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Polypeptide colon-targeted drug delivery preparation and preparation method thereof

A colon-targeted drug delivery and colon-targeted technology, which is applied in pharmaceutical formulations, anti-toxins, anti-tumor drugs, etc., can solve problems such as unseen research reports, and achieve the goal of enhancing phagocytosis, improving medication compliance, and avoiding pain Effect

Inactive Publication Date: 2014-03-26
TIANJIN JIAHONG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no colon-targeted preparation of blood protein polypeptide in the domestic market, and there is no research report on this preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The method for preparing the colon-targeted drug delivery preparation of the blood protein polypeptide of the present invention comprises the following steps:

[0037] The first step is to prepare a medicinal powder containing blood protein polypeptide components;

[0038] The second step is to place the medicinal powder in a centrifugal coating granulator, spray the mass concentration (g / mL) of 40-60% sucrose syrup to moisten the medicinal powder, control the spraying flow rate, and blast dry at 40-70°C to obtain 60-80 mesh ball core;

[0039] The third step is to use the ethanol solution of 1-5% vidone K30 as the binder with the mass concentration (g / mL), and spray the powder to the ball core with the powder supply machine, and control the feed ratio of the binder and the powder so that The pellet core is enlarged to 10-3000μm pellets, dried and sieved to obtain drug-containing pellets;

[0040] The fourth step is to prepare the colon-targeted coating solution;

[...

Embodiment 1

[0043] Weigh spare 20 grams of blood protein polypeptide freeze-dried powder, 10 grams of red dates, 0.2 grams of vitamin B, mix them into a compound medicinal powder, put them in a centrifugal coating granulator, then spray 50% sucrose syrup to moisten, 40 ~ 70 ℃ Blow drying for 4 hours to obtain 60-80 mesh pellet cores, use 3% povidone K30 ethanol solution as binder, and spray powder to the pellet cores from a powder supply machine to increase the pellet cores to a diameter of 500-800 μm Pellets are dried and sieved to obtain drug-containing pellets. The percentage by weight of each component is controlled as follows: compound medicinal powder 60%, sucrose 25%, povidone K30 15%.

[0044] Weigh 60 grams of acrylic resin S100, add it to 800 milliliters of 80% ethanol solution, stir to dissolve, then add 7 grams of triethyl citrate and 12 grams of talcum powder in turn, stir and mix, and pass the resulting solution through a 80-mesh steel sieve After that, the pH-dependent co...

Embodiment 2

[0047] Weigh spare 25 grams of blood protein peptide freeze-dried powder, 4 grams of Lycium barbarum raw material, 1.2 grams of vitamin B, mix them into a compound drug powder, put it in a centrifugal coating granulator, and then spray 50% sucrose syrup to moisten, 40~ Air-dried at 70°C for 4 hours to obtain 60-80 mesh pellet cores, using 3% povidone K30 ethanol solution as a binder, and spraying powder to the pellet cores from a powder supply machine to increase the pellet cores to 100-80 mesh. The 500μm pellets are dried and sieved to obtain the drug-containing pellets. The weight percentage of each component is controlled as follows: 92% of compound medicinal powder, 5% of sucrose, and 303% of povidone K.

[0048] Weigh 60 grams of acrylic resin, wherein the weight ratio of acrylic resin S100 and acrylic resin L100 is 1:1.5, add it to 800 milliliters of 80% ethanol solution, stir and dissolve, then add 11 grams of triethyl citrate and 4 grams of talc in sequence powder, st...

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Abstract

The invention discloses a colon-targeted drug delivery preparation of hemalbumin polypeptide, which is an orally taken preparation for releasing the drug at a colon part, and prepared by coating a drug-containing pellet containing the hemalbumin polypeptide component with colon-targeted coating liquor or directly filling the drug-containing pellet into a colon-targeted capsule shell, wherein the drug-containing pellet consists of the following components in parts by weight: 60-92 parts of drug powder containing the hemalbumin polypeptide component, 5-25 parts of sucrose, 3-15 parts of povidone K30; and the drug powder comprises the following components in parts by weight: 10-100 parts of hemalbumin polypeptide and 0-90 parts of other drugs and / or nutrients. The preparation disclosed by the invention is a colon release drug with target zone drug concentration higher than that of other tissues, enters blood circulation through the colon, can effectively avoid metabolism destruction of peptide drugs of common orally-taken preparation in the stomach to bring treatment effect of the drug into full play, and is safe and convenient to take orally.

Description

technical field [0001] The invention belongs to the technical field of preparation of biological drugs, and relates to a colon-targeting preparation, more specifically, a colon-targeting preparation of blood protein polypeptide and a preparation method thereof. Background technique [0002] Blood meal is divided into plasma powder and blood cell powder, of which blood cells account for 2 / 3. my country is very rich in blood meal resources. If the blood of more than 1 billion livestock slaughtered each year can be effectively recovered, more than 200 million kg of blood cell meal can be produced each year. But at present, except for a small part of the blood after slaughtering for food or feed or for the production of heme, superoxide dismutase, and thrombin in biochemical pharmaceuticals, a large part is directly discharged as waste, polluting the environment. Therefore, how to rationally utilize the animal blood in the slaughterhouse and increase its use value is very impor...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K35/14A61K45/00A61K9/16A61K9/52A61K47/38A61P7/06A61P37/04A61P39/06A61P35/00
Inventor 郭丽
Owner TIANJIN JIAHONG TECH
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