DNA hydrogel and application thereof in detection of peroxide

A technology of peroxides and hydrogels, which is used in analysis by chemical reaction of materials, material analysis by observing the effect on chemical indicators, determination/inspection of microorganisms, etc.
CN103804590AInactive Publication Date: 2014-05-21SHENYANG PHARMA UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2014-05-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of pharmaceutical analysis, relates to DNA hydrogel and an application of the DNA hydrogel in detection of a peroxide, and in particular relates to an application of high polymer material DNA hydrogel in peroxide detection by naked eyes. The hydrogel uses DNAzyme with peroxidase activity as a cross-linking agent and adopts polyacrylamide as a skeleton. The DNA hydrogel is formed by DNA-containing polyacrylamide macromolecules, T-DNAzyme-T and heme through intermolecular force. The hydrogel is in a gel state and can be used for peroxide detection by naked eyes. The DNA hydrogel has the advantages of having simplicity in operation and capability of semi-quantitative detection by naked eyes and reusability of the material and the like.
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Description

Technical field:

[0001] The invention belongs to the technical field of drug analysis, relates to a DNA hydrogel and its application in the detection of hydrogen peroxide, and in particular to the application of the macromolecular material DNA hydrogel in the detection of peroxide with naked eyes. Background technique:

[0002] DNA hydrogels are divided into pure DNA hydrogels and DNA hydrogels hybridized with artificial polymers. The present invention only concerns the latter. The latter is a functional smart hydrogel that embeds DNA in polymer hydrogel and has the characteristics of both hydrogel and DNA.

[0003] DNase (hereinafter referred to as DNAzyme) is a DNA molecule with catalytic activity, which has been widely studied in the fields of pharmacy, biology and materials science. The present invention relates to DNAzymes that mimic peroxidase activity. The oligonucleotide chains of this DNAzyme can be self-folded or intermolecularly combined in the form of tetrame...

Claims

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