Glucose iodine derivative, preparation method thereof and application thereof in pharmacy

Abstract

The invention provides a 3, 4, 6-substituted-D-glucose iodine derivative and a preparation method and application thereof. A drug is prepared from the 3, 4, 6-substituted-D-glucose iodine derivative as an active component and a medicinal auxiliary material. Bactericidal tests of the 3, 4, 6-substituted-D-glucose iodine derivative on pseudomonas aeruginosa, staphylococcus aureus and escherichia coli are performed, and results show that the 3, 4, 6-substituted-D-glucose iodine derivative has bactericidal effects on the staphylococcus aureus, pseudomonas aeruginosa and escherichia coli. Antiviral tests of a 3, 4, 6-triacetyl-D-glucose iodine preparation are performed, results show that the 3, 4, 6-triacetyl-D-glucose iodine preparation has a direct inactivation effect on EV71 (Human enterovirus 71) virus, and the therapeutic index is 5.5 times of that of contrast drug ribavirin injection. Therefore, the 3, 4, 6-substituted-D-glucose iodine derivative can be used for the preparation of antibacterial and antiviral drugs, especially can be used for the preparation of drugs for treatment of hand foot and mouth disease, provides a new drug for the treatment of the hand foot and mouth disease, and has a good prospect of clinical application. The present invention provides a preparation method.

Description

technical field

[0001] The invention relates to a pharmaceutical preparation, in particular to a sugar iodide, in particular to a 3,4,6-triacetyl-D-glucose iodine derivative, a preparation method thereof and an application in pharmacy. Background technique

[0002] Hand foot and mouth disease (HFMD) is an infectious disease in children, also known as exanthematous vesicular stomatitis, which mostly occurs in children under 5 years old and can cause herpes on hands, feet, mouth and other parts. The disease is the main clinical symptom with the formation of ulcers after herpes or ulceration of the hands, feet and oral mucosa. There are more than 20 types of enteroviruses that cause HFMD, among which enterovirus 71 (EV 71) is the most common.

[0003] At present, the preparations with iodine as the active ingredient are mostly used for antibacterial, such as iodine tincture, iodophor, povidone iodine, complex iodine, double-chain quaternary ammonium salt complex iodine solutio...

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