A kind of visible light catalyzed cross-coupling method to prepare coupling product and release hydrogen

Abstract

The invention discloses a method using visible light catalyzed cross-coupling reaction to prepare a coupling product and release hydrogen. The method is as follows: a tertiary amine, a nucleophile, a cobalt complexe 1 or a cobalt complexe 2 and eosin Y are added into a solvent to obtain a mixed solution, and under the protection of an inert gas, visible light is used to irradiate the mixed solution to obtain the cross-coupling product of the tertiary amine and the nucleophile and release the hydrogen. The reaction can be achieved by visible light irradiation in the presence of the inert gas, and is mild in reaction conditions, the whole system is free of externally-applied electron donors or acceptors, and the method is energy-saving and environmentally-friendly.

Description

technical field

[0001] The invention belongs to the technical field of catalytic synthesis and relates to a method for cross-coupling dehydrogenation, in particular to a method for cross-coupling dehydrogenation of tertiary amines and nucleophilic reagents catalyzed by visible light. Background technique

[0002] In the field of chemistry, the development of reactions with high selectivity, mild conditions, and environmental protection has always been the goal pursued by chemists. In traditional chemistry, relatively harsh conditions are often required, such as high temperature, high pressure, strong acid, strong alkali, etc. As early as a century ago, the famous photochemist Ciamician wrote an article describing and prospecting the advantages and importance of light as a clean energy source in driving chemical reactions. Since 2008, visible light-catalyzed organic reactions have achieved a series of remarkable research results. For example, the Yoon group at the Universit...

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