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Preparation method of micro-nano bioactive porous material

A bioactive and porous material technology, applied in the field of preparation of porous materials, can solve the problems of porogen residues and other problems, and achieve the effects of convenient operation, easy control of porosity and pore size, and good connectivity

Inactive Publication Date: 2014-03-19
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the particle filtration method is widely used because of its simplicity, but the porogen residue is its main disadvantage.

Method used

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  • Preparation method of micro-nano bioactive porous material
  • Preparation method of micro-nano bioactive porous material

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preparation example Construction

[0025] Such as figure 1 As shown, the preparation method of the micro-nano bioactive porous material disclosed by the present invention comprises steps:

[0026] (1) Mix tetrahydrofuran and dimethylformamide at a ratio of 3:1 by volume, and use the resulting mixture as a solvent, and add poly(lactic-co-glycolic acid) (referred to as PLGA) to the solvent under stirring , fully dissolved and made into a solution with a concentration of 8-12% w / v;

[0027] (2) Sonicate a 1×2cm silicon wafer with isopropanol for 15 minutes, take it out, put it into a mixed solution with a volume ratio of ammonia:hydrogen peroxide:distilled water=1:1:5, and heat it to 70°C. Stop heating, count for 10 minutes, then cool naturally, and clean the silicon wafer;

[0028] (3) Measure melamine-formaldehyde resin microsphere suspensions of different particle sizes, spread them on the treated silicon wafers, completely disperse and dry them; place the silicon wafers on the receiving plate of the electros...

Embodiment 1

[0045] (1) Add 1.2 grams of poly(lactic-co-glycolic acid) copolymer (the following examples are referred to as PLGA) into a mixed organic solvent with a volume ratio of tetrahydrofuran and dimethylformamide of 3:1 under stirring, and fully dissolve it. Prepare a solution with a concentration of 8% (w / v);

[0046] (2) Sonicate a 1×2cm silicon wafer with isopropanol for 15 minutes, take it out, put it into a mixed solution with a volume ratio of ammonia:hydrogen peroxide:distilled water=1:1:5, and heat it to 70°C. Stop heating, count for 10 minutes, then cool naturally, and clean the silicon wafer;

[0047] (3) Measure 10 μL of melamine-formaldehyde resin microsphere (MF) suspension with a particle size of 2 μm, spread it on the treated silicon wafer, disperse and dry it completely. Put the silicon wafer on the receiving plate of the electrospinning device, and perform electrospinning with the PLGA solution obtained above, the receiving distance is 10cm, the voltage is 15kV, an...

Embodiment 2

[0050] (1) Add 1.2 grams of poly(lactic-co-glycolic acid) copolymer (the following examples are referred to as PLGA) into a mixed organic solvent with a volume ratio of tetrahydrofuran and dimethylformamide of 3:1 under stirring, and fully dissolve it. Prepare a solution with a concentration of 10% (w / v);

[0051] (2) Sonicate a 1×2cm silicon wafer with isopropanol for 15 minutes, take it out, put it into a mixed solution with a volume ratio of ammonia:hydrogen peroxide:distilled water=1:1:5, and heat it to 70°C. Stop heating, count for 10 minutes, then cool naturally, and clean the silicon wafer;

[0052] (3) Measure 10 μL of melamine-formaldehyde resin microsphere (MF) suspension with a particle size of 2 μm, spread it on the treated silicon wafer, disperse and dry it completely. Put the silicon wafer on the receiving plate of the electrospinning device, and perform electrospinning with the PLGA solution obtained above, the receiving distance is 15cm, the voltage is 20kV, a...

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Abstract

The invention discloses a preparation method of a micro-nano bioactive porous material. The preparation method comprises the following steps: adding PLGA (Poly Lactic-co-Glycolic Acid) into a solvent of tetrahydrofuran and dimethyl formamide in a volume ratio of 3:1 under a stirring state to prepare liquor with concentration of 8%w / v-12%w / v; carrying out ultrasonic treatment for 15 minutes onto a silicon wafer by isopropyl alcohol, taking out the silicon wafer and adding into liquor of ammonia water, hydrogen peroxide and distilled water in the volume ratio of 1:1:5 for heating to 70 DEG C, cooling after stopping heating, and cleaning the silicon wafer; measuring and spreading melamine formaldehyde resin microsphere suspension liquid on the silicon wafer; carrying out electrostatic spinning onto the silicon wafer by PLGA liquor, and drying a nano fiber felt after spinning is completed; soaking the dried silicon wafer spun with the nano fiber felt into hydrochloric acid with pH equal to 1, dissolving MF (Melamine-Formaldehyde) microspheres after 0.5 hour-2 hours, completely separating the silicon wafer from the electrostatic-spinning nano fiber felt, cleaning the fiber felt, and drying in vacuum to obtain the porous material. The preparation method disclosed by the invention is simple in process, convenient to operate, easily controllable in porosity and pore size, and good in connectivity of pores.

Description

technical field [0001] The invention relates to the field of preparation of porous materials, in particular to a preparation method of micro-nano bioactive porous materials. Background technique [0002] In recent years, research on tissue engineering has also made great strides because of their unlimited potential in promoting human health. Taking tissue engineering as an example, the defect or dysfunction of tissues and organs caused by disease and trauma is one of the main hazards facing human health. How to overcome the shortcomings of "repairing trauma with trauma" and insufficient donor sources in autologous or allogeneic tissue and organ transplantation, and fundamentally solve the problems of tissue and organ defect repair and functional reconstruction, has become an international frontier in the field of life sciences topic. The preparation of porous materials with excellent properties is one of the key technologies in tissue and organ repair engineering. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/18
Inventor 刘福娟徐岚何吉欢
Owner SUZHOU UNIV