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Preparation method of selenized sulfated chitosan and application of selenized sulfated chitosan to livestock feed

A technology of selenized chitosan sulfate and chitosan sulfate, which is applied to the preparation of water-soluble selenized chitosan sulfate and the application field of livestock and poultry feed, and can solve the problem of complicated preparation, long time and large pollution And other problems, to achieve a wide range of application prospects, simple steps, and improve the effect of growth performance

Inactive Publication Date: 2014-05-07
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is cumbersome to prepare, takes a long time, uses corrosive liquids such as sulfuric acid, and causes large pollution

Method used

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  • Preparation method of selenized sulfated chitosan and application of selenized sulfated chitosan to livestock feed
  • Preparation method of selenized sulfated chitosan and application of selenized sulfated chitosan to livestock feed
  • Preparation method of selenized sulfated chitosan and application of selenized sulfated chitosan to livestock feed

Examples

Experimental program
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Effect test

Embodiment 1

[0033] 1. Add 50ml of dimethylformamide to a three-neck flask with a stirring device, add 10ml of chlorosulfonic acid dropwise in an ice bath, and stir at room temperature for 30min after the dropwise addition to obtain a sulfonated reagent;

[0034] 2. Mix 3.5ml of dichloroacetic acid and 50ml of formamide, add 3g of chitosan and stir for 1 hour to obtain a chitosan solution;

[0035] 3. Weigh 2.190g of sodium selenite and dissolve it in distilled water, set the volume to 1L, containing 1g·L-1 of selenium, and obtain the selenium standard stock solution;

[0036] 4. Synthesis of chitosan sulfate: According to the reaction system of 3.0g chitosan and 60ml sulfonating reagent, mix evenly, react for 1h at 60°C, 100r min-1, the reactant turns brown, pour into 5 times In water and ethanol, place it at 20°C for 2 hours to form a crude chitosan sulfate; the precipitate is vacuum filtered, washed twice with ethanol, and then dried at 60°C; the yield of the prepared chitosan sulfate i...

Embodiment 2

[0039] 1. Add 100ml of dimethylformamide to a three-neck flask with a stirring device, add 30ml of chlorosulfonic acid dropwise in an ice bath, and stir at room temperature for 30min after the addition is complete to obtain a sulfonation reagent;

[0040] 2. Mix 3.5ml of dichloroacetic acid and 50ml of formamide, add 3g of chitosan and stir for 2 hours to obtain a chitosan solution;

[0041] 3. Weigh 2.190g of sodium selenite and dissolve it in distilled water, set the volume to 1L, containing 1g·L-1 of selenium, and obtain the selenium standard stock solution;

[0042] 4. Synthesis of chitosan sulfate: Mix 3.0g of chitosan and 60ml of sulfonating reagent evenly in the reaction system, react at 60°C, 100r min-1 for 1h, the reactant turns brown, pour 5 times In absolute ethanol, place at 20°C for 2 hours to form a crude chitosan sulfate; the precipitate is vacuum filtered, washed twice with ethanol, and the product is dried at 60°C; the yield of the prepared chitosan sulfate is...

Embodiment 3

[0049] 1. Add 100ml of dimethylformamide to a three-neck flask with a stirring device, add 30ml of chlorosulfonic acid dropwise in an ice bath, and stir at room temperature for 30min after the addition is complete to obtain a sulfonation reagent;

[0050] 2. Mix 3.5ml of dichloroacetic acid and 50ml of formamide, add 3g of chitosan and stir for 1 hour to obtain a chitosan solution;

[0051] 3. Weigh 2.190g of sodium selenite and dissolve it in distilled water, set the volume to 1L, containing 1g·L-1 of selenium, and obtain the selenium standard stock solution;

[0052] 4. Synthesis of chitosan sulfate: Mix 3.0g of chitosan and 60ml of sulfonating reagent evenly in the reaction system, react at 60°C, 120r min-1 for 2h, the reactant turns brown, pour 5 times In absolute ethanol, place at 20°C for 2 hours to form a crude chitosan sulfate; the precipitate is suction-filtered, washed twice with ethanol, and the product is dried at 60°C; the yield of the prepared chitosan sulfate is...

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Abstract

The invention discloses a method for rapidly producing water-soluble selenized sulfated chitosan. The method comprises the following steps: mixing a chitosan solution and a sulfonating reagent to synthesize sulfated chitosan; uniformly mixing the sulfated chitosan and a selenium standard stock solution in a certain ratio; stirring for reacting at 10-60 DEG C for 0.5-4 hours; precipitating and washing by using 95 percent ethanol; drying at a low temperature to obtain the light yellow selenized sulfated chitosan. The obtained product is water-soluble, high in selenium content and sulfate content and stable in property, can be used for enhancing the growing functions, liver functions and anti-oxidation functions of chickens, has a high biological function in chickens, and has a wide application prospect in the breeding industry as a livestock feed additive.

Description

Technical field [0001] The invention belongs to the technical field of selenized polysaccharide sulfate, and relates to a preparation method of water-soluble selenized chitosan sulfate and its application in livestock and poultry feed. Background technique [0002] Chitosan (chitosan, CTS) is the product of chitin (chitin) after deacetylation treatment, that is, deacetylated chitin, scientific name polyglucosamine, has been called by many scientists to remove protein, fat, sugar, vitamin , the sixth vital element necessary for the human body besides minerals, has the functions of enhancing immunity, anti-aging, anti-oxidation, anti-cancer, anti-rheumatism and preventing AIDS. As the most abundant natural nitrogen-containing organic compound and the second largest organic natural resource in nature, chitosan has physiological adaptability, complete decomposability, multifunctional reactivity, three-dimensional structure and chirality, and can be regenerated The research and ...

Claims

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Application Information

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IPC IPC(8): C08B37/08A23K1/16A61K31/737A61P3/02A61P1/16A61P39/06
Inventor 陈甫朱连勤
Owner QINGDAO AGRI UNIV
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