100% pouring agent was used to act on Candida albicans, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypsum for 20 minutes. The killing effect is shown in Table 1.

[0035] Table 1 The killing effect of the pouring agents prepared in Examples 1-3 on Candida albicans, Trichophyton mentagrophytes, Microsporum...

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Abstract

The invention discloses a pour-on preparation for resisting dermatophyte. The pour-on preparation for resisting dermatophyte is characterized by being prepared by a step: dissolving 0.56g-5g of gallnut extract in every 100ml of a mixed solvent, wherein the 100ml of the mixed solvent consists of the following components: 2ml-6ml of a permeation enhancer, 0.5ml-2ml of solubilizer, 30ml-50ml of a solvent, and the balance of an auxiliary agent. The pour-on preparation disclosed by the invention has the advantages that main medicinal materials are uniformly dispersed, and the pour-on preparation is transparent slightly-sticky liquid, convenient to dose, long in persistent effect, small in toxic and side effects, satisfies requirements of Chinese pharmacopoeia, and is controllable in quality. Pharmacodynamics study indicates that the pour-on preparation has prevention and treatment effect on dermatomycosis caused by dermatophyte infection, and has an auxiliary treatment effect on subsequent inflammation due to fungal infection.

Description

technical field [0001] The invention relates to an anti-dermatophyte pour-on and a preparation method thereof, in particular to a traditional Chinese medicine pour-on for preventing and treating dermatophytosis caused by dermatophyte infection and a preparation method thereof. Background technique [0002] Dermatophyte is one of the diseases harmful to the animal breeding industry caused by filamentous fungus invading the cuticle of the skin and its appendages. Highly contagious zoonotic contact skin disease, also known as "dermatophytosis". This disease mainly affects animal fur, and symptoms such as increased dander, scab, hair loss, exudation, folliculitis and itching appear, and severe cases can cause body malnutrition, growth retardation, and reduced feed remuneration, which directly affect the output and quality of fur. Quality, reduce the production performance of animals and the survival rate of cubs, caused serious economic losses to the breeding industry. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P31/10A61P17/00A61P29/00
Inventor 殷中琼贾仁勇李曼徐娇宋旭向发陈振振李莉
Owner SICHUAN AGRI UNIV
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