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A bioabsorbable hemostatic membrane

A hemostatic film, biological technology, applied in the direction of absorbent pads, medical science, bandages, etc., can solve the problems of poor hemostatic effect, slow degradation speed, and long preparation time of cross-linked films, and achieve excellent hemostasis, promote healing, and short process cycle Effect

Active Publication Date: 2015-10-21
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the long preparation time and animal origin in the above hemostatic film preparation technology, the obtained cross-linked film has poor hemostatic effect, fast or slow degradation speed, texture It is relatively hard and brittle, and cannot better meet the clinical requirements. The present invention provides a preparation method of a bioabsorbable hemostatic membrane with short cross-linking time, good hemostatic effect, moderate degradation rate, uniform and soft texture and certain mechanical strength.

Method used

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  • A bioabsorbable hemostatic membrane
  • A bioabsorbable hemostatic membrane
  • A bioabsorbable hemostatic membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In order to investigate the effect of cellulose on the efficacy of the hemostatic membrane, in this example, hyaluronic acid / sodium carboxymethyl cellulose, hyaluronic acid / sodium hydroxyethyl cellulose and simple hyaluronic acid were prepared respectively The hemostatic membrane, compare the difference among the three.

[0033] (1) Use NaOH to adjust the pH value of deionized water to 10~12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution;

[0034] (2) Prepare three sets of gels: No. 1 dissolves 1000 kD sodium hyaluronate and 500 kD sodium carboxymethylcellulose in the mixed solution, and the mass ratio of sodium hyaluronate to sodium carboxymethylcellulose is 4 : 1, mix well and fully dissolve the biological polysaccharide, prepare sodium hyaluronate and sodium carboxymethylcellulose with 10% gel Ⅰ, the amount of 1,4-butanediol diglycidyl ether accounts for 10% of hyaluronic acid 1.25% of the total mass of sodium alginate and sodium carbo...

Embodiment 2

[0041] (1) Use NaOH to adjust the pH value of deionized water to 10~12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution;

[0042] (2) Prepare three groups of gels, the mass ratio of sodium hyaluronate to sodium carboxymethylcellulose is 2:1, and the mass ratio of sodium hyaluronate to sodium alginate is 1:0.1; in gel Ⅰ, 1, The amount of 4-butanediol diglycidyl ether added is 1.25% of the total weight of sodium hyaluronate and sodium hydroxymethylcellulose: No. 1 dissolves 1500 kD sodium hyaluronate and 500 kD sodium carboxymethylcellulose in In the mixed solution, mix evenly and fully dissolve the biopolysaccharide, prepare gel I with a sodium hyaluronate concentration of 10% and a sodium carboxymethylcellulose concentration of 5%, react at 35°C for alkaline cross-linking for 4 h, and then add Gel II with 1500 kD 1% sodium alginate and cross-linking agent dissolved, the amount of 1,4-butanediol diglycidyl ether in gel II is half of that in gel I, a...

Embodiment 3

[0049] In this example, the effects of hyaluronic acid with different molecular weights on the physicochemical properties and hemostatic application effect in the preparation of the hemostatic film were investigated.

[0050] (1) Use 0.25 N NaOH to adjust the pH value of deionized water to 10~12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution;

[0051] (2) Dissolve sodium hyaluronate and 500 kD sodium carboxymethyl cellulose with molecular weights of 500 kD, 1000 kD, 1500 kD and 2000 kD respectively in the mixed solution. The mass ratio is 2:1, 1,4-butanediol diglycidyl ether accounts for 1.25% of the total weight of sodium hyaluronate and sodium carboxymethyl cellulose, mix well and fully dissolve the biological polysaccharide to prepare sodium hyaluronate Gel Ⅰ with a concentration of 10% was reacted at 35°C for alkaline cross-linking for 4 h;

[0052] (3) Add 500 kD sodium alginate into deionized water mixed with 1,4-butanediol diglycidyl ethe...

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Abstract

The invention relates to the technical fields of surgical hemostasis and chronic heal wound hemostasis and wound protection, and in particular relates to a biodegradable hemostatic membrane. Alkaline crosslinking is carried out on sodium hyaluronate, a cellulose derivative and a cross-linking agent to obtain gel I; sodium alginate or sodium hyaluronate and 1,4-Butanediol diglycidyl ether are mixed to obtain gel II; the gel I and the gel II are mixed and cross-linked, and then purified and dried, and subjected to film formation under pressure to obtain the biodegradable hemostatic membrane. The obtained membrane is loose in structure and high in safety, easily attaches to and disperses on the surface of a wound, quick to stop bleeding, good in biocompatibility, suitably adjustable in in-vivo degradation time, wide in application range, low in cost, short in process period, little in pollution, low in energy consumption and easy for realizing industrialization, and has the good functions of stopping bleeding, promoting healing and preventing inflammation.

Description

technical field [0001] The invention relates to the technical field of surgical hemostasis and chronic healing wound hemostasis and wound protection, in particular to a bioabsorbable hemostatic membrane. Background technique [0002] Extensive bleeding and oozing are common problems in surgery and trauma surgery, especially for solid organs with multiple vessels. Trauma is often accompanied by coagulation dysfunction caused by massive blood loss. Commonly used traditional methods of hemostasis, such as direct compression and ligation, are difficult to be effective, and effective hemostatic materials are needed to achieve the hemostatic effect. At present, the main absorbable hemostatic materials at home and abroad include fibrin glue, gelatin sponge, oxidized cellulose, microfibrous collagen, chitosan and calcium alginate fiber. [0003] The material used as an ideal hemostatic dressing or hemostatic agent should have good hemostatic performance, excellent biocompatibility...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/64
Inventor 刘建建郭学平冯晓毅杨莹莹张燕李超耿凤
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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