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Method for preparing medicament sustained-release material

A drug preparation and sustained-release technology, applied in the field of preparation of biodegradable polymer drug sustained-release materials, can solve the problems of flexible and effective control of drug administration schemes, difficulty in meeting the release requirements of drugs with different solubility properties, and achieve broad industrialization and market Prospects, stable product quality indicators, and the effect of improving phase morphology

Active Publication Date: 2014-04-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above studies can overcome the problems such as the difficulty of solvent removal caused by the preparation of drug-loaded materials by the solution method, most of them are homogeneous systems, and it is difficult to flexibly and effectively control the dosing regimen, and it is difficult to meet the release requirements of drugs with different solubility properties.

Method used

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  • Method for preparing medicament sustained-release material
  • Method for preparing medicament sustained-release material
  • Method for preparing medicament sustained-release material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060]A polycaprolactone (matrix) / polyethylene oxide (disperse phase) drug sustained-release composite material comprises the following components and contents in parts by weight:

[0061]

[0062] Explanation: the weight of cephalexin (being a drug) is 1% of the total weight of the biodegradable polymer matrix and the dispersed phase.

[0063] The first step, at first prepare raw materials by above-mentioned components;

[0064] In the second step, the drug is dried in a vacuum oven at 60°C for 6 hours;

[0065] In the third step, the dried cephalexin, polycaprolactone and polyethylene oxide obtained in the second step are placed in a high mixer and premixed for 5 minutes at a speed of 100 rpm to obtain a drug and polymer premix , and dry the premixed composite particles in a vacuum oven at 50 °C for 3 hours.

[0066] In the fourth step, the drug and the polymer premix obtained in the third step are put into figure 1 The single-screw extruder 1 of the integrated biaxia...

Embodiment 2

[0071] A polylactic acid (matrix) / polyethylene oxide (dispersed phase) drug sustained-release composite material comprises the following components and their contents in parts by weight:

[0072]

[0073] Explanation: the weight of diclofenac sodium (being a medicine) is 5% of the total weight of the biodegradable polymer matrix and the dispersed phase.

[0074] The first step, at first prepare raw materials by above-mentioned components;

[0075] In the second step, the drug is dried in a vacuum oven at 60°C for 6 hours;

[0076] In the third step, the dried diclofenac sodium, polylactic acid and polyethylene oxide obtained in the second step are premixed together in a high-speed mixer for 5 minutes at a speed of 100 rpm to obtain a drug and polymer premix. Then put the obtained drug and polymer premix into a twin-screw extruder for melt blending, extrusion, and granulation to obtain premixed composite granules of polylactic acid / polyethylene oxide / diclofenac sodium, and ...

Embodiment 3

[0081] A polycaprolactone-polylactic acid (matrix) / polyethylene oxide (dispersed phase) drug sustained-release composite material comprises the following components and contents in parts by weight:

[0082]

[0083] Explanation: the weight of ibuprofen cephalexin (being medicine) is 20% of the total weight of the biodegradable polymer matrix 1-2 and the dispersed phase.

[0084] The first step, at first prepare raw materials by above-mentioned components;

[0085] In the second step, the drug is dried in a vacuum oven at 60°C for 6 hours;

[0086] In the third step, the dried ibuprofen, polycaprolactone, and polylactic acid obtained in the second step are put into a twin-screw extruder for melt blending, extrusion, and granulation to obtain premixed granules of medicine and polymer. The mixed composite particles were dried in a vacuum oven at 50 °C for 3 hours, and the temperatures of the feeding port, conveying section, melting section, homogenizing section and die of the...

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Abstract

The invention discloses a method for preparing a medicament sustained-release composite material. In the method, biodegradable high polymers are taken as a substrate and a dispersed phase, and 50-99 percent by weight of a biodegradable high polymer substrate, 50-1 percent by weight of a biodegradable high polymer dispersed phase, and a medicament of which the amount is 0.01-40 percent based on the total weight of a biodegradable high polymer mixture are fused and mixed by using an extruding machine of a multi-stage bilateral stretching, mixing and pelletizing integrated device, so that structuring of a drug-loading biodegradable high polymer blend is realized, a high polymer drug-loading substrate with flexibly-controllable releasing performance is prepared, and different medicament releasing demands are met. By adopting a continuous production process in the method, the production efficiency is increased, the process is simple, and the quality indexes of different batches of products are stable. The method can be applied to large-scale industrial production, is wide the application range, and has wide industrial and market prospects.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable polymer drug sustained-release material, more specifically to a method for preparing a melt blending preparation with adjustable structure, designable performance, continuous production, and flexible and controllable drug release behavior. The invention discloses a method for biodegrading polymer drug slow-release materials, belonging to the technical field of functional composite materials. Background technique [0002] Drug sustained-release preparations are also called sustained release drug delivery systems. Compared with traditional drug delivery systems, they do not require frequent administration and can maintain effective drug concentrations in the body for a longer period of time, which can greatly increase drug delivery. efficiency and reduce side effects. Drug-loaded materials are generally divided into two types: non-biodegradable materials and biodegradable materials. Among ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K45/00A61K47/34A61K47/36A61K47/32B29C47/58B29C47/92B29C48/50B29C48/525B29C48/92
CPCB29C47/38B29C47/6012B29B7/46B29B7/72B29B7/7461B29B9/06B29B9/12B29C48/397B29C48/92B29C2948/92704B29C48/395B29C48/625B29C2948/92828B29C48/525
Inventor 郭少云陈蓉张聪
Owner SICHUAN UNIV
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