A controllable method for preparing nanofibers with core-shell structure

A nanofiber, core-shell structure technology, applied in the field of preparation of functionalized nanofibers, can solve the problems of nanofiber membrane cross-linking polymerization, inflexibility, cumbersome experimental steps, etc., and achieve good biocompatibility and high medical value Effect

Active Publication Date: 2017-01-18
BEIJING UNIV OF CHEM TECH
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Problems solved by technology

The experimental steps of this method are relatively cumbersome, and it is difficult to obtain uniform core-shell nanofibers by coating, which can easily lead to cross-linking and polymerization of the entire nanofiber membrane.
Patent No. CN103498211A introduces a method for preparing nanofibers with a core-shell structure by migration-type phase separation. This method utilizes the characteristics of spontaneous outward migration of fluoropolymers with low surface energy, and blends fluoropolymers with complex polymers for electrostatic Spinning, however, this method is not flexible, and the content of fluoropolymer must be kept higher than that of compound polymer to obtain ideal core-shell structure nanofibers

Method used

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  • A controllable method for preparing nanofibers with core-shell structure

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Effect test

Embodiment 1

[0021] 1) Preparation of electrospinning solution: prepare DMF / C with a molecular weight of 20,000 g / mol polyvinylpyrrolidone at a concentration of 30 wt % 3 h 6 The volume ratio of O is 1:1 composite solvent solution, after it is completely dissolved, 5wt% fluorine-containing epoxy monomer 3-(perfluoro-n-hexyl) propylene oxide and 1wt% mixed type adding triarylsulfonium hexafluorophosphate into the polymer solution, fully stirring, and obtaining an electrospinning solution after it is completely dissolved;

[0022] 2) Preparation of nanofibers with core-shell structure: electrospinning the electrospinning solution prepared in step 1) under UV light irradiation. The spinning voltage was set to 20kV, the distance from the spinning port to the receiver was 25cm, the diameter of the spinning port was 1.0mm, and the flow rate was controlled at 0.2mL / h. The light intensity at the center of the spinneret spindle is 400mw / cm 2 . Fluorine-containing core-shell nanofibers were prep...

Embodiment 2

[0024] 1) Preparation of electrospinning solution: prepare DMF / C with a molecular weight of 20,000 g / mol polyvinylpyrrolidone at a concentration of 25 wt % 3 h 6 The volume ratio of O is 1:1 composite solvent solution, after it is completely dissolved, 10wt% fluorine-containing epoxy monomer 3-(perfluoro-n-hexyl) propylene oxide and 2wt% mixed type adding triarylsulfonium hexafluorophosphate into the polymer solution, fully stirring, and obtaining an electrospinning solution after it is completely dissolved;

[0025] 2) Preparation of nanofibers with core-shell structure: electrospinning the electrospinning solution prepared in step 1) under UV light irradiation. The spinning voltage was set to 15kV, the distance from the spinning port to the receiver was 20cm, the diameter of the spinning port was 1.0mm, and the flow rate was controlled at 0.4mL / h. The light intensity at the center of the spinneret spindle is 350mw / cm 2 . Fluorine-containing core-shell nanofibers were pre...

Embodiment 3

[0027] 1) Preparation of electrospinning solution: prepare DMF / C with a molecular weight of 20,000 g / mol polyvinylpyrrolidone at a concentration of 20 wt % 3 h 6 The volume ratio of O is 1:1 composite solvent solution, after it is completely dissolved, in the dark room, with respect to polymer content 8wt% fluorine-containing epoxy monomer 3-(perfluoro-n-hexyl) propylene oxide and 2wt% mixed type adding triarylsulfonium hexafluorophosphate into the polymer solution, fully stirring, and obtaining an electrospinning solution after it is completely dissolved;

[0028] 2) Preparation of nanofibers with core-shell structure: electrospinning the electrospinning solution prepared in step 1) under UV light irradiation. The spinning voltage was set to 10kV, the distance from the spinning port to the receiver was 17cm, the diameter of the spinning port was 1.0mm, and the flow rate was controlled at 0.6mL / h. The light intensity at the center of the spinneret spindle is 300mw / cm 2 . F...

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Abstract

The invention discloses a preparation method for controllable core-shell structure nanofiber and belongs to the field of functional nanofiber preparation. According to the preparation method for the controllable core-shell structure nanofiber, polymer is blended with micro-molecular cationic photoinitiator and fluorine-containing epoxy monomer, electro-spinning is performed under UV light irradiation by means of the characteristics that the macro molecule has high mobility, and the surface with a little of fluorine-containing compound is capable of migrating to the fiber surface, the functional fluorine-containing core-shell structure nanofiber with controllable thickness is prepared through controlling the dosage of the fluorine-containing monomer, wherein the core layer of the functional fluorine-containing core-shell structure nanofiber is polymer fiber while the surface is a fluorine-containing photo-polymerization cross-linked shell layer. The preparation method for the controllable core-shell structure nanofiber effectively prepares material through electro-spinning and photo-polymerization, the novel nanofiber has the excellent performances of the polymer fiber and fluorine-containing material, the performance is improved, and the application field is widened. The fiber has hydrophobic property, lipophobic property, pollution resistance, wearing resistance and the like, and the bio-compatibility is good; the nanofiber can be used for the fields of tissue engineering, wound repairing and the like, and the controllable core-shell thickness has high latent medical value in the drug sustained-release aspect.

Description

technical field [0001] The invention relates to a method for preparing controllable core-shell structure nanofibers, belonging to the field of preparation of functionalized nanofibers. Background technique [0002] Electrospinning is a fast and efficient method for preparing continuous nanofibers. It is easy to operate and simple in device. It is mainly composed of a high-voltage power supply, a liquid storage device with a conductive spinneret, and a collector. The nanofibrous membrane prepared by it has high porosity, large specific surface area, and good biomimetic performance. It is widely used in the fields of biological tissue engineering scaffolds, wound repair, drug controlled release, catalytic carriers, filter media, and biosensors. [0003] Photopolymerization is a rapid curing technology, which means that under the action of light (including ultraviolet light, visible light) or high-energy rays (mainly electron beams), liquid oligomers (including monomers) under...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D5/34D01D5/00D01D1/02D01F8/10D01F8/08D01F8/14D01F8/16
CPCD01D1/02D01D5/003D01D5/34D01F8/08D01F8/10D01F8/14D01F8/16
Inventor 马贵平牛其建聂俊姜程林
Owner BEIJING UNIV OF CHEM TECH
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