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A pharmaceutical composition for preventing and treating osteoporosis and its preparation method

A technology for osteoporosis and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of low quality control standards, low content of active ingredients, and single effect, and achieve the goal of raw material medicine The effect of wide distribution of resources, clear active ingredients, and low toxic and side effects

Active Publication Date: 2016-02-24
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It is worth noting that the traditional Chinese medicine decoction is troublesome to decoct, the decoction is large in volume, bitter in taste, inconvenient to take and carry; and it is easy to mold and ferment, so it is not suitable for long-term storage and large-scale preparation
Traditional Chinese patent medicines such as Shengu Powder, Gusongkang Mixture, Guyuling Capsules, Liuwei Zhuanggu Granules, etc. Some of these dosage forms are inconvenient to carry or take, and some have more medicinal flavors, less active ingredients, and low quality control standards. Difficult to achieve satisfactory curative effect in clinical treatment
The active ingredients of modern traditional Chinese medicine, such as total saponins of Dipsacus, total flavonoids of Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome, total flavonoids of Epimedium, etc., although the curative effect is accurate and the quality is controllable, but the effect is single, which fails to reflect the concept of overall regulation in traditional Chinese medicine.

Method used

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  • A pharmaceutical composition for preventing and treating osteoporosis and its preparation method
  • A pharmaceutical composition for preventing and treating osteoporosis and its preparation method
  • A pharmaceutical composition for preventing and treating osteoporosis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1, the preparation of Epimedium and Ligustrum lucidum extract and the preparation of pharmaceutical composition

[0053] 1. Prepare Epimedium and Ligustrum lucidum extracts by decocting:

[0054] (1) Preparation of Epimedium extract: Take 8000g of Epimedium, chop it, and use 90% ethanol aqueous solution as the extraction solvent to extract 3 times, the first time is 1g Epimedium: 15mL extraction solvent The extraction was carried out at a ratio of 70°C for 3 hours; the second and third times were extracted by mixing the medicinal residues obtained in the previous time with the extraction solvent (the ratio was 1g medicinal residues: 10mL extraction solvent) for extraction at 70°C for 2 hours. Combine the extracts, remove the ethanol in the extract, then extract the extract with petroleum ether for 3 times (to remove chlorophyll), discard the petroleum ether phase, and collect the water phase; D-101 macroporous adsorption resin on the water phase, wash with wa...

Embodiment 2

[0058] Example 2, the effect of the active ingredient extract of Epimedium Ligustrum lucidum on retinoic acid-induced osteoporosis in rats

[0059] 1. Sixty 3-month-old male Wistar rats were randomly divided into 6 groups, namely, the normal control group, the model control group, the epimedium privet decoction control group (abbreviation: water decoction group), epimedium Low, medium and high dose groups of the extract of Huo Ligumi (respectively referred to as low, medium and high dose groups), 10 rats in each group.

[0060] Except for the normal control group, rats in other groups were treated with retinoic acid suspension (preparation method: first prepare 0.5% (0.5g / 100mL) carboxymethylcellulose sodium (CMC-Na) solution with distilled water, and then prepare 7mg·mL -1 retinoic acid suspension) by 10mL·kg -1 The normal control group was given intragastric administration with an equal volume of 0.5% CMC-Na, and the model was established continuously for 2 weeks. At the ...

experiment example 3

[0111] Experimental example 3, the effect of the active ingredient extract of Epimedium Ligustrum lucidum on the rat model of glucocorticoid-induced osteoporosis

[0112] Clean-grade healthy SD rats, half male and half male, weighing (200±20) g, were divided into 6 groups according to the random number table method, the same as in Experimental Example 2. Except for the normal control group, rats in other groups were given alternate intramuscular injections of dexamethasone 1 mg·kg into the inner thighs. -1 Body weight, 2 times a week, a total of 8 weeks, normal control group rats were given an equal volume of normal saline. At the same time of modeling, the animals in each group were intragastrically administered with corresponding drugs or normal saline, once a day, for a total of 8 weeks. Dosage, execution, sampling, and statistical methods for experimental results are the same as in Experimental Example 2.

[0113] 1. Comparison of bone mineral density in each group of ra...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating osteoporosis and a preparation method thereof. The pharmaceutical composition is prepared from epimedium extract and glossy privet fruit extract. The pharmaceutical composition has the advantages that (1) the traditional Chinese medicinal extract composition selects epimedium and glossy privet fruit extract for mild tonifying kidney and balancing yin and yang as study objects regarding the characteristics of OP (osteoporosis) pathogenesis, namely deficiency in kidney-essence and deficiency of yin and yang, so that basis is provided to development of a novel anti-osteoporosis medicine of effective components of epimedium and glossy privet fruit capable of mild tonifying yin and yang; (2) the bulk drug for the traditional Chinese medicinal composition preparation is wide in resource distribution and low in toxic and side effect, and can be taken for a long time; (3) the traditional Chinese medicinal composition is concise in prescription, definite in effective component, exact in curative effect and controllable in quality, does not need the traditional Chinese medicine decocting process, and is convenient to take.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating osteoporosis and a preparation method thereof. Background technique [0002] Osteoporosis (OP) is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone tissue fibrous structure, which in turn causes bone fragility and increased risk of fracture. 7 digits. With the prolongation of life expectancy and the aging of society in our country, the incidence of OP has also increased significantly, and it has become an important public health problem affecting our society. According to the statistics of some provinces and cities in my country, the incidence rate of OP in the elderly over 60 years old is about 59.89%. The annual incidence of fracture due to OP is about 9.6%, and it tends to increase year by year, which brings serious burden to the society and family. Therefore, it is of great significance to screen and develop anti-OP drugs. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/638A61P19/10
Inventor 刘仁慧王秀娟许利平康学
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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