Low-particle precipitation medical polypropylene material as well as application and preparation method thereof

Abstract

The invention belongs to the technical field of medical polymers, and discloses a low-particle precipitation medical polypropylene material as well as application and a preparation method thereof. The low-particle precipitation medical polypropylene material is prepared from the following components in parts by mass: 50-80 parts of polypropylene, 1-5 parts of low-molecular weight polyolefin wax, 10-35 parts of vinyl elastomer, 5-15 parts of auxiliary crosslinked elastomer, 0.005-0.05 part of modifying peroxide and 0.01-0.5 part of an antioxidant. The preparation method comprises the following steps: uniformly mixing the polypropylene, the vinyl elastomer, the auxiliary crosslinked elastomer and the antioxidant, adding into an extruder, melting and kneading at 150-200 DEG C, uniformly mixing and dispersing the modifying peroxide and the low-molecular weight polyolefin wax, adding into the extruder, continuously extruding, cooling, and pelletizing to obtain the medical polypropylene material. The preparation method can be used for preparing combined covers for large infusion packages, medical sanitary equipment or medicine storage containers.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to a medical polypropylene material with low particle precipitation and its preparation method and application. Background technique [0002] Since pharmaceutical packaging materials involve direct contact with drugs, they will have a significant impact on the properties of drugs, and thus are closely related to human life and health. Among them, the medicine in the large infusion packaging material is directly injected into the venous blood, so there are very high requirements on the cleanliness and safety of the infusion. The defect of the traditional glass infusion container is that the glass will interact with the liquid medicine to produce debris, and when the liquid medicine enters the human body, it may block capillaries and cause edema and phlebitis. The second-generation infusion container is made of polyvinyl chloride. Although no debris will...

AI Technical Summary

Problems solved by technology

The defect of the traditional glass infusion container is that the glass will interact with the liquid medicine to produce debris, and when the liquid medicine enters the human body, it may block capillaries and cause edema, phlebitis

The second-generation infusion container is made of polyvinyl chloride. Although no debris will be produced, the polyvinyl chloride itself needs to be processed with a plasticizer. The plasticizer is dissolved in the liquid medicine and then injected directly into the human body. If the patient Long-term use will affect human hematopoietic function, and even have the risk of cancer

[0003] However, polypropylene material still does not completely overcome the disadvantages of glass bottles as an infusion packaging material.

For example, the transparency after disinfection is poor, which brings difficulties to the clarity test; the low temperature resistance is not good, and it is unfavorable to transport at low temperatures in the north; parts other than the bottle body, such as the material of the outer cover and inner cover of the combination cover, may also be in the drug solution. Introduce contaminants such as insoluble particulates

Poor transparency and transportation can be solved by temperature control and other measures. However, due to the particularity of use, the combined cover material needs to be modified, such as it needs to be opened with a small force and can adapt to complex processing and molding.

The Chinese invention patents with patent numbers 200410024446.4 and 201110220700.8 both disclose several modification methods for combined cap materials, which solve the problems of welding performance of polypropylene bottle body, opening force of pull ring, irregular opening edge, insufficient dimensional stability, Small molecule precipitation and other issues, but the problem of particle precipitation that may be brought about by modification is not considered

In addition, when parts factories and pharmaceutical factories inject composite caps, the containers used for collection and temporary packaging are often made of modified polypropylene, which may cause particle pollution to the composite cap during the process.

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