Three-dimensional cod-liver oil emulsion

A three-dimensional cod liver oil and emulsion technology, which is applied in the direction of emulsion delivery, oil/fat/wax non-active ingredients, medical preparations of non-active ingredients, etc. It can solve the problems of instability, vitamin C instability, and inability to completely solve degradation problems, etc. problems, achieve low processing costs, mature preparation process routes, and lower blood lipids and cholesterol

Active Publication Date: 2014-08-27
QINGDAO DOUBLE WHALE PHARMA
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0002] The main components of three-dimensional cod liver oil emulsion are vitamins A, D, and C. Vitamins A and D are essential substances for human growth and development, especially for the development of fetuses and infants, the integrity of epithelial tissues, vision, blood calcium and phosphorus, and bones. It plays an important role in the growth and development of teeth and teeth. Vitamin C participates in the formation of antibodies, collagen and tissue repair in the body, as well as the metabolism of sugar, fat and protein, and maintains the integrity of blood vessels. Various diseases caused by deficiency, such as night blindness, xerophthalmia, corneal softening, rickets, rickets, etc.; traditionally, three-dimensional cod liver oil emulsion is an oil-in-water emulsifier, that is, an o / w emulsion. The main components of the product contain fat-soluble vitamins A, D and water-soluble vitamin C. Vitamin C is dissolved in the water phase of the emulsion. The following two methods are adopted: one is to refer to the production method of vitamin C injection, and the whole production process should be carried out in an anaerobic environment, and supplementary materials such as chelating agent and antioxidant are added, because the three-dimensional cod liver oil emulsion is an oral emulsion, and it is multi-dose packaging, so its processing and preparation process is difficult to achieve the whole process of anaerobic, the use of this strict control process can only alleviate the degradation of vitamin C, and can not completely solve the problem of degradation; the second is to make vitamin C into inclusion complexes, liposomes and other applications in solid preparations and semi-solid preparations, this inclusion compound is not suitable for emulsions

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  • Three-dimensional cod-liver oil emulsion

Examples

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Effect test

Embodiment 1

[0013] Example 1: Preparation of a three-dimensional cod liver oil emulsion suitable for adults.

[0014] In this example, 1000g of three-dimensional cod liver oil emulsion is prepared, and the contents of each component are as follows: oil phase: cod liver oil 10g, vitamin A 0.062g, vitamin D 0.163mg, soybean oil 652g; emulsifier: vitamin C 1.54g; soybean lecithin 5.235g; The rest is purified water in the aqueous phase; 79 g of anhydrous ethanol is required.

[0015] The preparation process of the present embodiment is:

[0016] (1) after adding the soybean lecithin of commercially available product in 79g absolute ethanol, stirring and dissolving, it is mixed with soybean lecithin solution;

[0017] (2) after the vitamin C of the commercially available product is passed through a 100-mesh sieve, it is placed in a conventional boiling drying bed, and the soybean phospholipid solution prepared in step (1) is sprayed into the drying bed under the boiling state, and the tempera...

Embodiment 2

[0019] Example 2: Preparation of a three-dimensional cod liver oil emulsion suitable for children.

[0020] In this example, 1000g of three-dimensional cod liver oil emulsion is prepared, and the contents of each component are as follows: oil phase: cod liver oil 10g, vitamin A 0.03g, vitamin D 0.338mg, soybean oil 652g; emulsifier: vitamin C 1.54g, soybean lecithin 5.235g; The rest is purified water in the aqueous phase; 79 g of anhydrous ethanol is required.

[0021] The preparation process of the present embodiment is:

[0022] (1) first adding soybean lecithin into dehydrated alcohol, after stirring and dissolving, it is prepared into soybean lecithin solution;

[0023] (2) passing the vitamin C through a 100-mesh sieve, placing it in a boiling drying bed, spraying the soybean lecithin solution in a boiling state, and drying at 45-55° C. to prepare vitamin C soybean lecithin microcapsules;

[0024] (3) Dissolve cod liver oil, vitamin A and vitamin D in soybean oil in tur...

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Abstract

The invention belongs to the technical field of medicine preparation and relates to a novel three-dimensional cod-liver oil emulsion. The three-dimensional cod-liver oil emulsion comprises an oil phase, a water phase and an emulsifying agent, wherein the oil phase comprises soybean oil, cod-liver oil, the vitamin A and the vitamin D, the water phase is purified water, and the emulsifying agent comprises vitamin C soyabean lecithin micro-capsules. The preparing technology includes the steps of preparing a soyabean lecithin solution, preparing the phosphatide micro-capsules and emulsifying, wherein soyabean lecithin is added into absolute ethyl alcohol and completely dissolved through stirring to obtain the soyabean lecithin solution; the vitamin C is put into a boiling drying bed, and the soyabean lecithin solution is sprayed into the boiling drying bed to obtain the vitamin C soyabean lecithin micro-capsules after drying; the cod-liver oil, the vitamin A and the vitamin D are dissolved in the soybean oil through mixing and stirring, the vitamin C soyabean lecithin micro-capsules and the purified water are sequentially added and evenly stirred, and then reverse tangent emulsifying is carried out to obtain the three-dimensional cod-liver oil emulsion finished product. The preparing technology is mature in route, and the three-dimensional cod-liver oil emulsion is rich in nutrient, good in mouthfeel and taste, low in processing cost, safe and reliable.

Description

Technical field: [0001] The invention belongs to the technical field of pharmaceutical preparation, and relates to a technology for preparing a three-dimensional cod liver oil emulsion, in particular to a novel three-dimensional cod liver oil emulsion prepared by adding vitamin C from an aqueous phase of the emulsion to an emulsified layer. Background technique: [0002] The main components of the three-dimensional cod liver oil emulsion are vitamins A, D, and C. Vitamin A and D are essential substances for human growth and development, especially for the development of fetuses, infants and young children, the integrity of epithelial tissue, vision, blood calcium and phosphorus. It plays an important role in the growth and development of teeth. Vitamin C participates in the formation of antibodies, collagen and tissue repair in the body, as well as the metabolism of sugar, fat and protein, and maintains the integrity of blood vessels. Various diseases caused by deficiency, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/59A61K47/24A61K47/44A61P3/02A61P27/02A61P19/08A61K31/375A61K31/07
Inventor 耿仕霞倪志伟卢大峰杨珊珊白建宏
Owner QINGDAO DOUBLE WHALE PHARMA
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