Diffusion cell membrane module and diffusion cell

Abstract

The present invention relates to a diffusion cell membrane module, which provides at least a separate barrier compartment for various forms of conventional diffusion cells and is used for simulating the diffusion process that a substance passes through a monolayer or multi-layer semi-solid or non-solid barrier. The membrane module comprises an outer wall, filtration membranes, volume metering rings and an enhanced network, wherein at least the one barrier compartment is enclosed through the alternating and repeated alignment of the filtration membranes and the volume metering rings so as to separate the donor chamber and the acceptor chamber of the diffusion cell and allow the substance to diffuse and pass through.

Description

technical field [0001] Diffusion cells are usually composed of donor chambers, acceptor chambers, barrier fixing devices, maintenance devices, and sampling and detection devices, which can be used to simulate the diffusion process of substances (molecules, ions, particles, or droplets, etc.) through various barriers. in experimental studies related to diffusion. The membrane module involved in the invention is one of the barrier fixing devices in the diffusion pool system. Background technique [0002] Diffusion cells have been widely used in research fields such as medical science, catalysis science, environmental science, and geological science. Therefore, various types of diffusion cells have been produced to meet different research needs, such as providing barriers during the diffusion process. Oxygen diffusion cells are used for biofilm barriers in drug screening, diffusion cells that can monitor the electrochemical properties of both sides of the membrane during the d...

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Problems solved by technology

[0003] However, the patented technologies of these diffusion cells are mainly innovative in the way of sampling, monitoring, the way of maintaining the external environment of the diffusion pool and the way of maintaining the surrounding environment of the diffusion barrier, but there is no essential difference in the barrier fixing device (both through two frosting methods) blue plane clamp), so it can only be applied to the study of solid diffusion barriers with a certain strength, such as skin, gastrointestinal mucosa, rock flakes, catalyst carriers, etc. It is not suitable for some non-solid diffusion barriers, such as mucus layer (mucus-like liquid film distributed on the outside of the tissue mucosa), blood, face cream, semi-solid medium, monolayer cells, sludge in sewage treatment tanks, etc., because this special diffusion medium cannot be clamped between flanges form a complete barrier

[0004] Therefore, the conventional diffusion cell cannot meet the needs of research in some special cases. For example, in the study of oral drug dosage forms, it is necessary to simulate the process of the new dosage form passing through the intestinal wall and entering the blood. The intestinal wall is structurally composed of multiple layers. Its main obstacle is the mucus layer and the epithelial cell layer. The mucus layer is a viscous semi-solid or liquid substance composed of mucin (glycoprotein), lipids, inorganic salts, cell fragments, immunoglobulins, etc. Adhesion On the inner side of the intestinal wall, the intestinal epithelial cells are continuously secreted and renewed into the intestinal lumen, which play a role in lubricating and preventing the invasion of exogenous harmful substances (toxins, bacteria, viruses, etc.)

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