Method for preparing granularity controllable narrow range polymer micro-nano spheres

Abstract

The invention discloses a method for preparing granularity controllable narrow range polymer micro-nano spheres. The granularity controllable narrow range polymer micro-nano spheres can be efficiently and continuously produced at normal temperature by using industrial grade polydisperse polymer products, recovered polymer materials, homopolymers and copolymers which are wide in source as raw materials by virtue of a two-step production process of mechanical stirring-micro jet flow. In a preparation process, the proportion of a dispersed phase to a continuous phase, the type and use level of surfactants and compounding schemes of types of organic solvents and high pressure chamber of the device are adjusted without high-temperature time-consuming polymerization reaction and cockamamie post-treatment as well as purification of raw materials, so that the grain size and grain size distribution of the micro-nano spheres can be controlled. The diameters are adjustable from 30nm to 3mu m, the polydispersity index is less than 0.2, and the micro-nano spheres are smooth and non-adhesive on the surfaces and can be re-dispersed in a solvent. The obtained polymer micro-nano spheres have a wide application range in the fields of standard metering, food industry, medicines, bioengineering, coating and plastic processing and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of polymer micro-nanospheres, and in particular relates to a method for preparing polymer micro-nanospheres with controllable particle size and narrow distribution, which is suitable for mass production of most polymers. Background technique [0002] Polymer microspheres have the characteristics of large specific surface area and strong adsorption. With different types of polymers, polymer microspheres can exhibit many excellent properties. For example, monodisperse cross-linked polystyrene microspheres have good adsorption properties and mechanical properties; polyacrylamide microspheres have the characteristics of strong surface reaction ability, easy functionalization and biocompatibility; polyethylene glycol-modified polylactic acid- Glycolic acid block copolymer nanospheres, as a new type of drug carrier, have received widespread attention in the application of gene therapy. The applicat...

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Problems solved by technology

[0004] However, there are some shortcomings in the preparation method of the above-mentioned polymer microspheres: (1) the particle diameter of the polymer microspheres prepared by the suspension polymerization method is generally between 100 μm and 2000 μm, and the particle size distribution is usually very wide; The particle size distribution of microspheres prepared by the method is also very wide, and usually only microspheres with a particle size of less than 0.5 μm can be prepared, and the particle size is not controllable; the selection range of polymers for dispersion polymerization and precipitation polymerization is narrow; membrane emulsification Usually only micron-scale monodisperse microspheres can be prepared by the microfluidic method; the microfluidic method is limited by the size of the capillary channel, and it is usually difficult to prepare microspheres with a particle size of less than 100 μm, and its flow rate is slow, which cannot meet the needs of rapid and efficient production

However, its application is currently mainly concentrated in the fields of food and biochemical pharmaceuticals, such as the preparation of injection emulsions and cell wall breaking, etc., and most of the industrial-grade polymer systems and block copolymer systems with different functional groups prepared in the laboratory have not been studied. , the control of particle size and distribution after homogenization has not been reported

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