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Cefixime chewable tablet and preparation method thereof

A technology for cefixime and chewable tablets, which is applied to the field of cefixime chewable tablets and its preparation, can solve the problems of limited use of tablets, low bioavailability, low physical strength, etc., and achieves elimination of specific odor and bioavailability. High, curative effect

Active Publication Date: 2014-04-23
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN1803138A discloses a cefixime oral disintegrating agent and its preparation method. Orally disintegrating tablets generally have the problems of low physical strength, friability, and inconvenient transportation and storage.
[0006] Chinese patent CN101401810A discloses a dispersible tablet of cefixime and its preparation method. Because the tablet is pressurized and formed, it disintegrates slowly, has low bioavailability, and is difficult for some patients to swallow. Therefore, the use of the tablet is may be limited in some way

Method used

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  • Cefixime chewable tablet and preparation method thereof
  • Cefixime chewable tablet and preparation method thereof
  • Cefixime chewable tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Prescription: 10000 tablets

[0038] Cefixime Anhydrous 1000g Mannitol 1600g

[0039] Microcrystalline cellulose 150g Pregelatinized starch 70g

[0040] Sweet orange flavor 10g Magnesium stearate 50g

[0041] Preparation:

[0042] (1) Cefixime passes through a 100-mesh sieve, and the auxiliary materials pass through a 80-mesh sieve respectively, and set aside;

[0043] (2) Mix the prescribed amount of cefixime anhydrate, mannitol, microcrystalline cellulose, pregelatinized starch, and sweet orange flavor in a mixer;

[0044] (3) Add magnesium stearate to step (2) and mix for 25 minutes. Set the tableting environment temperature to 25°C and the humidity to 60% to press the tablet. The tableting pressure is controlled at 40KN, and the speed is 12,000 tablets per hour. Tablets to prepare cefixime chewable tablets.

Embodiment 2

[0046] Prescription: 10000 tablets

[0047] Cefixime Anhydrous 1100g Mannitol 1500g

[0048] Microcrystalline cellulose 120g Pregelatinized starch 60g

[0049] Sweet orange flavor 15g Magnesium stearate 60g

[0050] Preparation:

[0051] (1) Cefixime passes through a 100-mesh sieve, and the auxiliary materials pass through a 80-mesh sieve respectively, and set aside;

[0052] (2) Mix the prescribed amount of cefixime anhydrate, mannitol, microcrystalline cellulose, pregelatinized starch, and sweet orange flavor in a mixer;

[0053] (3) Add magnesium stearate to step (2) and mix for 25 minutes. Set the tabletting environment temperature at 25°C and the humidity at 55% to press the tablet. The tableting pressure is controlled at 35KN, and the speed is 12,500 tablets per hour. Tablets were prepared to prepare cefixime chewable tablets.

Embodiment 3

[0055] Prescription: 10000 tablets

[0056]Cefixime Anhydrous 1200g Mannitol 1700g

[0057] Microcrystalline cellulose 170g Pregelatinized starch 80g

[0058] Sweet orange flavor 20g Magnesium stearate 70g

[0059] Preparation:

[0060] (1) Cefixime passes through a 100-mesh sieve, and the auxiliary materials pass through a 80-mesh sieve respectively, and set aside;

[0061] (2) Mix the prescribed amount of cefixime anhydrate, mannitol, microcrystalline cellulose, pregelatinized starch, and sweet orange flavor in a mixer;

[0062] (3) Add magnesium stearate to step (2) and mix for 30 minutes, set the tableting environment temperature to 30°C, and press the tablet under the conditions of humidity 65%, the tableting pressure is controlled at 45KN, and the speed is 13,000 tablets per hour. Tablets were prepared to prepare cefixime chewable tablets.

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Abstract

The invention discloses a cefixime chewable tablet and a preparation method thereof. The method comprises the following steps: (1) screening cefixime through a 100-mesh screen, and respectively screening mannitol, a disintegrating agent, an adhesive, orange flavor and a lubricant for later use; (2) adding the cefixime, a sweetening agent, a disintegrating agent, an adhesive and a flavoring agent into a mixer, and uniformly mixing to obtain medicinal powder; and (3) adding magnesium stearate into the medicinal powder obtained in the step (2), uniformly mixing, and preparing the cefixime chewable tablet by adopting a method of directly tabletting powder. The cefixime chewable tablet disclosed by the method is good in taste and stable in quality, and the effective components of the medicine can be quickly absorbed through mouth mucosa by virtue of chewing. The cefixime chewable tablet is quick in absorption, high in bioavailability and remarkable in curative effect, and can solve the problems in the prior art.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a cefixime chewable tablet and a preparation method thereof. Background technique [0002] Cefixime (Cefixime) is the third-generation cephalosporin product developed by Fujisawa Pharmaceutical Co., Ltd. in Japan. It was launched in Japan in 1987. In 1998, among the five developed countries in Europe, cefixime surpassed cefuroxime axetil and cefaclor to become the oral cephalosporin with the highest market share. In 1999, more than 80 countries in the world had used cefixime clinically. [0003] my country began to import cefixime raw materials and preparations in 1994. The administrative protection of cefixime raw materials in China expired in early 2001, and because of its obvious clinical effect, definite curative effect and few side effects, its market demand has been on a fast-growing channel in recent years. Clinical verification shows that cefixime...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/546A61P31/04A61J3/00
Inventor 刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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