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Preparation method for biomimetic mussel adhesive used for adhesion on wet surface and underwater curing

A technology of surface bonding and underwater curing, used in adhesives, non-polymer adhesive additives, adhesive additives, etc.

Inactive Publication Date: 2014-08-06
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a preparation method of bionic mussel glue that can be bonded on a wet surface and solidified underwater, so as to solve the problem of existing bionic mussel glue. The problem of low bonding strength in wet environment and underwater bonding

Method used

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  • Preparation method for biomimetic mussel adhesive used for adhesion on wet surface and underwater curing
  • Preparation method for biomimetic mussel adhesive used for adhesion on wet surface and underwater curing
  • Preparation method for biomimetic mussel adhesive used for adhesion on wet surface and underwater curing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023] Add N-vinylpyrrolidone ( NVP )( 2.22g 0.02mol), catechol derivatives MSt (0.10g 0.6mmol) and THF (5mL), AIBN (0.04mmol 6.6mg) was added, argon flowed for 30min, and the reaction was carried out at 60°C for 24h. Cool down to room temperature, precipitate in normal hexane (100mL), dissolve and precipitate the precipitate three times, and dry to obtain the copolymer I m (2.1g) (M n =51KDa M w / M n =1.7).

[0024] Add the prepared copolymer in the 50ml reaction bottle I m , tetrahydrofuran (6mL), boron tribromide (0.7g 2.8mmol), and react under the protection of argon for 10 hours. The concentrated reaction solution was dropped into n-hexane (50mL) under stirring, and the precipitate was dissolved and precipitated three times, and dried to obtain the polymer I′ m (1.7g). polymer I′ m Dissolve in 2mL of absolute ethanol, add 0.03g of ferric chloride, stir evenly to obtain bionic mussel glue.

Embodiment 2

[0026]

[0027] Add N-vinylpyrrolidone ( NVP )( 2.22g 0.02mol), catechol derivatives BSt (3.64g 0.1mol) and THF (10mL), add AIBN (0.4mmol 66mg), flow argon for 30min, and react at 60°C for 48h. Cool down to room temperature, precipitate in normal hexane (100mL), dissolve and precipitate the precipitate three times, and dry to obtain the copolymer I B (4.1g) (M n =4.9KDa M w / M n =2.1).

[0028] Add the prepared copolymer in the 50ml reaction bottle I B , tetrahydrofuran (15mL), concentrated hydrochloric acid (2mL), and reacted for 10 hours under the protection of argon. The concentrated reaction solution was dropped into n-hexane (50mL) under stirring, and the precipitate was dissolved and precipitated three times, and dried to obtain the polymer I′ B (3.1g). polymer I′ B Dissolve in 35mL of absolute ethanol, add 0.57g of ferric chloride, and stir evenly to obtain biomimetic mussel glue (when the base material is aluminum, the bonding strength is 1.2MPa aft...

Embodiment 3

[0030]

[0031] Add N-vinylpyrrolidone ( NVP )( 2.22g 0.02mol), catechol derivatives ENVP (0.32g 0.6mmol) and THF (10mL), add AIBN (0.5mmol 82mg), flow argon for 30min, and react at 60°C for 48h. Cool down to room temperature, precipitate in normal hexane (100mL), dissolve and precipitate the precipitate three times, and dry to obtain the copolymer Ⅱ E (2.0g) (M n =5.1KDa M w / M n =1.8).

[0032] Add the prepared copolymer in the 50ml reaction bottle Ⅱ E , tetrahydrofuran (15mL), concentrated hydrochloric acid (2mL), and reacted for 10 hours under the protection of argon. The concentrated reaction solution was dropped into n-hexane (50mL) under stirring, and the precipitate was dissolved and precipitated three times, and dried to obtain the polymer Ⅱ′ E (1.4g). polymer Ⅱ′ EDissolve in 10mL of absolute ethanol, add ferric chloride according to 1 / 3 (mol fraction) of the catechol group content in the polymer, and stir evenly to obtain bionic mussel glue (when t...

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Abstract

The invention relates to a preparation method for a biomimetic mussel adhesive used for adhesion on a wet surface and underwater curing. The method is characterized in that the biomimetic mussel adhesive is composed of two components including A and B, wherein the component A is a methanol solution of a polymer containing catechol groups; the polymer containing catechol groups is obtained in the manner that N-vinyl pyrrolidone and a polymerizable catechol derivative monomer are subjected to free radical polymerization and further subjected to deprotection; the component B is a crosslinking curing agent. The method has the advantages as follows: 1, the synthetic method is simple and efficient, raw material and reagents used in the reaction process are low in price and easy to get, and amplification in the operation process and industrial production are facilitated; 2, the biomimetic mussel adhesive has certain biocompatibility and initial adhesion performance, can be used for adhesion on the wet surface and underwater curing, and has the bonding strength being over 1 MPa, so as to be applied to adhesion of human tissue and adhesion in the wet environment of commonly-used base material as well as adhesion under the water. According to the invention, perfect combination between synthetic macromolecule and natural mussel attachment proteins is successfully realized, the technical bottleneck about the current biomimetic mussel adhesive is expected to break through, and meanwhile, a new approach for shellfish-based development of biomimetic high polymer material is provided.

Description

technical field [0001] The invention relates to a preparation method of bionic mussel glue that can be bonded on a wet surface and solidified underwater, in particular to a bionic mussel glue based on polyvinylpyrrolidone with higher strength and better biocompatibility Preparation. Background technique [0002] Bonding and underwater curing under water or humid environment has always been one of the difficulties in the field of adhesives. Most synthetic adhesives (such as: cyanoacrylate adhesives) are difficult to realize under water or Strong adhesion in wet environment. Due to its unique physiological structure, mussels have attracted much attention due to their strong adhesion in humid water environments. The study found that there is a large amount of 3, 4-dihydroxyphenylalanine (DOPA, dopa) in the mussel silk foot adhesion-related protein. The catechol group in DOPA has a strong coordination ability, which can form a reversible organometallic complex with metals, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J125/18C09J139/04C09J11/04C08F212/14C08F226/10C08F8/12C08F226/06
Inventor 穆有炳李爱磊万晓波贾明辰王德龙
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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