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Preparation method of structure size-controllable hydroxyapatite powder for plasma thermal spraying

A technology of hydroxyapatite and nano-hydroxyapatite, which is applied in the direction of nanotechnology, chemical instruments and methods, and phosphorus compounds for materials and surface science, and can solve the problem of obtaining hydroxyapatite hollow microspheres, The problems of low crystallinity of hydroxyapatite powder and low hollow ratio of hydroxyapatite can reduce the difficulty of preparation, improve the rheological properties and reduce the cost

Active Publication Date: 2014-04-16
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with this method, the concentration of the original slurry needs to be strictly controlled, otherwise it is difficult to obtain hollow microspheres of hydroxyapatite, and the hollow rate of hydroxyapatite in the obtained product is low
CN1903706A discloses a preparation method of hydroxyapatite hollow microspheres, adopts chemical precipitation method to prepare hydroxyapatite slurry, and adds pore-forming agent ammonium bicarbonate (NH 4 HCO 3 ) to spray-dry to obtain hydroxyapatite hollow microspheres composed of nanocrystalline particles, but the effect of pore-forming agent content on the hollow rate of the powder is not explained
CN1597610A sprays hydroxyapatite porous microspheres into ice-water mixture by plasma spheroidization method, and obtains a kind of hydroxyapatite hollow microspheres with hollow center and porous wall, and the hydroxyapatite prepared by this method Stone powder with low crystallinity
CN102807202A prepared hydroxyapatite hollow microspheres by hydrothermal reaction with DNA template method. By changing the amount of DNA added, the cavity size of hydroxyapatite hollow spheres can be effectively adjusted, but the efficiency of the template method is low, and it is difficult to achieve large mass production

Method used

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  • Preparation method of structure size-controllable hydroxyapatite powder for plasma thermal spraying
  • Preparation method of structure size-controllable hydroxyapatite powder for plasma thermal spraying
  • Preparation method of structure size-controllable hydroxyapatite powder for plasma thermal spraying

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Weigh 94g of deionized water and add it to the ball mill tank, add 10g of ammonium polyacrylate solution (40% by mass percentage concentration, the following concentrations are all mass percentage concentrations unless otherwise specified), take 100g of nano-hydroxyapatite and mix it, Prepare slurry (solid content 50%), ball mill for 5 hours, add 6g of polyethylene glycol, and continue ball milling for 5 hours;

[0030] (2) Spray-dry the uniformly mixed slurry, feed it under magnetic stirring, the nozzle diameter is 2mm, the inlet temperature is 170°C, the outlet temperature is 100°C, the feed rate is 13ml / min, the compressed air pressure 0.5MPa, compressed air flow rate is 1.5m 3 / h, M 气 / M 液 =6.67;

[0031] (3) Dry the powder obtained by spray drying at 80°C;

[0032] (4) Put the obtained powder in a resistance furnace (atmospheric atmosphere) for heat treatment, the heating rate is 5°C / min, first keep warm at 650°C for 3 hours, remove the organic additives in...

Embodiment 2

[0035] (1) Weigh 94g of deionized water and add it to the ball mill tank, add 10g of ammonium polyacrylate solution (concentration 40%), take 100g of nano-hydroxyapatite and mix it, prepare slurry (solid content 50%), ball mill for 5 hours, add 12g polyethylene glycol, continue ball milling for 5h;

[0036] (2) Spray-dry the uniformly mixed slurry, feed it under magnetic stirring, the nozzle diameter is 2mm, the inlet temperature is 170°C, the outlet temperature is 100°C, the feed rate is 13ml / min, the compressed air pressure 0.5MPa, compressed air flow rate is 1.5m 3 / h, M 气 / M 液 =6.67;

[0037] (3) Dry the powder obtained by spray drying at 80°C;

[0038] (4) Put the obtained powder in a resistance furnace (atmospheric atmosphere) for heat treatment, the heating rate is 5°C / min, first keep warm at 650°C for 3 hours, remove the organic additives in the powder, and continue heating to Keep warm at 950°C high temperature section for 2 hours, then cool to 500°C at a rate of...

Embodiment 3

[0041] (1) Weigh 94g of deionized water and add it to the ball mill tank, add 10g of ammonium polyacrylate solution (concentration 40%), take 100g of nano-hydroxyapatite and mix it, prepare slurry (solid content 40%), ball mill for 5 hours, add 6g polyethylene glycol, continue ball milling for 5h;

[0042] (2) Spray-dry the uniformly mixed slurry, feed it under magnetic stirring, the nozzle diameter is 2mm, the inlet temperature is 170°C, the outlet temperature is 100°C, the feed rate is 13ml / min, the compressed air pressure 0.5MPa, compressed air flow rate is 1.5m 3 / h, M 气 / M 液 =6.67;

[0043] (3) Dry the powder obtained by spray drying at 80°C;

[0044] (4) Put the obtained powder in a resistance furnace (atmospheric atmosphere) for heat treatment, the heating rate is 5°C / min, first keep warm at 650°C for 3 hours, remove the organic additives in the powder, and continue heating to 950°C high-temperature section for 1-2 hours, then cooled to 500°C at a rate of 10°C / min ...

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Abstract

The invention discloses a preparation method of a structure size-controllable hydroxyapatite powder for plasma thermal spraying. Nano hydroxyapatite is selected as the primary powder; the primary powder is mixed with deionized water in which a dispersant ammonium polyacrylate is added to prepare a slurry; next, a certain amount of polyethylene glycol to the slurry and stirred evenly; next, the mixture is spray-dried; and in combination with subsequent thermal treatment, the obtained aggregated sintered hydroxyapatite powder is controllable in particle size and high in crystalline; especially, the prepared hollow powder is adjustable in wall thickness so as to meet different requirements for the sprayed powder structure in practical production; the whole preparation method is simple in process operation and low in cost. The prepared hydroxyapatite powder is applicable to preparation of a surface coating on an artificial implant.

Description

technical field [0001] The invention relates to a method for preparing hydroxyapatite powder which can be used for thermal spraying, in particular to a method for preparing hydroxyapatite powder with controllable particle size distribution and powder structure, and belongs to the field of biological material preparation. Background technique [0002] The structure and composition of hydroxyapatite are similar to the main inorganic parts in human and animal bones and teeth, and it has excellent bioactivity and biocompatibility; currently, it has been used as a bioactive coating for implants and bone defect filling materials. It is widely used in clinical operations such as dentistry, orthopedics, and plastic surgery. [0003] After more than 20 years of development, plasma spraying preparation of hydroxyapatite coating technology has been successfully applied clinically. This technology is currently the only technology designated by the US Food and Drug Administration (FDA) f...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y30/00
Inventor 李辉杨海鑫谷佳宾席晓丽祝弘滨栗卓新魏琪
Owner BEIJING UNIV OF TECH
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