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Biodegradable composite type tubular urethral stent and preparation method

A composite, tubular technology, used in the medical field, can solve the problems of easy complications, trauma, and limited material extraction at the site of the material, achieve good biocompatibility and mechanical properties, promote growth, and avoid complications. Effect

Inactive Publication Date: 2015-04-01
金华市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a degradable composite tubular urethral stent and a degradable composite tubular urethral stent for the existing long-section urethral stricture treatment method, which has the disadvantages of wounding when taking materials, limited amount of materials taken, and complications easily caused by taking materials. Preparation

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  • Biodegradable composite type tubular urethral stent and preparation method
  • Biodegradable composite type tubular urethral stent and preparation method
  • Biodegradable composite type tubular urethral stent and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A preparation method of a degradable composite tubular urethral stent, the preparation method comprising the following steps:

[0031] (1) The polymer material polylactic acid PLA and polyglycolic acid PGA are mixed in a molar ratio of 50:50, and the polylactic acid-glycolic acid copolymer PLGA nanoscale electrospun fiber membrane is prepared by electrospinning technology. The surface of the electrospun fiber membrane was modified by grafting type I collagen to obtain the modified polylactic acid-glycolic acid copolymer PLGA film;

[0032] (2) Soak the small intestinal submucosa cell tissue in the decellularization solution made by mixing polyethylene glycol octylphenyl ether-100 (Triton X-100) with a volume concentration of 0.2% and ammonia water with a volume concentration of 0.03% In the above method, shake and decellularize, then freeze at -40°C and dry in vacuum to obtain the small intestine decellularized matrix SIS film;

[0033] (3) According to the diameter re...

Embodiment 2

[0037] A preparation method of a degradable composite tubular urethral stent, the preparation method comprising the following steps:

[0038] (1) The polymer materials polylactic acid PLA and polyglycolic acid PGA are mixed in a molar ratio of 75:25, and electrospinning technology is used to prepare polylactic acid-glycolic acid copolymer PLGA nanoscale electrospun fiber membrane with a thickness of 0.4 mm, the porosity is 90%, the electrospinning diameter is 300-450nm, and the pore diameter is 60-100μm; the surface of the prepared electrospun fiber membrane is modified by grafting type I collagen to obtain the modified polylactic acid- Glycolic acid copolymer PLGA film;

[0039] (2) Soak the small intestinal submucosa cell tissue in the decellularization solution made by mixing polyethylene glycol octylphenyl ether-100 (Triton X-100) with a volume concentration of 0.2% and ammonia water with a volume concentration of 0.03% In the method, shake and decellularize, then freeze at...

Embodiment 3

[0043] A preparation method of a degradable composite tubular urethral stent, the preparation method comprising the following steps:

[0044] (1) The polymer material polylactic acid PLA and polyglycolic acid PGA are mixed in a molar ratio of 85:15, and the polylactic acid-glycolic acid copolymer PLGA nanoscale electrospun fiber membrane is prepared by electrospinning technology. The surface of the electrospun fiber membrane was modified by grafting type I collagen to obtain the modified polylactic acid-glycolic acid copolymer PLGA film;

[0045] (2) Soak the small intestinal submucosa cell tissue in the decellularization solution made by mixing polyethylene glycol octylphenyl ether-100 (Triton X-100) with a volume concentration of 0.2% and ammonia water with a volume concentration of 0.03% In the above method, shake and decellularize, then freeze at -50°C and dry in vacuum to obtain the small intestine decellularized matrix SIS film;

[0046] (3) According to the diameter re...

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Abstract

The invention provides a biodegradable composite type tubular urethral stent and a preparation method. By the biodegradable composite type tubular urethral stent and the preparation method, the shortcomings that the using quantity of the existing patch materials is limited and complications are easily caused on sampled portions are overcome. The biodegradable tissue engineering stent comprises an inner layer and an outer layer, wherein the inner layer is tubular; the outer layer is arranged on the outer surface of the inner layer; the inner layer and the outer layer are made of degradable high polymer materials and acellular stromata; the degradable high polymer materials are polylactic acid- polylactic-co-glycolic acid (PLGA) films; the acellular stromata are small intestinal submucosa (SIS) films; and the polylactic acid- polylactic-co-glycolic acid (PLGA) films and the small intestinal submucosa (SIS) films are connected to one another. By the biodegradable composite type tubular urethral stent, autologous sampling is not required during urethral canal compounding and reestablishment, and the complications which are possibly caused on the sampled portions are avoided.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a degradable composite tubular urethral stent and a preparation method thereof. Background technique [0002] Urethral stricture caused by various factors such as traumatic or iatrogenic urethral injury, gonococcal or non-specific urethritis, and congenital urethral lesions is one of the difficulties faced by urologists. Conventional treatment methods include urethral dilatation, internal urethral incision, and end-to-end urethral anastomosis, which are only suitable for patients with short-distance urethral strictures. For patients with long-segment urethral strictures, alternative surgery is mainly used. Membrane, oral mucosa, and lingual mucosa are all used as patch materials in urethral repair surgery; however, the sampling usually causes complications at the sampling site, and the amount of sampling is limited. Contents of the invention [0003] The purpose of the presen...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L31/04A61L31/10A61L31/14
Inventor 杜小文
Owner 金华市人民医院
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