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Germanium nano cluster and preparation method and application thereof

A technology of nano-clusters and germanium dioxide, applied in the fields of chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems that have not been reported on semiconductor metal clusters, low fluorescence quantum yield, optical and optoelectronic devices Application limitations and other issues

Active Publication Date: 2014-12-03
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Silicon and germanium of the fourth main group, as indirect bandgap semiconductor materials, have been widely used in the field of microelectronics in the past few decades, but due to the extremely low fluorescence quantum yield at room temperature, their applications in the field of optical and optoelectronic devices has been limited
[0005] But so far, we have not seen reports of semiconductor metal clusters with fluorescent properties

Method used

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  • Germanium nano cluster and preparation method and application thereof
  • Germanium nano cluster and preparation method and application thereof
  • Germanium nano cluster and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Synthesize water-soluble germanium clusters as follows:

[0069] (1) Weigh 0.06g of sodium hydroxide and dissolve it in 10ml of water, and ultrasonically dissolve it to make a sodium hydroxide solution;

[0070] (2) Weigh 0.26g germanium dioxide (GeO 2 , purchased from Sigma-Aldrich Shanghai Trading Co., Ltd., product number 483702) was dissolved in the sodium hydroxide solution in step (1), and ultrasonically dissolved to obtain a germanium source solution;

[0071] (3) Dissolving the germanium source in a sodium hydroxide solution under ultrasonic radiation conditions to prepare a germanium source solution, and adjusting the pH value of the germanium source solution in step (2) to between 6 and 7 with dilute hydrochloric acid;

[0072] (4) Add 1.21g of cysteine ​​(purchased from Sigma Aldrich Shanghai Trading Co., Ltd., product number 30089-25G) into 9ml of ultrapure water, stir to fully dissolve cysteine, and prepare cysteine The aqueous solution; The concentration...

Embodiment 2

[0081] In this example, germanium clusters were prepared according to the same method as in Example 1, the only difference being that the amount of cysteine ​​used was 0.121 g.

[0082] According to the same characterization method in Example 1, the fluorescence spectrum of the germanium clusters obtained in this comparative example is very different from Example 1 by using a fluorescence spectrometer, the emission peak position is red-shifted to 530nm, and the excitation peak position is blue-shifted to 385nm. Using sodium fluorescein as a fluorescent standard substance to measure the fluorescence quantum yield of the germanium clusters obtained in this embodiment is above 20%, indicating that the proportioning concentration of cysteine ​​and germanium sources has a certain effect on the fluorescent properties of the synthesized clusters. Impact.

Embodiment 3

[0084] (1) Weigh 0.02g of potassium hydroxide and dissolve it in 10ml of water, and ultrasonically dissolve it to make sodium hydroxide solution;

[0085] (2) Weigh 0.026g germanium dioxide (GeO 2 , purchased from Sigma-Aldrich Shanghai Trading Co., Ltd., product number 483702) was dissolved in the sodium hydroxide solution in step (1), and ultrasonically dissolved to obtain a germanium source solution;

[0086] (3) Under the condition of ultrasonic radiation, dissolving the germanium source in a sodium hydroxide solution to prepare a germanium source solution, and adjusting the pH value of the germanium source solution in step (2) to 9 with dilute hydrochloric acid;

[0087] (4) Add 0.0605g of cysteine ​​(purchased from Sigma-Aldrich Shanghai Trading Co., Ltd., product number 30089-25G) into 9ml of ultrapure water, stir to fully dissolve cysteine, and prepare cysteine The aqueous solution; The concentration of the aqueous solution of cysteine ​​is 0.05mmol / ml;

[0088] (5) ...

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Abstract

The invention relates to a germanium fluorescence nano cluster, a preparation method of the germanium fluorescence nano cluster in aqueous solution and application of the germanium fluorescence nano cluster to biological imaging. According to the synthetic method, the germanium nano cluster which is protected by a monomolecular layer and has fluorescent property is prepared by using germanium dioxide as a germanium source, using small biological molecule cysteine as a protective agent and using sodium borohydride as a reducing agent. Raw materials used in the preparation method are simple and easy to obtain, have stable performance and have no toxicity; the reaction process does not need to be protected by high-temperature and inert gas and is simple and easy to operate; compared with a precious metal nano cluster which is reported before, the obtained germanium quantum dots with emerald or yellow fluorescent light has higher fluorescent quantum yield, has the cluster size of about 1nm, has good water solubility, has no cytotoxicity and can be well applied to biological cell imaging.

Description

technical field [0001] The invention relates to a germanium nanocluster, its preparation method and application, in particular to a germanium nanocluster with strong fluorescence properties, its preparation method and its application in biological imaging. Background technique [0002] Silicon and germanium of the fourth main group, as indirect bandgap semiconductor materials, have been widely used in the field of microelectronics in the past few decades, but due to the extremely low fluorescence quantum yield at room temperature, their applications in the field of optical and optoelectronic devices has always been limited. In recent years, with the rapid development of nanotechnology, new breakthroughs have been made in the research of semiconductor materials silicon and germanium. When they are at the nanometer scale, due to the quantum confinement effect, they will transform into nanomaterials with direct band gaps, showing different characteristics. The unique physical ...

Claims

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Application Information

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IPC IPC(8): B22F9/24C09K11/66G01N21/64
Inventor 聂广军李凤
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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