Bone repair regeneration material and preparation method thereof
A technology for bone repair and composite scaffolds, applied in medical science, prosthesis, etc., can solve the problems of loss of mechanical support, low molecular weight, and decreased mechanical properties of composite materials with hydroxyapatite content, and achieves adjustable pore size and porosity. The effect of uniform distribution of components and excellent biological function
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[0044] The preparation method of the above-mentioned bone repair and regeneration material of the present invention includes the following 5 steps:
[0045] (1) Preparation of calcium phosphate salt composition
[0046] The powder of the calcium phosphate salt composition is prepared, wherein the content of hydroxyapatite is 50-70wt%, and the content of β-tricalcium phosphate is 30-50wt%; preferably, the powder of the calcium phosphate salt composition It is prepared by in-situ mixing method, including the following steps:
[0047] (1.1) Weigh the calculated amount of calcium nitrate Ca(NO) according to the Ca / P molar ratio of 1.5-1.67 3 ) 2 And trimethyl phosphate (CH 3 O) 3 PO, respectively dissolved in distilled water and ethanol;
[0048] (1.2) Add citric acid C in an equimolar amount with calcium ions in the calcium nitrate aqueous solution 6 H 8 O 7 ; After being fully dissolved, mix the calcium nitrate aqueous solution and the trimethyl phosphate alcohol solution, adjust the pH...
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[0065] Example 1
[0066] The bone repair and regeneration material of the present invention is prepared by the following method:
[0067] (1) Preparation of calcium phosphate salt composition
[0068] (1.1) Weigh out 13.702g (0.0835mol) calcium nitrate and 7.05g (0.05mol) trimethyl phosphate according to the Ca / P molar ratio of 1.67, and dissolve them in 80ml distilled water and 30ml ethanol respectively;
[0069] (1.2) Add 16.032g of citric acid equimolar to the calcium ion in the calcium nitrate aqueous solution. After fully dissolving, mix the calcium nitrate aqueous solution and the ethanol solution of trimethyl phosphate, and adjust the pH of the mixture to 7.5 with ammonia , Aging at room temperature for 48 hours; then, drying at 190°C for 2 hours to form a dry gel;
[0070] (1.3) The dry gel obtained in step (1.2) is calcined at 500°C for 1 hour to obtain the required nanometer powder of the calcium phosphate composition, wherein the mass percentage of hydroxyapatite is 70%, β ...
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[0083] Example 2
[0084] The bone repair and regeneration material of the present invention is prepared by the following method:
[0085] (1) Preparation of calcium phosphate salt composition
[0086] (1.1) Weigh 12.307g (0.075mol) calcium nitrate and 7.05g (0.05mol) trimethyl phosphate according to the Ca / P molar ratio of 1.5, and dissolve them in 80ml distilled water and 30ml ethanol respectively;
[0087] (1.2) Add 14.400g of citric acid equimolar to the calcium ions in the calcium nitrate aqueous solution. After fully dissolving, mix the calcium nitrate aqueous solution and the trimethyl phosphate alcohol solution, and adjust the pH of the mixture to 11 with ammonia. Aging for 48 hours at room temperature; then, drying at 150°C for 3 hours to form a dry gel;
[0088] (1.3) The dry gel obtained in step (1.2) is calcined at 600°C for 2 hours to obtain the required nanometer powder of calcium phosphate composition, wherein the mass percentage of hydroxyapatite is 50%, β -The mass pe...
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