Method for preparing medicament sustained-release material

A drug preparation and sustained-release technology, applied in the field of preparation of biodegradable polymer drug sustained-release materials, can solve the problems of flexible and effective control of drug administration schemes, difficulty in meeting the release requirements of drugs with different solubility properties, and achieve broad industrialization and market Prospects, stable product quality indicators, and the effect of improving phase morphology
CN103735490AActive Publication Date: 2014-04-23SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2014-04-23

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Abstract

The invention discloses a method for preparing a medicament sustained-release composite material. In the method, biodegradable high polymers are taken as a substrate and a dispersed phase, and 50-99 percent by weight of a biodegradable high polymer substrate, 50-1 percent by weight of a biodegradable high polymer dispersed phase, and a medicament of which the amount is 0.01-40 percent based on the total weight of a biodegradable high polymer mixture are fused and mixed by using an extruding machine of a multi-stage bilateral stretching, mixing and pelletizing integrated device, so that structuring of a drug-loading biodegradable high polymer blend is realized, a high polymer drug-loading substrate with flexibly-controllable releasing performance is prepared, and different medicament releasing demands are met. By adopting a continuous production process in the method, the production efficiency is increased, the process is simple, and the quality indexes of different batches of products are stable. The method can be applied to large-scale industrial production, is wide the application range, and has wide industrial and market prospects.
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Description

technical field

[0001] The invention relates to a preparation method of a biodegradable polymer drug sustained-release material, more specifically to a method for preparing a melt blending preparation with adjustable structure, designable performance, continuous production, and flexible and controllable drug release behavior. The invention discloses a method for biodegrading polymer drug slow-release materials, belonging to the technical field of functional composite materials. Background technique

[0002] Drug sustained-release preparations are also called sustained release drug delivery systems. Compared with traditional drug delivery systems, they do not require frequent administration and can maintain effective drug concentrations in the body for a longer period of time, which can greatly increase drug delivery. efficiency and reduce side effects. Drug-loaded materials are generally divided into two types: non-biodegradable materials and biodegradable materials. Among ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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