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Application of rheum lhasaense extract A and B in preparation of biological preparation for reducing blood fat

A technology of Lhasa rhubarb and biological preparations, which is applied in the field of biomedicine and can solve the problems of no biological activity

Inactive Publication Date: 2014-11-26
昆明翔昊科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of rheum lhasaense extract A and B in preparation of biological preparation for reducing blood fat
  • Application of rheum lhasaense extract A and B in preparation of biological preparation for reducing blood fat
  • Application of rheum lhasaense extract A and B in preparation of biological preparation for reducing blood fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Structural Analysis of Lhasa Emodin A and Lhasa Emodin B

[0025] Lhasa emodin A is light yellow powder, its optical rotation is: (C=0.0056, MeOH) Molecular ion peak m / z679[M-H] given by (-)ESI-MS + (HR-ESI-MS: 680.9614, calculated for C 42 h 32 o 9 , see attached figure 1 ) to determine the molecular formula as C 42 h 32 o 9 , with an unsaturation of 27. analysis of compounds 1 H NMR and 1 H- 1 H COZY Spectrum: Aromatic Hydrogen Signal δ H 7.12(d, J=8.5Hz, 2H), δ H 6.77(d, J=8.5Hz, 2H) and δ H 7.16(d, J=8.5Hz, 2H), δ H 6.75(d, J=8.5Hz, 2H) indicates that there are two A in the molecule 2 B 2 system, denoted as A 1 Ring and C 1 ring; delta H 6.10(d, J=2.0Hz, 2H), δ H 6.14(t, J=2.0Hz, 1H) and δ H 6.10(d, J=2.0Hz, 2H), δ H 6.17(t, J=2.0Hz, 1H) indicates that the molecule contains two AX 2 system, denoted as A 2 and C 2 ring; delta H 6.74(d, J=8.0Hz, 1H), δ H 7.21(d,J=8.0Hz,1H) and δ H 6.94(br s,1H) indicates that the molecule contai...

Embodiment 2

[0033] Example 2: Research on the lipid-lowering effect of the lipid-lowering effect research series samples in Lhasa

[0034] 1 material

[0035] 1.1 Drugs

[0036] S 1 Sample, yellow powder, is the research code of Lhasa Emodin A; S 2 The sample, yellow powder, is the research code of Lhasa Emodin B. Fenofibrate, 100mg / tablet, produced by Shanghai Yanan Vientiane Pharmaceutical Co., Ltd., batch number 121101. In the experiment, the S 1 The ~S2 sample and the positive control fenofibrate were formulated into a suspension at the desired concentration.

[0037] 1.2 Reagents

[0038] Triglyceride (TG, 1204101), cholesterol (TC, 1204101) kits, produced by Sichuan Mike Technology Co., Ltd.; cholesterol (13030) and sodium taurocholate (20131201) biochemical reagents, produced by Beijing Aoboxing Biochemical Technology Co., Ltd.

[0039] 1.3 Animals

[0040] SPF grade ICR mice; clean grade rat compound feed; provided by the Experimental Animal Center of Kunming Medical Colle...

Embodiment 3

[0058] Embodiment 3: Lhasa emodin tablet preparation

[0059]Preparation method: Weigh 100g of Lhasa emodin A or B, dissolve it in an appropriate amount of ethanol, add 900g of PVPK29 / 32, mix evenly, and fully dissolve; rotate the evaporation to evaporate the ethanol, cool, dry, solidify, crush the solidified product, and take 100g Mix with 50 grams of lactose, 30 grams of pregelatinized starch, and 10 grams of sodium carboxymethyl starch, pass through an 80-mesh sieve twice, mix well, and use 1% low-substituted hydroxypropyl cellulose ethanol solution (concentration 50%) as the viscosity Mixture soft material, pass through a 40 mesh sieve to granulate, dry at 60°C, pass through a 30 mesh sieve for granulation, add 1.5 grams of talc powder, mix evenly, and press into tablets to prepare 1,000 tablets of Lhasa emodin A or Lhasa emodin B tablets .

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Abstract

The invention discloses the chemical structural formulas of rheum lhasaense extract A and B, and an application of the rheum lhasaense extract A and B in the preparation of biological preparation for reducing blood fat. The two compounds have a prominent effect on reducing blood fat. Moreover the rheum lhasaense extract B may have a certain effect on treating fatty liver, and has a wide application in preparation of drugs for preventing and treating hyperlipidemia.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the medical application of two novel resveratrol trimer compounds Lhasa-emodin A and Lhasa-emodin B. Background technique [0002] Hyperlipidemia mainly refers to high serum total cholesterol (TC) or triglyceride (TG) levels and / or low serum high-density lipoprotein-cholesterol (HDL-C) levels. Hyperlipidemia is a common and frequently-occurring disease in middle-aged and elderly people. With the improvement of people's living standards and changes in living habits, the incidence of this disease has increased significantly, and the age of onset has also advanced. Atherosclerosis caused by hyperlipidemia is the main cause of coronary heart disease, hypertension and cerebrovascular disease. About 12 million people die of cardiovascular disease and cerebral apoplexy in the world every year. Therefore, the treatment of hyperlipidemia is very important, which has attracted great attention from...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61P3/06A61P1/16A23L1/29A23L33/00
Inventor 胡琳胡群
Owner 昆明翔昊科技有限公司
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