Houttuybein Sodium Vaginal Expansion Suppository and Its Preparation Method and Detection Method

Abstract

The present invention relates to a houttuyfonate sodium vaginal expansive suppository and a preparation method and a detection method thereof. The expansive suppository comprises a drug-containing matrix containing houttuyfonate sodium and an expansion carrier; acid particles and alkaline particles in the drug-containing matrix When meeting with water, carbon dioxide is produced, which then foams. In addition to the expansion of the expansion carrier, the main drug can reach the deep vagina and folds, improving the scope of action of the drug; the ascorbic acid in the acidic particles also has an antioxidant effect, increasing the stability of the suppository; The buffer salt particles in the drug-containing matrix provide a suitable pH environment for the vagina, which is conducive to the sufficient effervescence of the suppository and improves the bioavailability of houttuyfonate sodium in the suppository; the hollow effervescent expansible vaginal suppository will It is sealed in the matrix cavity, which improves the stability of the expansion plug; and the Houttuyfonate Sodium vaginal expansion suppository provided by the present invention adopts six original leading technologies, which can prevent the outflow of medicinal liquid, high stability, and long-lasting curative effect , prevent secondary infection and other beneficial effects.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a houttuyfonate sodium vaginal expansive suppository, a preparation method and a detection method thereof. Background technique [0002] Houttuyfonate sodium is a white or off-white needle-like or scale-like crystal, or crystalline powder; it has a slight odor and has a special fishy smell when it meets water; it is easily soluble in hot water and slightly soluble in water or ethanol. Soluble, almost insoluble in chloroform or benzene. Houttuyfotin sodium has obvious inhibitory effect on catarrhal bacteria, influenza bacillus, pneumococcus, and staphylococcus aureus, and has obvious effects of antagonizing inflammatory exudation and tissue edema in the early stage of inflammation, and inhibiting inflammatory pain response, especially for Treatment of cervical erosion. Because its structure is the adduct of dicarbonyl and aldehyde carbonyl and sodium bisulfite, it is relativ...

AI Technical Summary

Problems solved by technology

Because its structure is the adduct of dicarbonyl and aldehyde carbonyl and sodium bisulfite, it is relatively unstable. When it is affected by heat, light, humidity, etc., especially alkaline solution, it is easy to decompose into impurity compounds such as carbonyl and carboxyl. its curative effect

Existing houttuyfonate sodium suppositories have technical problems such as low dissolution rate, small area of ​​drug action, poor stability, and slow onset of action; common houttuyfonate sodium suppositories also have the disadvantages of being difficult to clean and easily polluting clothes; active ingredients and The human body contact surface is small, resulting in insufficient absorption, and technical problems such as not exerting the best curative effect of the formula

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