Upconversion composite nano-material as well as preparation method and application thereof

A composite nanomaterial and composite nanoparticle technology, which is applied in the directions of wave energy or particle radiation treatment materials, drug combinations, and pharmaceutical formulations, can solve the problems of unsuitability for luminescence, heat generation, and low luminous efficiency, and achieve stable luminescence and a simple method. , the effect of high fluorescence intensity

Active Publication Date: 2014-10-08
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, metal nanomaterials have low luminous efficiency when they generate heat, so they are not suitable for simultaneous luminescence and heat generation.

Method used

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  • Upconversion composite nano-material as well as preparation method and application thereof
  • Upconversion composite nano-material as well as preparation method and application thereof
  • Upconversion composite nano-material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Such as figure 1 As shown, the up-conversion composite nanoparticles synthesized in this example are monodisperse nanoparticles with uniform size, and the size is 20-30 nm. The core heating layer of nanoparticles is NaYF 4 :90%Nd 3+ , the excitation wavelength is 800nm. The outer light-emitting layer is NaYF excited by 980nm laser 4 :20%Yb 3+ ,2%Er 3+ . Its concrete preparation method is as follows:

[0055] (1) Add 22.58mg of yttrium oxide and 302.8mg of neodymium oxide into a 100mL round-bottomed flask, add 2mL of concentrated hydrochloric acid to react, and then rotate to dryness.

[0056] (2) Add 9 mL of oleic acid and 9 mL of 1-octadecene. The solution was stirred and heated to 110°C under vacuum for 40 minutes.

[0057] (3) Then lower the temperature to 75°C, add 760 mg of solid sodium oleate and 148 mg of anhydrous ammonium fluoride. Then the solution was heated to 320°C and reacted for 80 minutes.

[0058] (4) After rapidly cooling to 75°C, add 9mL of...

Embodiment 2

[0065] Present embodiment except following feature other structures are with embodiment 1: as image 3 As shown, the up-conversion composite nanoparticles synthesized in this example have a 4-layer structure, and the first layer of core heating layer is NaYF 4 :90%Nd 3+ , the second layer is an isolation layer used to prevent energy quenching, specifically NaYF 4 , the third light-emitting layer is NaYF 4 :30%Nd 3+ ,0.5%Er 3+ ,1%Nd 3+ , while the shell of the fourth light-emitting layer is NaYF 4 :1%Nd 3+ , used to enhance the luminous intensity. Its concrete preparation method is as follows:

[0066] (1) Add 22.58mg of yttrium oxide and 302.8mg of neodymium oxide into a 100mL round-bottomed flask, add 2mL of concentrated hydrochloric acid to react, and then rotate to dryness.

[0067] (2) Add 6.06mL of oleic acid, 4.82mL of oleylamine and 9mL of 1-octadecene. The solution was stirred and heated to 110°C under vacuum for 40 minutes.

[0068] (3) Then lower the tempe...

Embodiment 3

[0083] Present embodiment except following feature other structures are with embodiment 1: as Figure 5 As shown, the up-conversion composite nanoparticles synthesized in this example have a three-layer structure, and the first layer of core heating layer is NaYF 4 :90%Nd 3+ , the second layer is an isolation layer used to prevent energy quenching, specifically NaYF 4 , the third light-emitting layer is NaYF 4:30%Nd 3+ ,0.5%Er 3+ ,1%Nd 3+ . Its specific preparation method is exactly the same as (1)-(12) of embodiment 2.

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Abstract

The invention discloses an upconvresion composite nano-material as well as a preparation method and application thereof. The nano-material is of a core-shell structure, and comprises synthetic Nd<3+>-doped 800nm laser excited nano-particles with a heating effect, an upconversion fluorescence nano-shell layer coating the outer layer, an isolating layer which can be added in the middle depending on the difference of outer layer materials, and a shell layer which is additionally arranged outside an illumination layer to intensify the illumination strength. The method for synthesizing the nano-particles is simple, easy to operate and strong in controllability, and particles with different diameters can be synthesized by controlling the usage of raw materials. The nano-particles synthesized by the method integrate the independent photothermal effect of the material and the upconversion illumination effect, and can be applied to preparation of tumor diagnosis preparations, temperature detection reagents and tumor treatment medicaments, and biological imaging.

Description

technical field [0001] The invention relates to the fields of nanomaterial preparation and nanobiophotonics research, in particular to an up-conversion composite nanomaterial and its preparation method and application. Background technique [0002] In recent years, up-conversion luminescent nanomaterials have become the focus of research due to their special properties and wide applications. potential application value. Compared with traditional organic dyes and semiconductor quantum dots, up-conversion luminescent nanomaterials have special luminescent properties, that is, they can absorb two or more low-energy photons and radiate one high-energy photon, usually converting near-infrared light into visible light, and near-infrared light Infrared light has the advantages of deep tissue penetration, little damage to organisms, and no autofluorescence. At the same time, upconversion nanoparticles are non-toxic, non-photobleaching, and easy to convert to biocompatibility. Thes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K41/00A61P35/00
Inventor 詹求强刘静
Owner SOUTH CHINA NORMAL UNIVERSITY
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