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Biodegradable hemostatic membrane

A kind of hemostatic film, biological technology, applied in absorbent pads, medical science, bandages, etc., to achieve excellent hemostasis, wide application range, and little pollution

Active Publication Date: 2014-07-16
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the long preparation time and animal origin in the above hemostatic film preparation technology, the obtained cross-linked film has poor hemostatic effect, fast or slow degradation speed, texture It is relatively hard and brittle, and cannot better meet the clinical requirements. The present invention provides a preparation method of a bioabsorbable hemostatic membrane with short cross-linking time, good hemostatic effect, moderate degradation rate, uniform and soft texture and certain mechanical strength.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In order to investigate the effect of cellulose on the efficacy of the hemostatic film, in this example, hyaluronic acid / sodium carboxymethyl cellulose, hyaluronic acid / sodium hydroxyethyl cellulose and pure hyaluronic acid were prepared respectively as the main components. the hemostatic film, and compare the differences among the three.

[0036] (1) Use NaOH to adjust the pH of deionized water to 10~12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution;

[0037] (2) Three groups of gels were prepared: No. 1, 1000 kD sodium hyaluronate and 500 kD sodium carboxymethyl cellulose were dissolved in the mixed solution, and the mass ratio of sodium hyaluronate to sodium carboxymethyl cellulose was 4 : 1. Mix evenly and fully dissolve the biological polysaccharide to prepare gel I with both sodium hyaluronate and sodium carboxymethyl cellulose concentration of 10%. The amount of 1,4-butanediol diglycidyl ether added accounts for the 1.25% of the to...

Embodiment 2

[0044] (1) Use NaOH to adjust the pH of deionized water to 10~12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution;

[0045] (2) Three groups of gels were prepared, the mass ratio of sodium hyaluronate and sodium carboxymethylcellulose was 2:1, and the mass ratio of sodium hyaluronate and sodium alginate was 1:0.1; The amount of 4-butanediol diglycidyl ether added is 1.25% of the total weight of sodium hyaluronate and sodium carboxymethyl cellulose: No. 1 Dissolve 1500 kD sodium hyaluronate and 500 kD sodium carboxymethyl cellulose In the mixed solution, mix evenly and fully dissolve the biological polysaccharide to prepare gel I with a sodium hyaluronate concentration of 10% and a sodium carboxymethyl cellulose concentration of 5%. Gel II with 1500 kD 1% sodium alginate and cross-linking agent dissolved, the amount of 1,4-butanediol diglycidyl ether in gel II is half of that in gel I, and the pH is adjusted to 3 ~5, 35℃ for 8 h, purified and freez...

Embodiment 3

[0052] In this example, the influence of different molecular weight hyaluronic acid on its physicochemical properties and hemostatic application effect in the preparation of hemostatic film was investigated.

[0053] (1) Use 0.25 N NaOH to adjust the pH of deionized water to 10~12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution;

[0054] (2) Dissolve sodium hyaluronate and sodium carboxymethyl cellulose with molecular weights of 500 kD, 1000 kD, 1500 kD, 2000 kD and 500 kD in the mixed solution, respectively. The mass ratio is 2:1, 1,4-butanediol diglycidyl ether accounts for 1.25% of the total weight of sodium hyaluronate and sodium carboxymethyl cellulose, mix well and fully dissolve the biological polysaccharide to prepare sodium hyaluronate Gel I with a concentration of 10% was subjected to alkaline crosslinking at 35 °C for 4 h;

[0055] (3) Add 500 kD sodium alginate into deionized water mixed with 1,4-butanediol diglycidyl ether, mix well ...

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Abstract

The invention relates to the technical fields of surgical hemostasis and chronic heal wound hemostasis and wound protection, and in particular relates to a biodegradable hemostatic membrane. Alkaline crosslinking is carried out on sodium hyaluronate, a cellulose derivative and a cross-linking agent to obtain gel I; sodium alginate or sodium hyaluronate and 1,4-Butanediol diglycidyl ether are mixed to obtain gel II; the gel I and the gel II are mixed and cross-linked, and then purified and dried, and subjected to film formation under pressure to obtain the biodegradable hemostatic membrane. The obtained membrane is loose in structure and high in safety, easily attaches to and disperses on the surface of a wound, quick to stop bleeding, good in biocompatibility, suitably adjustable in in-vivo degradation time, wide in application range, low in cost, short in process period, little in pollution, low in energy consumption and easy for realizing industrialization, and has the good functions of stopping bleeding, promoting healing and preventing inflammation.

Description

technical field [0001] The invention relates to the technical field of surgical hemostasis and chronic healing wound hemostasis and wound protection, in particular to a bioabsorbable hemostatic membrane. Background technique [0002] Extensive bleeding and oozing are common problems in surgery and trauma surgery, especially for solid organs with multiple vessels. Trauma is often accompanied by coagulation dysfunction caused by massive blood loss. Commonly used traditional methods of hemostasis, such as direct compression and ligation, are difficult to be effective, and effective hemostatic materials are needed to achieve the hemostatic effect. At present, the main absorbable hemostatic materials at home and abroad include fibrin glue, gelatin sponge, oxidized cellulose, microfibrous collagen, chitosan and calcium alginate fiber. [0003] The material used as an ideal hemostatic dressing or hemostatic agent should have good hemostatic performance, excellent biocompatibilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/64
Inventor 刘建建郭学平冯晓毅杨莹莹张燕李超耿凤
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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