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The present application relates to a kind of bionic lymph node organoids and its construction method, the organoids include in three-dimensional space: one B cell-rich core region;And one T cell-rich region, it is at least partially wrapped in the core region in space;Wherein, the core region can be differentiated to form the light area and dark area with structural difference in response to external stimulation.The method includes preparing first bioink and second bioink, the first bioink contains B lymphocyte, and the second bioink contains T lymphocyte;Using the first and second bioink, the organoid prototype with the spatial structure of T cell-rich region wrapping B cell-rich region is formed by three-dimensional construction technology;The organoid prototype is solidified to stabilize its structure;External stimulation is applied to the structure after solidification, and the B cell-rich region is differentiated to form light area and dark area.