Niclosamide ethanolamine salt wettable powder as well as preparation method and application thereof

Abstract

The invention provides niclosamide ethanolamine salt wettable powder as well as a preparation method and application thereof. The wettable powder is prepared from niclosamide ethanolamine salt, a dispersing and wetting agent, a suspension aid and an anti-caking agent, wherein the dispersing and wetting agent is a compound mixture of fatty alcohol-polyoxyethylene ether and a non-ionic hydroxyl polyethylene oxide block copolymer, and the use amount of the dispersing and wetting agent accounts for 8-15% of the total weight of the raw materials. By using the compound mixture of the fatty alcohol-polyoxyethylene ether and the non-ionic hydroxyl polyethylene oxide block copolymer as the dispersing and wetting agent, a unique steric hindrance effect is provided in the system, so that the stability of the system is effectively kept and the problems of slow wetting, color change and flocculation are solved; the wettable powder is short in wetting time, uniform in dispersion effect, relatively small in particle size distribution, capable of rapidly reaching a target site, free from flocculation for a long time and free from particle aggregation, so that the wettable powder has long-lasting efficacy and applicable to hard water. The wettable powder disclosed by the invention is applicable to the preparation of molluscicidal products and is good in molluscicidal effect.

Description

technical field

[0001] The invention relates to the technical field of molluscicide preparations, in particular to a niclosamide ethanolamine salt wettable powder and a preparation method and application thereof. Background technique

[0002] At present, niclosamide is the main molluscicide drug. It has no special smell, no irritation to the skin, low toxicity to humans and animals, and does not damage crops. It can be directly diluted with water for application. Moreover, the medicine has a large mollusc killing effect and a long-lasting effect. But the dissolubility and dispersibility of various powders of existing niclosamide are not ideal, not only the wetting time is long, and after diluting with water, the water surface changes from bright yellow to reddish brown soon. At the same time, flocculation occurs in the aggregation of drug particles, which not only pollutes the water surface, but also the active ingredients cannot be well dispersed evenly. The charge effect ...

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